Utrophin up-regulation by an artificial transcription factor in transgenic mice.

Autor: Elisabetta Mattei, Nicoletta Corbi, Maria Grazia Di Certo, Georgios Strimpakos, Cinzia Severini, Annalisa Onori, Agata Desantis, Valentina Libri, Serena Buontempo, Aristide Floridi, Maurizio Fanciulli, Dilair Baban, Kay E Davies, Claudio Passananti

Publikováno v: PLoS ONE, Vol 2, Iss 8, p e774 (2007)

Duchenne Muscular Dystrophy (DMD) is a severe muscle degenerative disease, due to absence of dystrophin. There is currently no effective treatment for DMD. Our aim is to up-regulate the expression level of the dystrophin related gene utrophin in DMD,

Externí odkaz: https://doaj.org/article/048d05e732e0409cba8e9153bd4c3701

Che-1/AATF-induced transcriptionally active chromatin promotes cell proliferation in multiple myeloma

Autor: Enrico P. Spugnini, Katja Höpker, Mario Cioce, Luca Baldini, Bruno Amadio, Giacomo Corleone, Svitlana Gumenyuk, Giancarlo Cortese, Giovanni Blandino, Giovanni Cigliana, Simona Iezzi, Francesca De Nicola, Maurizio Fanciulli, Matteo Pallocca, Aristide Floridi, Francesco Pisani, Cristina Sorino, Maria Rosaria Ricciardi, Frauke Goeman, Tiziana Bruno, Bruno Vincenzi, Andrea Mengarelli, Elisabetta Mattei, Maria Teresa Petrucci, Umberto Gianelli, Thomas Benzing, Valeria Catena, Alfonso Baldi, Roberta Merola, Claudio Passananti, Gianluca Bossi

Publikováno v: Blood Adv
Blood advances 4 (2020): 5616–5630. doi:10.1182/bloodadvances.2020002566
info:cnr-pdr/source/autori:Tiziana Bruno 1, Francesca De Nicola 1, Giacomo Corleone 1, Valeria Catena 1, Frauke Goeman 1, Matteo Pallocca 1, Cristina Sorino 1, Gianluca Bossi 2, Bruno Amadio 1, Giovanni Cigliana 3, Maria Rosaria Ricciardi 4, Maria Teresa Petrucci 5, Enrico Pierluigi Spugnini 1, Alfonso Baldi 6, Mario Cioce 2, Giancarlo Cortese 1, Elisabetta Mattei 7, Roberta Merola 3, Umberto Gianelli 8, Luca Baldini 8, Francesco Pisani 9, Svitlana Gumenyuk 9, Andrea Mengarelli 9, Katja Höpker 10, Thomas Benzing 10 11 12, Bruno Vincenzi 13, Aristide Floridi 1, Claudio Passananti 14, Giovanni Blandino 2, Simona Iezzi 1, Maurizio Fanciulli 1/titolo:Che-1%2FAATF-induced transcriptionally active chromatin promotes cell proliferation in multiple myeloma/doi:10.1182%2Fbloodadvances.2020002566/rivista:Blood advances/anno:2020/pagina_da:5616/pagina_a:5630/intervallo_pagine:5616–5630/volume:4

Multiple myeloma (MM) is a hematologic malignancy produced by a clonal expansion of plasma cells and characterized by abnormal production and secretion of monoclonal antibodies. This pathology exhibits an enormous heterogeneity resulting not only fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc1af284419cc671558000110b541c9b
http://hdl.handle.net/11591/438908

Che‐1‐induced inhibition of mTOR pathway enables stress‐induced autophagy

Autor: Marta Chesi, Francesca La Rosa, Francesca De Nicola, P. Leif Bergsagel, Giovanni Tonon, Aristide Floridi, Elena Lesma, Tiziana Bruno, Frauke Goeman, Claudio Passananti, Gianluca Bossi, Vincenzo Federico, Maurizio Fanciulli, Valeria Catena, Maria Teresa Petrucci, Maria Rosaria Ricciardi, Cristina Sorino, Tiziana Castrignanò, Paolo D'Onorio De Meo, Maurilio Ponzoni, Giovanni Blandino, Francesco Pisani, Simona Iezzi, Agata Desantis

Publikováno v: The EMBO Journal. 34:1214-1230

Mammalian target of rapamycin (mTOR) is a key protein kinase that regulates cell growth, metabolism, and autophagy to maintain cellular homeostasis. Its activity is inhibited by adverse conditions, including nutrient limitation, hypoxia, and DNA dama

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edd4d37294285c8769301c4d7c0646ac
https://doi.org/10.15252/embj.201489920

Che-1 Promotes Tumor Cell Survival by Sustaining Mutant p53 Transcription and Inhibiting DNA Damage Response Activation

Autor: Claudio Passananti, Agata Desantis, Simona Iezzi, Francesca La Rosa, Maurizio Fanciulli, Alfonso Bellacosa, Gianluca Bossi, Giovanni Blandino, Aristide Floridi, Annapaola Franchitto, Silvia Di Agostino, Sergio Galanti, Barbara Benassi, Cristina Sorino, Francesca De Nicola, Tiziana Bruno

Publikováno v: Cancer cell
18 (2010): 122–134. doi:10.1016/j.ccr.2010.05.027
info:cnr-pdr/source/autori:Bruno T; Desantis A; Bossi G; Di Agostino S; Sorino C; De Nicola F; Iezzi S; Franchitto A; Benassi B; Galanti S; La Rosa F; Floridi A; Bellacosa A; Passananti C; Blandino G; Fanciulli M./titolo:Che-1 promotes tumor cell survival by sustaining mutant p53 transcription and inhibiting DNA damage response activation/doi:10.1016%2Fj.ccr.2010.05.027/rivista:Cancer cell (Print)/anno:2010/pagina_da:122/pagina_a:134/intervallo_pagine:122–134/volume:18

Summary Che-1 is a RNA polymerase II binding protein involved in the regulation of gene transcription and, in response to DNA damage, promotes p53 transcription. In this study, we investigated whether Che-1 regulates mutant p53 expression. We found t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c3c334657b429e8ffb398d04110ed57

Che-1 enhances cyclin-dependent kinase 5 expression and interacts with the active kinase-complex

Autor: Claudio Passananti, Maria Teresa Ciotti, Aristide Floridi, Maurizio Fanciulli, Nicoletta Corbi, Christian Barbato, Tiziana Bruno, Serena Buontempo

Publikováno v: NeuroReport. 19:531-535

Che-1 is a nuclear protein involved in the regulation of gene transcription and cell proliferation. It has also been shown to localize to the cytoplasm of postmitotic neuronal cells, where it is able to interact with the microtubule-associated protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e19a50dbc98c55fd497d07bd2713df
https://doi.org/10.1097/wnr.0b013e3282f85c1b