Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Arik J Hone"'
Autor:
Alicia Hernández-Vivanco, Arik J Hone, Mick L Scadden, Beatriz Carmona-Hidalgo, J Michael McIntosh, Almudena Albillos
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94142 (2014)
Nicotinic acetylcholine receptors (nAChRs) that contain α6 and β4 subunits have been demonstrated functionally in human adrenal chromaffin cells, rat dorsal root ganglion neurons, and on noradrenergic terminals in the hippocampus of adolescent mice
Externí odkaz:
https://doaj.org/article/382a78ac57c8414f9c6b09511bb074ad
Autor:
Jorge L. B. Neves, Cristoval Urcino, Kevin Chase, Cheryl Dowell, Arik J. Hone, David Morgenstern, Victor M. Chua, Iris Bea L. Ramiro, Julita S. Imperial, Lee S. Leavitt, Jasmine Phan, Fernando A. Fisher, Maren Watkins, Shrinivasan Raghuraman, Jortan O. Tun, Beatrix M. Ueberheide, J. Michael McIntosh, Vitor Vasconcelos, Baldomero M. Olivera, Joanna Gajewiak
Publikováno v:
Marine Drugs, Vol 22, Iss 3, p 118 (2024)
The venom of cone snails has been proven to be a rich source of bioactive peptides that target a variety of ion channels and receptors. α-Conotoxins (αCtx) interact with nicotinic acetylcholine receptors (nAChRs) and are powerful tools for investig
Externí odkaz:
https://doaj.org/article/eb10793f322b4e929d26fb3a31f6499e
Autor:
Arik J. Hone, J. Michael McIntosh
Publikováno v:
Pharmacological Research, Vol 190, Iss , Pp 106715- (2023)
Nicotinic acetylcholine receptors (nAChRs) have been historically defined as ligand-gated ion channels and function as such in the central and peripheral nervous systems. Recently, however, non-ionic signaling mechanisms via nAChRs have been demonstr
Externí odkaz:
https://doaj.org/article/e3dca2c0dcc244888c3c7ab7f37cf7d2
Autor:
Arik J. Hone, J. Michael McIntosh
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
In the nervous system, nicotinic acetylcholine receptors (nAChRs) rapidly transduce a chemical signal into one that is electrical via ligand-gated ion flux through the central channel of the receptor. However, some nAChR subunits are expressed by non
Externí odkaz:
https://doaj.org/article/13e4de7b005b4f66b4ce7b2e24b69f0e
Autor:
Arik J. Hone, Quentin Kaas, J. Michael McIntosh, Ireland Kearns, Joanna Gajewiak, Fuaad Hararah, Sean Christensen, David J. Craik
Publikováno v:
J Med Chem
Nicotinic acetylcholine receptors (nAChRs) are pharmacological targets for the treatment of neuropathic pain, and the α6β4 subtype has been identified as particularly promising. Rat α6β4 nAChRs are less sensitive to some ligands than the human ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bef8229d2cd1a0cdc9ef8b42070697ec
https://doi.org/10.1021/acs.jmedchem.0c01973
https://doi.org/10.1021/acs.jmedchem.0c01973
Autor:
J. Michael McIntosh, Joanna Gajewiak, Lola Rueda-Ruzafa, Arik J. Hone, Almudena Albillos, Tino Dyhring, Thomas J. Gordon, Sean Christensen
Publikováno v:
J Neurochem
Adrenal chromaffin cells release neurotransmitters in response to stress and may be involved in conditions such as post-traumatic stress and anxiety disorders. Neurotransmitter release is triggered, in part, by activation of nicotinic acetylcholine r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97507ef81c745f8f27765b6a68424e95
https://doi.org/10.1111/jnc.14966
https://doi.org/10.1111/jnc.14966
Publikováno v:
International Journal of Environmental Research and Public Health
International Journal of Environmental Research and Public Health, Vol 18, Iss 1189, p 1189 (2021)
Investigo. Repositorio Institucional de la Universidade de Vigo
Universidade de Vigo (UVigo)
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
International Journal of Environmental Research and Public Health, Vol 18, Iss 1189, p 1189 (2021)
Investigo. Repositorio Institucional de la Universidade de Vigo
Universidade de Vigo (UVigo)
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
The gut-brain axis describes a complex interplay between the central nervous system and organs of the gastrointestinal tract. Sensory neurons of dorsal root and nodose ganglia, neurons of the autonomic nervous system, and immune cells collect and rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83cc6866bed490390864a5773dd1e8c2
http://hdl.handle.net/11093/2820
http://hdl.handle.net/11093/2820
Autor:
Lola Rueda-Ruzafa, José Medina-Polo, Carmen González-Enguita, Cristóbal de los Ríos, Sara Sanz-Lázaro, Arik J. Hone, Amanda Jiménez-Pompa, Almudena Albillos, Jesús Blázquez, J. Michael McIntosh
Publikováno v:
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
instname
Cardiovascular side effects of varenicline and a case report of a hypertensive crisis in a varenicline-prescribed patient with pheochromocytoma have been reported. The goal of the present study was to determine whether such side effects might derive,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d775eedc3dc0687c9695610b90e2fa2
https://doi.org/10.1016/j.neuropharm.2021.108632
https://doi.org/10.1016/j.neuropharm.2021.108632
Autor:
Arik J. Hone, J. Michael McIntosh
Publikováno v:
FEBS Letters. 592:1045-1062
Nicotinic acetylcholine receptors (nAChRs) are actively being investigated as therapeutic targets for the treatment of pain and inflammation, but despite more than 30 years of research, there are currently no FDA approved analgesics that target these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::381b7a9dc3e95a2a0b5745f061b05701
https://doi.org/10.1002/1873-3468.12884
https://doi.org/10.1002/1873-3468.12884
Autor:
David Larkin, Arik J. Hone, Sean Christensen, Joanna Gajewiak, Fernando Fisher, J. Michael McIntosh, Paul Whiteaker
Publikováno v:
J Med Chem
Pharmacologically distinguishing α3β2 nicotinic acetylcholine receptors (nAChRs) from closely related subtypes, particularly α6β2, has been challenging due to the lack of subtype-selective ligands. We created analogs of α-conotoxin (α-Ctx) PeIA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaa6de55c22789f4cdbc2d768b746577
https://pubmed.ncbi.nlm.nih.gov/31194549
https://pubmed.ncbi.nlm.nih.gov/31194549