Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment.

Autor: Denis Evseenko, Brooke Latour, Wade Richardson, Mirko Corselli, Arineh Sahaghian, Sofie Cardinal, Yuhua Zhu, Rebecca Chan, Bruce Dunn, Gay M Crooks

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e63718 (2013)

Lysophosphatidic acid (LPA) is a pleiotropic phospholipid present in the blood and certain tissues at high concentrations; its diverse effects are mediated through differential, tissue specific expression of LPA receptors. Our goal was to determine i

Externí odkaz: https://doaj.org/article/2ef8d37459c2416897af51fa8c08f089

Modification of Hematopoietic Stem/Progenitor Cells with CD19-Specific Chimeric Antigen Receptors as a Novel Approach for Cancer Immunotherapy

Autor: Jennifer Wherley, Andy Tu, Irena Tremcinska, Donald B. Kohn, Satiro N. De Oliveira, Christine Ryan, David Elashoff, Cinnamon L Hardee, Laurence J.N. Cooper, Francesca Giannoni, Roger P. Hollis, Arineh Sahaghian, Tristan Grogan, Behrod Katebian

Publikováno v: De Oliveira, Satiro N; Ryan, Christine; Giannoni, Francesca; Hardee, Cinnamon L; Tremcinska, Irena; Katebian, Behrod; et al.(2013). Modification of hematopoietic stem/progenitor cells with CD19-specific chimeric antigen receptors as a novel approach for cancer immunotherapy.. Human gene therapy, 24(10), 824-839. UCLA: Retrieved from: http://www.escholarship.org/uc/item/7rj3w050

Chimeric antigen receptors (CARs) against CD19 have been shown to direct T-cells to specifically target B-lineage malignant cells in animal models and clinical trials, with efficient tumor cell lysis. However, in some cases, there has been insufficie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d50c7b9bda7a57f3377d29c367946bf
https://doi.org/10.1089/hum.2012.202

Low- and High-Temperature Tolerance and Acclimation for Chlorenchyma versus Meristem of the Cultivated Cacti Nopalea cochenillifera, Opuntia robusta, and Selenicereus megalanthus

Autor: Brian R. Zutta, Alenoush M. Aramians, Park S. Nobel, Arineh Sahaghian

Publikováno v: Journal of Botany, Vol 2011 (2011)

Dividing meristematic cells are thought to be more sensitive to extreme temperatures compared to other tissues, such as chlorenchyma. This was examined for low and high temperatures for three widely cultivated cacti: Nopalea cochenillifera, Opuntia r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15632a34bec4225581a3c2d09459e25d
https://doi.org/10.1155/2011/347168

Novel pathways to erythropoiesis induced by dimerization of intracellular C-Mpl in human hematopoietic progenitors

Autor: Chintan Parekh, Arineh Sahaghian, William Kim, Jessica Scholes, Shundi Ge, Yuhua Zhu, Shahab Asgharzadeh, Roger Hollis, Donald Kohn, Lingyun Ji, Jemily Malvar, Xiaoyan Wang, Gay Crooks

Publikováno v: Stem cells (Dayton, Ohio). 30(4)

The cytokine thrombopoietin (Tpo) plays a critical role in hematopoiesis by binding to the extracellular domain and inducing homodimerization of the intracellular signaling domain of its receptor, c-Mpl. Mpl homodimerization can also be accomplished

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd1e1dbf6de6eaccb0895cb3a45cd311
https://pubmed.ncbi.nlm.nih.gov/22290824