Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Arielle Shkedi"'
Autor:
Arielle Shkedi, Isabelle R. Taylor, Frank Echtenkamp, Poornima Ramkumar, Mohamed Alshalalfa, Génesis M. Rivera-Márquez, Michael A. Moses, Hao Shao, Robert Jeffrey Karnes, Len Neckers, Felix Feng, Martin Kampmann, Jason E. Gestwicki
Publikováno v:
Cell chemical biology, vol 29, iss 3
Cell Chem Biol
Cell Chem Biol
Castration-resistant prostate cancer (CRPC) is associated with an increased reliance on protein homeostasis (aka proteostasis) factors, such as heat shock protein 70 (Hsp70), but it is not clear what other factors might be involved. To address this q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03222de872ee905d788c1f9410516b16
https://escholarship.org/uc/item/3vc4z3sf
https://escholarship.org/uc/item/3vc4z3sf
Autor:
Hao Shao, Shuhei Taguwa, Luke Gilbert, Arielle Shkedi, Sara Sannino, Christopher J. Guerriero, Zachary J. Gale-Day, Zapporah T. Young, Jeffrey L. Brodsky, Jonathan Weissman, Jason E. Gestwicki, Judith Frydman
Publikováno v:
Cell chemical biology. 29(8)
The potential of small molecules to localize within subcellular compartments is rarely explored. To probe this question, we measured the localization of Hsp70 inhibitors using fluorescence microscopy. We found that even closely related analogs had dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d45ec1cf60ce50a889c13a138e8b8b17
https://pubmed.ncbi.nlm.nih.gov/35830852
https://pubmed.ncbi.nlm.nih.gov/35830852
Publikováno v:
The Journal of biological chemistry, vol 297, iss 5
The Journal of Biological Chemistry
The Journal of Biological Chemistry
The major classes of molecular chaperones have highly variable sequences, sizes, and shapes, yet they all bind to unfolded proteins, limit their aggregation, and assist in their folding. Despite the central importance of this process to protein homeo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b890469a9e8fdc14b702645f86d75b45
https://doi.org/10.1016/j.jbc.2021.101282
https://doi.org/10.1016/j.jbc.2021.101282
Autor:
Luke A. Gilbert, Christopher Yogodzinski, Danielle L. Swaney, Kevan M. Shokat, Arielle Shkedi, John D. Gordan, Veronica Steri, Y. Christina Hwang, Kevin Lou, Byron Hann, Dominique C. Mitchell, Alex Choi, Alex Y. Ge
Publikováno v:
Science Signaling. 12
Inhibitors targeting KRAS(G12C), a mutant form of the guanosine triphosphatase (GTPase) KRAS, are a promising new class of oncogene-specific therapeutics for the treatment of tumors driven by the mutant protein. These inhibitors react with the mutant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::168f3ff41ae6fb94d2c610fe0b5e4a39
https://doi.org/10.1126/scisignal.aaw9450
https://doi.org/10.1126/scisignal.aaw9450