Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ariella Zehender"'
Autor:
Ariella Zehender, Yi-Nan Li, Neng-Yu Lin, Adrian Stefanica, Julian Nüchel, Chih-Wei Chen, Hsiao-Han Hsu, Honglin Zhu, Xiao Ding, Jingang Huang, Lichong Shen, Andrea-Hermina Györfi, Alina Soare, Simon Rauber, Christina Bergmann, Andreas Ramming, Markus Plomann, Beate Eckes, Georg Schett, Jörg H. W. Distler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Uncontrolled activation of fibroblasts contributes to tissue fibrosis and organ dysfunction. Here the authors demonstrate that the epigenetic control of autophagy is disturbed by a TGFβ-dependent downregulation of MYST1 in systemic sclerosis patient
Externí odkaz:
https://doaj.org/article/62b5d5ace81c405bb445c8cf7e9725a7
Autor:
Ariella Zehender, Jingang Huang, Andrea-Hermina Györfi, Alexandru-Emil Matei, Thuong Trinh-Minh, Xiaohan Xu, Yi-Nan Li, Chih-Wei Chen, Jianping Lin, Clara Dees, Christian Beyer, Kolja Gelse, Zhong-Yin Zhang, Christina Bergmann, Andreas Ramming, Walter Birchmeier, Oliver Distler, Georg Schett, Jörg H. W. Distler
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Hyperactivation of TGFβ signaling is a common feature of fibrotic diseases. Here the authors show that genetic or pharmacologic inactivation of the tyrosine phosphatase SHP2 prevents TGFβ-induced JAK2/STAT3 signaling, inhibits fibroblast activation
Externí odkaz:
https://doaj.org/article/ca9d656a05724b31bfb9bc55df9634bf
Autor:
Chih-Wei Chen, Mirjana Ziemer, Christina Bergmann, Ariella Zehender, Jörg H W Distler, Alexander Kreuter, Xiang Zhou, Annemarie Schwab, Andrea Hermina Györfi, Sara Chenguiti Fakhouri, A. Brandt, Aline Bozec, L. Hallenberger, Clara Dees, Roland Coras, Debomita Chakraborty, B. Merlevede, Honglin Zhu, Georg Schett, Thuong Trinh-Minh, Simon Rauber, Alexandru-Emil Matei
Publikováno v:
Annals of the rheumatic diseases. 80(8)
ObjectiveX-linked inhibitor of apoptosis protein (XIAP) is a multifunctional protein with important functions in apoptosis, cellular differentiation and cytoskeletal organisation and is emerging as potential target for the treatment of various cancer
Autor:
Ariella, Zehender, Yi-Nan, Li, Neng-Yu, Lin, Adrian, Stefanica, Julian, Nüchel, Chih-Wei, Chen, Hsiao-Han, Hsu, Honglin, Zhu, Xiao, Ding, Jingang, Huang, Lichong, Shen, Andrea-Hermina, Györfi, Alina, Soare, Simon, Rauber, Christina, Bergmann, Andreas, Ramming, Markus, Plomann, Beate, Eckes, Georg, Schett, Jörg H W, Distler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications
Activation of fibroblasts is essential for physiological tissue repair. Uncontrolled activation of fibroblasts, however, may lead to tissue fibrosis with organ dysfunction. Although several pathways capable of promoting fibroblast activation and tiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::574afd08ae48f2b3043984f58e323446
https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/19463
https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/19463
Autor:
Alina Soare, Y. N. Li, Neng-Yu Lin, Christina Bergmann, Ariella Zehender, Andrea-Hermina Györfi, Georg Schett, J. H. W. Distler, Andreas Ramming
Publikováno v:
Annals of the Rheumatic Diseases. 80:1075.3-1075
Background:Autophagy is catabolic process allowing cells to degrade unnecessary or dysfunctional cellular organelles. Failure of appropriate regulation of autophagy, however, can severely perturb tissue homeostasis. Recent studies demonstrate that au
Autor:
Christina Bergmann, Neng-Yu Lin, Ariella Zehender, Andreas Ramming, Y. N. Li, J. H. W. Distler, Andrea-Hermina Györfi, Georg Schett
Publikováno v:
Annals of the Rheumatic Diseases. 79:1086.2-1087
Background:Autophagy is catabolic process allowing cells to degrade unnecessary or dysfunctional cellular organelles. Failure of appropriate regulation of autophagy, however, can severely perturb tissue homeostasis. Several stimuli present in fibrosi
Autor:
Andreas Ramming, Xiaohan Xu, Walter Birchmeier, Clara Dees, Jingang Huang, Chih-Wei Chen, Ariella Zehender, Yi Nan Li, Kolja Gelse, Christian Beyer, Jörg H W Distler, Georg Schett, Jian-Ping Lin, Andrea Hermina Györfi, Alexandru-Emil Matei, Christina Bergmann, Oliver Distler, Zhong Yin Zhang, Thuong Trinh-Minh
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Uncontrolled activation of TGFβ signaling is a common denominator of fibrotic tissue remodeling. Here we characterize the tyrosine phosphatase SHP2 as a molecular checkpoint for TGFβ-induced JAK2/STAT3 signaling and as a potential target for the tr
Autor:
J. Huang, Andrea-Hermina Györfi, Oliver Distler, Christian Beyer, W. Birchmeier, Ariella Zehender, Georg Schett, A. E. Matei, Andreas Ramming, Christina Bergmann, J. H. W. Distler, Kolja Gelse, Clara Dees
Publikováno v:
FRIDAY, 15 JUNE 2018.
Background SHP2, encoded by the PTPN11 gene, is a ubiquitously expressed non-receptor tyrosine phosphatase (PTP). Altered expression and activity levels of SHP2 have also been implicated into the pathogenesis of autoimmune diseases. Objectives In our
Autor:
Neng-Yu Lin, Oliver Distler, Alina Soare, Andreas Ramming, Adrian Stefanica, Thomas Wohlfahrt, Christina Bergmann, Simon Rauber, Ariella Zehender, J. H. W. Distler, Chih-Wei Chen
Publikováno v:
FRIDAY, 15 JUNE 2018.
Background Autophagy is catabolic process allowing cells to degrade unnecessary or dysfunctional cellular organelles. Aberrant activation of autophagy has been also implicated into the pathogenesis of fibrotic diseases. Several stimuli present in fib
Publikováno v:
Development genes and evolution. 227(5)
The Notch signaling pathway is highly conserved in all animal metazoa: upon Notch receptor activation, transcription of Notch target genes is turned on by an activator complex that centers on the transcription factor CSL. In the absence of signal, CS