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Autor:
Suzanne M, Koopmans, Freek J, Bot, Harry C, Schouten, Jannie, Janssen, Arienne Mw, van Marion
Publikováno v:
American journal of blood research. 2(2)
In patients with myeloproliferative neoplasia (MPN) the development of fibrosis and increased vessel density correlate with poor prognosis. The JAK2(V617F) mutation constitutively activates JAK2, which phosphorylates signal transducer activator of tr