Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Ariosto S Silva"'
Autor:
Marwa Tantawy, Guang Yang, Raghunandan Reddy Algubelli, Gabriel DeAvila, Samuel M. Rubinstein, Robert F. Cornell, Michael G. Fradley, Erin M. Siegel, Oliver A. Hampton, Ariosto S. Silva, Daniel Lenihan, Kenneth H. Shain, Rachid C. Baz, Yan Gong
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
BackgroundProteasome inhibitor Carfilzomib (CFZ) is effective in treating patients with refractory or relapsed multiple myeloma (MM) but has been associated with cardiovascular adverse events (CVAE) such as hypertension, cardiomyopathy, and heart fai
Externí odkaz:
https://doaj.org/article/d2f22b870497486d9a0014b93469fa85
Autor:
AGM Mostofa, Allison Distler, Mark B. Meads, Eva Sahakian, John J. Powers, Alexandra Achille, David Noyes, Gabriela Wright, Bin Fang, Victoria Izumi, John Koomen, Rupal Rampakrishnan, Tuan P. Nguyen, Gabriel De Avila, Ariosto S. Silva, Praneeth Sudalagunta, Rafael Renatino Canevarolo, Maria D. Coelho Siqueira Silva, Raghunandan Reddy Alugubelli, Hongyue A. Dai, Amit Kulkarni, William S. Dalton, Oliver A. Hampton, Eric A. Welsh, Jamie K. Teer, Alexandre Tungesvik, Kenneth L. Wright, Javier Pinilla-Ibarz, Eduardo M. Sotomayor, Kenneth H. Shain, Jason Brayer
Publikováno v:
JCI Insight, Vol 6, Iss 24 (2021)
The clinical utility of histone/protein deacetylase (HDAC) inhibitors in combinatorial regimens with proteasome inhibitors for patients with relapsed and refractory multiple myeloma (MM) is often limited by excessive toxicity due to HDAC inhibitor pr
Externí odkaz:
https://doaj.org/article/7fe4645c54d74f3db9e69957840e8738
Autor:
Benjamin B. Morris, Jason P. Smith, Qi Zhang, Zhijie Jiang, Oliver A. Hampton, Michelle L. Churchman, Susanne M. Arnold, Dwight H. Owen, Jhanelle E. Gray, Patrick M. Dillon, Hatem H. Soliman, Daniel G. Stover, Howard Colman, Arnab Chakravarti, Kenneth H. Shain, Ariosto S. Silva, John L. Villano, Michael A. Vogelbaum, Virginia F. Borges, Wallace L. Akerley, Ryan D. Gentzler, Richard D. Hall, Cindy B. Matsen, C. M. Ulrich, Andrew R. Post, David A. Nix, Eric A. Singer, James M. Larner, Peter Todd Stukenberg, David R. Jones, Marty W. Mayo
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1570 (2022)
In the past decade, defective DNA repair has been increasingly linked with cancer progression. Human tumors with markers of defective DNA repair and increased replication stress exhibit genomic instability and poor survival rates across tumor types.
Externí odkaz:
https://doaj.org/article/df3f2dd332a741889c5d48abf7420c89
Autor:
Praneeth Sudalagunta, Maria C. Silva, Rafael R. Canevarolo, Raghunandan Reddy Alugubelli, Gabriel DeAvila, Alexandre Tungesvik, Lia Perez, Robert Gatenby, Robert Gillies, Rachid Baz, Mark B. Meads, Kenneth H. Shain, Ariosto S. Silva
Publikováno v:
EBioMedicine, Vol 54, Iss , Pp - (2020)
Background: Multiagent therapies, due to their ability to delay or overcome resistance, are a hallmark of treatment in multiple myeloma (MM). The growing number of therapeutic options in MM requires high-throughput combination screening tools to bett
Externí odkaz:
https://doaj.org/article/2bfb0dce927d404ba1fd3ed314b63a77
Autor:
Robert A. Gatenby, Robert J. Gillies, Susan E. Minton, Zayar P. Khin, Yoonseok Kam, Ariosto S. Silva
PDF file - 41K, Computational model of competition between drug sensitive and PGP+ mutants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f9ef7046e93642e954ecb136312261
https://doi.org/10.1158/0008-5472.22394054.v1
https://doi.org/10.1158/0008-5472.22394054.v1
Autor:
Ariosto S. Silva, Kenneth Shain, Rachid Baz, Lia Perez, Lori Hazlehurst, Timothy Jacobson, Maria L.C. Ribeiro, Zayar P. Khin
PDF file - 29K, Computational modeling of clinical response to therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931c1be1391c869c1293441d006b04eb
https://doi.org/10.1158/0008-5472.22399437
https://doi.org/10.1158/0008-5472.22399437
Autor:
Ariosto S. Silva, Kenneth Shain, Rachid Baz, Lia Perez, Lori Hazlehurst, Timothy Jacobson, Maria L.C. Ribeiro, Zayar P. Khin
PDF file - 126K, The duration of melphalan toxicity post-withdrawal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c57fd6fc58cf99e4e65ae3dd9c76227
https://doi.org/10.1158/0008-5472.22399449
https://doi.org/10.1158/0008-5472.22399449
Autor:
Ariosto S. Silva, Kenneth Shain, Rachid Baz, Lia Perez, Lori Hazlehurst, Timothy Jacobson, Maria L.C. Ribeiro, Zayar P. Khin
PDF file - 66K, Loss of membrane motion is an early event in cell death, preceding loss of membrane integrity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146e2f6017b32dcc9aa71f57ada465f2
https://doi.org/10.1158/0008-5472.22399455
https://doi.org/10.1158/0008-5472.22399455
Autor:
Ariosto S. Silva, Kenneth Shain, Rachid Baz, Lia Perez, Lori Hazlehurst, Timothy Jacobson, Maria L.C. Ribeiro, Zayar P. Khin
PDF file - 40K, Computational modeling of in vivo response to therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa50c529e981d0bb7bd3a53415b636e
https://doi.org/10.1158/0008-5472.22399440.v1
https://doi.org/10.1158/0008-5472.22399440.v1
Autor:
Ariosto S. Silva, Kenneth Shain, Rachid Baz, Lia Perez, Lori Hazlehurst, Timothy Jacobson, Maria L.C. Ribeiro, Zayar P. Khin
PDF file - 174K, Description of the processing of bone marrow aspirates, as well as the source code for fitting of cell viability measurements into dose/response surfaces.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c6f5131880f6edd7926211440c1886d
https://doi.org/10.1158/0008-5472.22399431.v1
https://doi.org/10.1158/0008-5472.22399431.v1