Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Arijit A Adhikari"'
Autor:
Lina Yao, Sarah Craven Seaton, Sula Ndousse-Fetter, Arijit A Adhikari, Nicholas DiBenedetto, Amir I Mina, Alexander S Banks, Lynn Bry, A Sloan Devlin
Publikováno v:
eLife, Vol 7 (2018)
The human gut microbiota impacts host metabolism and has been implicated in the pathophysiology of obesity and metabolic syndromes. However, defining the roles of specific microbial activities and metabolites on host phenotypes has proven challenging
Externí odkaz:
https://doaj.org/article/e0f1b3fdb6ef4ee0a9f66c4b9d373d34
Autor:
Sandra Fernandes, Shea T. Meyer, Jigisha P. Shah, Arijit A. Adhikari, William G. Kerr, John D. Chisholm
Publikováno v:
Molecules, Vol 27, Iss 23, p 8451 (2022)
Inhibition of phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP) with small molecule inhibitors leads to apoptosis in tumor cells. Inhibitors that target both SHIP1 and SHIP2 (pan-SHIP1/2 inhibitors) may have benefits in these areas since
Externí odkaz:
https://doaj.org/article/87b28e05614c417d8cd52919f29322aa
Autor:
Lina Yao, Gabriel D. D’Agostino, Jinseok Park, Saiyu Hang, Arijit A. Adhikari, Yancong Zhang, Wei Li, Julian Avila-Pacheco, Sena Bae, Clary B. Clish, Eric A. Franzosa, Curtis Huttenhower, Jun R. Huh, A. Sloan Devlin
Publikováno v:
Nature Microbiology. 7:1404-1418
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd5b0768390a14cd19d037b3ed172615
https://doi.org/10.1038/s41564-022-01176-y
https://doi.org/10.1038/s41564-022-01176-y
Autor:
Arijit A. Adhikari, Megan D. McCurry, A. Sloan Devlin, Snehal N. Chaudhari, Deepti Ramachandran, Alexander S. Banks, Chelsea E. Powell, Wei Li
Publikováno v:
ACS Chem Biol
Bile acids play crucial roles in host physiology by acting as both detergents that aid in digestion and as signaling molecules that bind to host receptors. Gut bacterial bile salt hydrolase (BSH) enzymes perform the gateway reaction leading to the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ec86bd02213ac688357aaf7846ad7e
https://doi.org/10.1021/acschembio.1c00192
https://doi.org/10.1021/acschembio.1c00192
Autor:
Snehal N. Chaudhari, Raymond T. Chung, Yoojin Lee, A. Sloan Devlin, Darrick K. Li, Kenneth K. Tanabe, Arijit A. Adhikari, Stuti Shroff, Lawrence R. Zukerberg, Stephen Cole Barrett, Mozhdeh Sojoodi
Publikováno v:
Science advances. 8(34)
Altered host-microbe interactions and increased intestinal permeability have been implicated in the pathogenesis of a range of diseases. However, the mechanisms by which gut microbes affect epithelial barrier integrity remain unclear. Few host-produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4ff4da3ec5a1f4b8135d35ed773b104
https://pubmed.ncbi.nlm.nih.gov/36026454
https://pubmed.ncbi.nlm.nih.gov/36026454
Publikováno v:
Molecules, Vol 24, Iss 22, p 4143 (2019)
2-Substituted indoles may be directly transformed to 3,3-dialkyl indolenines with trichloroacetimidate electrophiles and the Lewis acid TMSOTf. These reactions provide rapid access to complex indolenines which are present in a variety of complex natu
Externí odkaz:
https://doaj.org/article/35772ebd60f94c5a9745a62866c13339
Autor:
Lina, Yao, Gabriel D, D'Agostino, Jinseok, Park, Saiyu, Hang, Arijit A, Adhikari, Yancong, Zhang, Wei, Li, Julian, Avila-Pacheco, Sena, Bae, Clary B, Clish, Eric A, Franzosa, Curtis, Huttenhower, Jun R, Huh, A Sloan, Devlin
Publikováno v:
Nature microbiology. 7(9)
Members of the human gut microbiome enzymatically process many bioactive molecules in the gastrointestinal tract. Most gut bacterial modifications characterized so far are hydrolytic or reductive in nature. Here we report that abundant human gut bact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::21ceb851381655c497dcd5544c1af305
https://pubmed.ncbi.nlm.nih.gov/35982309
https://pubmed.ncbi.nlm.nih.gov/35982309
Autor:
Daniel R. Wallach, Arijit A. Adhikari, John D. Chisholm, Alexandra M. Millimaci, Nivedita S. Mahajani, Sarah E Canarelli, Kyle T. Howard, Christopher M. Russo, Jigisha P. Shah, Rowan I. L. Meador, Tomas J Smith
Publikováno v:
J Org Chem
Trichloroacetimidates are useful reagents for the synthesis of esters under mild conditions that do not require an exogenous promoter. These conditions avoid the undesired decomposition of substrates with sensitive functional groups that are often ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c2e4b3e124931e443763dbe395fd8e
https://doi.org/10.1021/acs.joc.9b00745
https://doi.org/10.1021/acs.joc.9b00745
Autor:
Snehal N. Chaudhari, Alexander S. Banks, Chelsea E. Powell, Deepti Ramachandran, Megan D. McCurry, Arijit A. Adhikari, A. S. Devlin
Bile acids play crucial roles in host physiology by acting as both detergents that aid in digestion and as signaling molecules that bind to host receptors. Gut bacterial bile salt hydrolase (BSH) enzymes perform the gateway reaction leading to the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55ec71ed019f4a69fdba3d41a4e44c65
https://doi.org/10.1101/2021.03.15.435552
https://doi.org/10.1101/2021.03.15.435552
Autor:
Ashley H. Vernon, Donggi Paik, Scott T. Weiss, David A. Harris, Jun R. Huh, Hassan Aliakbarian, Ayşe Kılıç, Renuka Subramaniam, A. Sloan Devlin, Eric G. Sheu, Arijit A. Adhikari, Snehal N. Chaudhari, Lina Yao, James N. Luo
Publikováno v:
Cell hostmicrobe. 29(3)
Bariatric surgery is the most effective treatment for type 2 diabetes and is associated with changes in gut metabolites. Previous work uncovered a gut-restricted TGR5 agonist with anti-diabetic properties-cholic acid-7-sulfate (CA7S)-that is elevated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd18da588af5cc6890517ccc8dbb2d9f
https://pubmed.ncbi.nlm.nih.gov/33705701
https://pubmed.ncbi.nlm.nih.gov/33705701