Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Arik Shams"'
Autor:
Arik Shams, Sean A. Higgins, Christof Fellmann, Thomas G. Laughlin, Benjamin L. Oakes, Rachel Lew, Shin Kim, Maria Lukarska, Madeline Arnold, Brett T. Staahl, Jennifer A. Doudna, David F. Savage
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Proteins evolve through the modular rearrangement of domains. Here the authors introduce MISER, a minimization by iterative size-exclusion and recombination method to make all possible deletions of a protein, uncovering functions for Cas9 domains inv
Externí odkaz:
https://doaj.org/article/f92b1a4bf0574fe9b95344d8bcec8e40
Autor:
Douglas Iverson, Crystal Serrano, Ann Marie Brahan, Arik Shams, Filbert Totsingan, Anthony J. Bell Jr.
Publikováno v:
Data in Brief, Vol 5, Iss C, Pp 756-760 (2015)
Holliday or DNA four-way junctions (4WJs) are cruciform/bent structures composed of four DNA duplexes. 4WJs are key intermediates in homologous genetic recombination and double-strand break repair. To investigate 4WJs in vitro, junctions are assemble
Externí odkaz:
https://doaj.org/article/90716fb6328d496cb18880bfc3876061
Autor:
Rachel J. Lew, Christof Fellmann, Thomas G. Laughlin, Arik Shams, Benjamin L. Oakes, Maria Lukarska, David F. Savage, Jennifer A. Doudna, Brett T. Staahl, Shin Kim, Sean Higgins, Madeline L. Arnold
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications
Proteins evolve through the modular rearrangement of elements known as domains. Extant, multidomain proteins are hypothesized to be the result of domain accretion, but there has been limited experimental validation of this idea. Here, we introduce a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f70d441a833ddfbd416ccca873bb39
https://doaj.org/article/f92b1a4bf0574fe9b95344d8bcec8e40
https://doaj.org/article/f92b1a4bf0574fe9b95344d8bcec8e40
Autor:
Rui Gong, Fangfang Jiang, Zane G. Moreland, Matthew J. Reynolds, Santiago Espinosa de los Reyes, Pinar Gurel, Arik Shams, James B. Heidings, Michael R. Bowl, Jonathan E. Bird, Gregory M. Alushin
Publikováno v:
Science Advances. 8
The motor protein myosin-15 is necessary for the development and maintenance of mechanosensory stereocilia, and mutations in myosin-15 cause hereditary deafness. In addition to transporting actin regulatory machinery to stereocilia tips, myosin-15 di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9fa7c4baecd9aa108636e5125e7b0ec
https://doi.org/10.1126/sciadv.abl4733
https://doi.org/10.1126/sciadv.abl4733
Autor:
Yasuharu Takagi, Michael R. Bowl, James R. Sellers, Jesse C. Werth, Elizabeth A. Wilson, Arik Shams, Zane G. Moreland, Andrew Parker, Randall Harley, Stacey M. Cole, Steve D.M. Brown, Gregory M. Alushin, Fangfang Jiang, Susan Morse, Jonathan E. Bird, Melanie Barzik, Carlos A. Aguilar, Rui Gong, Daniel C. Sutton, Christian C. Faaborg-Andersen, Thomas B. Friedman
SUMMARYThe assembly and maintenance of actin-based mechanosensitive stereocilia in the cochlea is critical for lifelong hearing. Myosin-15 (MYO15) is hypothesized to modulate stereocilia height by trafficking actin regulatory proteins to their tip co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::633ca048bbe52ea2dce53eef8777a33e
https://doi.org/10.1101/2021.07.09.451618
https://doi.org/10.1101/2021.07.09.451618
Autor:
Michael R. Bowl, Arik Shams, Zane G. Moreland, Matthew J. Reynolds, Santiago Reyes, Gregory M. Alushin, Fangfang Jiang, Jonathan E. Bird, Rui Gong, Pinar S. Gurel
SummaryThe motor protein myosin-15 is necessary for the development and maintenance of mechanosensory stereocilia, and myosin-15 mutations cause profound deafness. In a companion study, we report that myosin-15 nucleates actin filament (“F-actin”
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44f42218725ff63a7bec8fd7ab787a2a
https://doi.org/10.1101/2021.07.09.451843
https://doi.org/10.1101/2021.07.09.451843
Autor:
David F. Savage, Benjamin L. Oakes, Rachel J. Lew, Christof Fellmann, Madeline L. Arnold, Maria Lukarska, Brett T. Staahl, Sean Higgins, Jennifer A. Doudna, Arik Shams, Thomas J. Laughlin
Proteins evolve through the modular rearrangement of elements known as domains. It is hypothesized that extant, multidomain proteins are the result of domain accretion, but there has been limited experimental validation of this idea. Here, we introdu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1f66e6e83764defec213e57cff04e32
https://doi.org/10.1101/2020.10.19.344077
https://doi.org/10.1101/2020.10.19.344077
Autor:
Thomas B. Friedman, Jonathan E. Bird, Yasuharu Takagi, James R. Sellers, Fangfang Jiang, Arik Shams, Sarah M. Heissler
Publikováno v:
The Journal of Biological Chemistry
Cochlear hair cells possess an exquisite bundle of actin-based stereocilia that detect sound. Unconventional myosin 15 (MYO15A) traffics and delivers critical molecules required for stereocilia development and is essential for building the mechanosen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35d1a6e721765d20613c14dc5a6fc2ea
https://doi.org/10.1074/jbc.ra120.014903
https://doi.org/10.1074/jbc.ra120.014903
Autor:
Filbert Totsingan, Crystal Serrano, Ann Marie Brahan, Douglas Iverson, Anthony J. Bell, Arik Shams
Publikováno v:
Archives of Biochemistry and Biophysics. 587:1-11
The objective of this study is to evaluate the structure and protein recognition properties of hybrid four-way junctions (4WJs) composed of DNA and peptide nucleic acid (PNA) strands. We compare a classic immobile DNA junction, J1, vs. six PNA-DNA ju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc4737c600194e7dc522a57fbd149740
https://doi.org/10.1016/j.abb.2015.08.017
https://doi.org/10.1016/j.abb.2015.08.017
Autor:
Anthony J. Bell, Ann Marie Brahan, Douglas Iverson, Crystal Serrano, Filbert Totsingan, Arik Shams
Publikováno v:
Data in Brief
Data in Brief, Vol 5, Iss C, Pp 756-760 (2015)
Data in Brief, Vol 5, Iss C, Pp 756-760 (2015)
Holliday or DNA four-way junctions (4WJs) are cruciform/bent structures composed of four DNA duplexes. 4WJs are key intermediates in homologous genetic recombination and double-strand break repair. To investigate 4WJs in vitro, junctions are assemble
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90799c813a0b9c5285733b6cfd91f467
http://europepmc.org/articles/PMC4659781
http://europepmc.org/articles/PMC4659781