An infrared spectral biomarker accurately predicts neurodegenerative disease class in the absence of overt symptoms

Autor: Aris Polyzos, Dhruba Ghosh, Lila Lovergne, Renaud Schuck, Edward S. Barnard, James B. Brown, Michael C. Martin, Andrew D. Chen, Cynthia T. McMurray

Publikováno v: Scientific reports, vol 11, iss 1
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)

Although some neurodegenerative diseases can be identified by behavioral characteristics relatively late in disease progression, we currently lack methods to predict who has developed disease before the onset of symptoms, when onset will occur, or th

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https://escholarship.org/uc/item/58m3f68f

The chicken or the egg: mitochondrial dysfunction as a cause or consequence of toxicity in Huntington’s disease

Autor: Aris Polyzos, Cynthia T. McMurray

Publikováno v: Mechanisms of ageing and development, vol 161, iss Pt A
Polyzos, AA; & McMurray, CT. (2017). The chicken or the egg: mitochondrial dysfunction as a cause or consequence of toxicity in Huntington's disease. Mechanisms of Ageing and Development, 161, 181-197. doi: 10.1016/j.mad.2016.09.003. Lawrence Berkeley National Laboratory: Lawrence Berkeley National Laboratory. Retrieved from: http://www.escholarship.org/uc/item/6m92f4qs

© 2016 Mitochondrial dysfunction and ensuing oxidative damage is typically thought to be a primary cause of Huntington's disease, Alzheimer's disease, and Parkinson disease. There is little doubt that mitochondria (MT) become defective as neurons di

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https://doi.org/10.1016/j.mad.2016.09.003

Combination of weekly topotecan and gemcitabine as a salvage treatment in patients with recurrent ovarian cancer: a phase I study

Autor: Kostas Kalbakis, Dora Hatzidaki, Vassilis Georgoulias, Nikolaos Vardakis, Aris Polyzos, Nikolaos Kentepozidis, Athanasios Kotsakis, John Syrios, Charalambos Kouroussis, Emmanouil Kontopodis

Publikováno v: Minerva ginecologica. 71(3)

Background Evaluation of safety of the weekly intravenous gemcitabine/topotecan combination as salvage treatment in patients with recurrent epithelial ovarian cancer. Methods Twenty-four women with histologically-proven relapsed ovarian cancer (ROC)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e67dcddfcf87a424099cc6c438df32
https://pubmed.ncbi.nlm.nih.gov/30727721

Salvage treatment with irinotecan/cisplatin versus pemetrexed/cisplatin in patients with non-small cell lung cancer pre-treated with a non-platinum-based regimen in the first-line setting: a randomized phase II study of the Hellenic Oncology Research Group (HORG)

Autor: P. Economopoulou, Athanasios Kotsakis, Kostas Kalbakis, Leonidas Chelis, Lambros Vamvakas, N. Vardakis, F. Koinis, Ch. Nikolaou, Aris Polyzos, V. Georgoulias, Nikolaos Kentepozidis, P. Katsaounis, Ch. Christofyllakis

Publikováno v: Clinical and Translational Oncology. 19:317-325

Platinum-based chemotherapy is the standard front-line treatment for patients with advanced non-small cell lung cancer (NSCLC). However, non-platinum combinations of third-generation chemotherapeutic agents are considered an alternative therapeutic o

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https://doi.org/10.1007/s12094-016-1532-y

XJB-5-131-mediated improvement in physiology and behaviour of the R6/2 mouse model of Huntington's disease is age- and sex- dependent

Autor: Peter Wipf, Nigel I. Wood, Paul T. Williams, Aris Polyzos, Cynthia T. McMurray, A. Jennifer Morton

Publikováno v: PLoS ONE, Vol 13, Iss 4, p e0194580 (2018)
PloS one, vol 13, iss 4
PLoS ONE
Polyzos, AA; Wood, NI; Williams, P; Wipf, P; Jennifer Morton, A; & McMurray, CT. (2018). XJB-5-131-mediated improvement in physiology and behaviour of the R6/2 mouse model of Huntington’s disease is age-and sex-dependent. PLoS ONE, 13(4), e0194580. doi: 10.1371/journal.pone.0194580. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/8v41b9kn

This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49a63cfc8be5f89b1f248b6f0381ff17
http://europepmc.org/articles/PMC5890981?pdf=render