Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Arisa Masuda"'
Autor:
Yukiko Yamashita, Keigo Gohda, Yusuke Iguchi, Ko Fujimori, Keisuke Oda, Arisa Masuda, Mizuho Une, Naoki Teno
Publikováno v:
Bioorganic & Medicinal Chemistry. 85:117238
Publikováno v:
Journal of Society of Cosmetic Chemists of Japan. 54:358-363
Autor:
Takie Hiramoto, Tomoko Nishimaki-Mogami, Ko Fujimori, Yukiko Yamashita, Yusuke Iguchi, Keigo Gohda, Keisuke Oda, Arisa Masuda, Mizuho Une, Naoki Teno
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:2220-2227
Antagonizing transcriptional activity of farnesoid X receptor (FXR) in the intestine has been reported as an effective means for the treatment of nonalcoholic fatty liver disease, type 2 diabetes and obesity. We describe herein that the building bloc
Autor:
Arisa Masuda, Keigo Gohda, Naoki Teno, Yusuke Iguchi, Yukiko Yamashita, Keisuke Oda, Ko Fujimori, Mizuho Une
Publikováno v:
ACS Med Chem Lett
[Image: see text] We describe the discovery of analog 15 (FLG249), which is an orally active and nonsteroidal farnesoid X receptor (FXR) antagonist in mice with unique profiles, such as a propensity for ileum distribution and the significant control
Publikováno v:
Bioorganicmedicinal chemistry letters. 41
Farnesoid X receptor (FXR) controls gene-expression relevant to various diseases including nonalcoholic steatohepatitis and has become a drug target to regulate metabolic aberrations. However, some side effects of FXR agonists reported in clinical de
Autor:
Arisa, Masuda, Keigo, Gohda, Yusuke, Iguchi, Ko, Fujimori, Yukiko, Yamashita, Keisuke, Oda, Mizuho, Une, Naoki, Teno
Publikováno v:
Bioorganicmedicinal chemistry. 28(14)
As a cellular bile acid sensor, farnesoid X receptor (FXR) participates in regulation of bile acid, lipid and glucose homeostasis, and liver protection. With respect to the bone metabolism, FXR positively regulates bone metabolism through both bone f
Autor:
Naoki Teno, Yukiko Yamashita, Mizuho Une, Keigo Gohda, Yusuke Iguchi, Keisuke Oda, Arisa Masuda, Ko Fujimori
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115512
As a cellular bile acid sensor, farnesoid X receptor (FXR) participates in regulation of bile acid, lipid and glucose homeostasis, and liver protection. With respect to the bone metabolism, FXR positively regulates bone metabolism through both bone f
Autor:
Arisa Masuda, Reiri Kobayashi, Hiroyuki Onuki, Saeka Kurebayashi, Ayako Washio, Ryo Takeuchi, Kanako Tazawa, Chiaki Kuroda
Publikováno v:
Natural Product Communications. 15:1934578X2090141
As a possible route to phenylalanine, reaction of aminomalononitrile with benzylic compounds was studied. 2-Benzyl-2-aminomalononitrile (3) was obtained in a good yield when aminomalononitrile p-toluenesulfonate (1) was treated with benzyl bromide (2
Autor:
Arisa Masuda, Mitsuhito Araki, Eriko Akiduki, Tadamune Otsubo, Maiko Akagawa, Naoki Teno, Keiko Wanaka, Yukiko Yamashita, Keigo Gohda, Yuko Tsuda
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:3696-3704
Here we report a series of plasmin inhibitors which were originally derived from the parent structure of 1 and 2. Our efforts focused on the optimization of the P4 moiety of 2 and on the quest of alternative scaffold to pyrrolopyrimidine in the paren
Autor:
Yasuhito Tanaka, Hirokazu Komatsu, Arisa Masuda, Asahi Ito, Takashi Yoshida, Haruhito Totani, Shigeru Kusumoto, Hiroshi Inagaki, Shuko Murakami, Ryuzo Ueda, Masaki Ri, Akio Niimi, Shinsuke Iida, Masashi Mizokami, Takashi Ishida
Publikováno v:
International Journal of Hematology. 101:398-404
Reactivation of hepatitis B virus (HBV) infection may occur in adult T-cell leukemia-lymphoma (ATL) patients with resolved HBV infection who receive monotherapy with the anti-CC chemokine receptor 4 monoclonal antibody, mogamulizumab. However, there