Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Arijit Bhattacharya"'
Publikováno v:
Journal of Pure and Applied Microbiology, Vol 16, Iss 1, Pp 281-295 (2022)
Development of a suitable recombinant peptide vaccine against pathogens requires designing of effective immunogenic polypeptide taking various aspects and complexity of immune-response into consideration. Implementing SARS-CoV-2 spike glycoprotein (S
Externí odkaz:
https://doaj.org/article/fb03f15fbeb647f0aa5875e7a24291e3
Publikováno v:
Current Research in Pharmacology and Drug Discovery, Vol 5, Iss , Pp 100162- (2023)
Soil-Transmitted Helminthiasis (STH) is one of the most widespread Neglected Tropical Diseases (NTDs), and almost 1.5 billion of the global population is affected, mostly in the indigent, countryside sectors of tropics/subtropics. STH, commonly cause
Externí odkaz:
https://doaj.org/article/bed259c53a224e419289aca579042088
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Externí odkaz:
https://doaj.org/article/af7a85fc34a8476fa74e12c63920ab2f
Autor:
Supratim Pradhan, Snehlata, Debolina Manna, Subir Karmakar, Manoj Kumar Singh, Arijit Bhattacharya, Budhaditya Mukherjee, Joydeep Paul
Publikováno v:
Heliyon, Vol 8, Iss 7, Pp e09868- (2022)
Immunotherapeutic strategies against visceral leishmaniasis (VL) are pertinent because of the emergence of resistance against existing chemotherapy, coupled with their toxicity and high costs. Various bioactive components with potential immunomodulat
Externí odkaz:
https://doaj.org/article/f9a88dc19a7a48ac9fe1f9d7d597c77d
Autor:
Arijit Bhattacharya, Philippe Leprohon, Sophia Bigot, Prasad Kottayil Padmanabhan, Angana Mukherjee, Gaétan Roy, Hélène Gingras, Anais Mestdagh, Barbara Papadopoulou, Marc Ouellette
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Here, Bhattacharya et al. chemically mutagenize Leishmania and identify genes associated with resistance to miltefosine and paromomycin by next generation sequencing. The study shows that a protein kinase (CDPK1) can mediate resistance to paromomycin
Externí odkaz:
https://doaj.org/article/31297421268e443fb05fa40f1379e120
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 12, p e0010046 (2021)
Studies of drug resistance in the protozoan parasites of the genus Leishmania have been helpful in revealing biochemical pathways as potential drug targets. The chlorinated glutamine analogue acivicin has shown good activity against Leishmania cells
Externí odkaz:
https://doaj.org/article/128a0f2bbe6742f8863d7844f436ddbe
Autor:
Arijit Bhattacharya, Sophia Bigot, Prasad Kottayil Padmanabhan, Angana Mukherjee, Adriano Coelho, Philippe Leprohon, Barbara Papadopoulou, Marc Ouellette
Publikováno v:
Microbial Cell, Vol 7, Iss 2, Pp 59-61 (2020)
Leishmania parasites are responsible for a range of clinical manifestations ranging from self-resolving cutaneous sores to life-threatening diseases. The management of leishmaniasis is complicated in part by the scarcity of treatment options but also
Externí odkaz:
https://doaj.org/article/4bd8964260d14bd3ac8e8c6af9f14c0f
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 4, p e0009377 (2021)
Our understanding of folate metabolism in Leishmania has greatly benefited from studies of resistance to the inhibitor methotrexate (MTX). Folates are reduced in Leishmania by the bifunctional dihydrofolate reductase thymidylate synthase (DHFR-TS) an
Externí odkaz:
https://doaj.org/article/4e4305db51004982b34dd9dc99d8d119
Autor:
Amrita Saha, Anindita Bhattacharjee, Amit Vij, Pijush K. Das, Arijit Bhattacharya, Arunima Biswas
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
With the identification of novel cAMP binding effector molecules in Trypanosoma, the role of cAMP in kinetoplastida parasites gained an intriguing breakthrough. Despite earlier demonstrations of the role of cAMP in the survival of Leishmania during m
Externí odkaz:
https://doaj.org/article/8fe60348c2cb48b8af20363eff0cc739
Autor:
Arijit Bhattacharya, Mansi Sharma, Charles Packianathan, Barry P. Rosen, Philippe Leprohon, Marc Ouellette
Publikováno v:
mSystems, Vol 4, Iss 5 (2019)
ABSTRACT To further our understanding of one-carbon metabolism in the protozoan parasite Leishmania, we conducted genomic screens to study how the parasite responded to sinefungin (SNF) selection. SNF is a structural analogue of S-adenosylmethionine
Externí odkaz:
https://doaj.org/article/5a99ca2c131d4fb080e222bd46081b2d