Uncovering the mode of action of engineered T cells in patient cancer organoids.

Autor: Dekkers JF; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Utrecht, the Netherlands.; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Alieva M; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Cleven A; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Keramati F; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Wezenaar AKL; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., van Vliet EJ; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Puschhof J; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands.; Microbiome and Cancer Division, German Cancer Research Center, Heidelberg, Germany., Brazda P; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Johanna I; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Meringa AD; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Rebel HG; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Buchholz MB; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Barrera Román M; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Zeeman AL; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., de Blank S; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Fasci D; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Geurts MH; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Cornel AM; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Driehuis E; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Millen R; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Straetemans T; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.; Department of Hematology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Nicolasen MJT; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Aarts-Riemens T; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Ariese HCR; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Johnson HR; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., van Ineveld RL; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Karaiskaki F; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Kopper O; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Bar-Ephraim YE; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Kretzschmar K; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands.; Mildred Scheel Early Career Center for Cancer Research Würzburg, University Hospital Würzburg, MSNZ/IZKF, Wurzburg, Germany., Eggermont AMM; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; University Medical Center Utrecht, Utrecht, the Netherlands.; Comprehensive Cancer Center München, Munich, Germany., Nierkens S; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Wehrens EJ; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Stunnenberg HG; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Clevers H; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Utrecht, the Netherlands.; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Oncode Institute, Utrecht, the Netherlands.; Pharma, Research and Early Development, F. Hoffmann-La Roche Ltd, Basel, Switzerland., Kuball J; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.; Department of Hematology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Sebestyen Z; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Rios AC; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands. a.c.rios@prinsesmaximacentrum.nl.; Oncode Institute, Utrecht, the Netherlands. a.c.rios@prinsesmaximacentrum.nl.

Publikováno v: Nature biotechnology [Nat Biotechnol] 2023 Jan; Vol. 41 (1), pp. 60-69. Date of Electronic Publication: 2022 Jul 25.

LGR6 marks nephron progenitor cells.

Autor: van Ineveld RL; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Margaritis T; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Kooiman BAP; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Groenveld F; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center (UMC) Utrecht, Utrecht, The Netherlands., Ariese HCR; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Lijnzaad P; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Johnson HR; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Korving J; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center (UMC) Utrecht, Utrecht, The Netherlands., Wehrens EJ; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Holstege F; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., van Rheenen J; Oncode Institute, Utrecht, The Netherlands.; Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Drost J; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Rios AC; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Bos FL; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands.

Publikováno v: Developmental dynamics : an official publication of the American Association of Anatomists [Dev Dyn] 2021 Nov; Vol. 250 (11), pp. 1568-1583. Date of Electronic Publication: 2021 May 06.

High-resolution 3D imaging of fixed and cleared organoids.

Autor: Dekkers JF; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center (UMC) Utrecht, Utrecht, the Netherlands.; Department of Cancer Research, Oncode Institute, Hubrecht Institute-KNAW Utrecht, Utrecht, the Netherlands.; Cancer Genomics Center (CGC), Utrecht, the Netherlands., Alieva M; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Department of Cancer Research, Oncode Institute, Hubrecht Institute-KNAW Utrecht, Utrecht, the Netherlands.; Cancer Genomics Center (CGC), Utrecht, the Netherlands., Wellens LM; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Department of Cancer Research, Oncode Institute, Hubrecht Institute-KNAW Utrecht, Utrecht, the Netherlands.; Cancer Genomics Center (CGC), Utrecht, the Netherlands., Ariese HCR; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Department of Cancer Research, Oncode Institute, Hubrecht Institute-KNAW Utrecht, Utrecht, the Netherlands.; Cancer Genomics Center (CGC), Utrecht, the Netherlands., Jamieson PR; Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Vonk AM; Regenerative Medicine Center Utrecht, University Medical Center, Utrecht University, Utrecht, the Netherlands.; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, the Netherlands., Amatngalim GD; Regenerative Medicine Center Utrecht, University Medical Center, Utrecht University, Utrecht, the Netherlands.; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, the Netherlands., Hu H; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center (UMC) Utrecht, Utrecht, the Netherlands.; Department of Cancer Research, Oncode Institute, Hubrecht Institute-KNAW Utrecht, Utrecht, the Netherlands.; Cancer Genomics Center (CGC), Utrecht, the Netherlands., Oost KC; Department of Cancer Research, Oncode Institute, Hubrecht Institute-KNAW Utrecht, Utrecht, the Netherlands.; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Snippert HJG; Department of Cancer Research, Oncode Institute, Hubrecht Institute-KNAW Utrecht, Utrecht, the Netherlands.; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Beekman JM; Regenerative Medicine Center Utrecht, University Medical Center, Utrecht University, Utrecht, the Netherlands.; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, the Netherlands., Wehrens EJ; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Department of Cancer Research, Oncode Institute, Hubrecht Institute-KNAW Utrecht, Utrecht, the Netherlands.; Cancer Genomics Center (CGC), Utrecht, the Netherlands., Visvader JE; Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia., Clevers H; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center (UMC) Utrecht, Utrecht, the Netherlands.; Department of Cancer Research, Oncode Institute, Hubrecht Institute-KNAW Utrecht, Utrecht, the Netherlands.; Cancer Genomics Center (CGC), Utrecht, the Netherlands., Rios AC; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands. a.c.rios@prinsesmaximacentrum.nl.; Department of Cancer Research, Oncode Institute, Hubrecht Institute-KNAW Utrecht, Utrecht, the Netherlands. a.c.rios@prinsesmaximacentrum.nl.; Cancer Genomics Center (CGC), Utrecht, the Netherlands. a.c.rios@prinsesmaximacentrum.nl.

Publikováno v: Nature protocols [Nat Protoc] 2019 Jun; Vol. 14 (6), pp. 1756-1771. Date of Electronic Publication: 2019 May 03.