Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Ariela Vergara-Jaque"'
Autor:
Adriana V. Treuer, Mario Faúndez, Roberto Ebensperger, Erwin Hovelmeyer, Ariela Vergara-Jaque, Yunier Perera-Sardiña, Margarita Gutierrez, Roberto Fuentealba, Daniel R. González
Publikováno v:
Antioxidants, Vol 12, Iss 7, p 1441 (2023)
NADPH oxidase (NOX2) is responsible for reactive oxygen species (ROS) production in neutrophils and has been recognized as a key mediator in inflammatory and cardiovascular pathologies. Nevertheless, there is a lack of specific NOX2 pharmacological i
Externí odkaz:
https://doaj.org/article/ed9cc055299c4cc596876ca39bf51734
Autor:
Mariela González-Avendaño, Simón Zúñiga-Almonacid, Ian Silva, Boris Lavanderos, Felipe Robinson, Roberto Rosales-Rojas, Fabio Durán-Verdugo, Wendy González, Mónica Cáceres, Oscar Cerda, Ariela Vergara-Jaque
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Mass spectrometry-based proteomics methods are widely used to identify and quantify protein complexes involved in diverse biological processes. Specifically, tandem mass spectrometry methods represent an accurate and sensitive strategy for identifyin
Externí odkaz:
https://doaj.org/article/78960793284e4ca297e733e472eecf61
Publikováno v:
BMC Plant Biology, Vol 19, Iss 1, Pp 1-16 (2019)
Abstract Background HKT channels mediate sodium uniport or sodium and potassium symport in plants. Monocotyledons express a higher number of HKT proteins than dicotyledons, and it is only within this clade of HKT channels that cation symport mechanis
Externí odkaz:
https://doaj.org/article/48eb2f59e8fa46beb56303bd27b3937a
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109639 (2014)
We have carried out a protocol in computational biochemistry including molecular dynamics (MD) simulations and MM/GBSA free energy calculations on the complex between the protein kinase A (PKA) and the specific peptide substrate Kemptide (LRRASLG). W
Externí odkaz:
https://doaj.org/article/7048ff035c7d47e9a518d40b3d2e431a
Autor:
Miguel Benítez‐Angeles, Ana E. López Romero, Itzel Llorente, Ileana Hernández‐Araiza, Ariela Vergara‐Jaque, Fernando H. Real, Óscar Eduardo Gutiérrez Castañeda, Marcelino Arciniega, Luis E. Morales‐Buenrostro, Francisco Torres‐Quiroz, Refugio García‐Villegas, Luis B. Tovar‐y‐Romo, Wolfgang B. Liedtke, León D. Islas, Tamara Rosenbaum
Publikováno v:
The Journal of Physiology. 601:1655-1673
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56b8faf49e97f4df6c1bf6b8e275febf
https://doi.org/10.1113/jp284262
https://doi.org/10.1113/jp284262
Autor:
Simona Collina, Dirk Schepmann, Giacomo Rossino, Pasquale Linciano, Mariela González-Avendaño, Julio Caballero, Bernhard Wünsch, Daniela Curti, Ariela Vergara-Jaque, Marco Peviani, Daniela Rossi, Massimo Boiocchi, Marta Rui, Elena Poggio
Publikováno v:
Journal of Medicinal Chemistry. 64:14997-15016
The sigma 1 receptor (S1R) is an enigmatic ligand-operated chaperone involved in many important biological processes, and its functions are not fully understood yet. Herein, we developed a novel series of bitopic S1R ligands as versatile tools to inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a35e9018b18fd9aa96b2e1611c1d54
https://doi.org/10.1021/acs.jmedchem.1c00886
https://doi.org/10.1021/acs.jmedchem.1c00886
Autor:
Daniel, Bustos, Erix W, Hernández-Rodríguez, Horacio, Poblete, Jans, Alzate-Morales, Cecilia, Challier, Cristhian, Boetsch, Ariela, Vergara-Jaque, Paola, Beassoni
Publikováno v:
Journal of chemical information and modeling. 62(12)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::022ef7e53aa9e38b197539a5c04c8da4
https://pubmed.ncbi.nlm.nih.gov/35670773
https://pubmed.ncbi.nlm.nih.gov/35670773
The accurate experimental estimation of residence time (τ) of protein-ligand systems has become very relevant in drug design projects (1) due to its importance in the last stages of refinement of the drug's pharmacodynamics and pharmacokinetics (2).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b8af6cded2c459ced6f0fd2480db64b
https://doi.org/10.26434/chemrxiv-2022-fw0x5
https://doi.org/10.26434/chemrxiv-2022-fw0x5
Autor:
Roberto Rosales-Rojas, Genoveva Rojas, Jeffrey Comer, Ivana Orellana, Jennie Garcia-Olivares, Ariela Vergara-Jaque
Publikováno v:
Journal of Chemical Information and Modeling. 60:3577-3586
Dopamine clearance in the brain is controlled by the dopamine transporter (DAT), a protein residing in the plasma membrane, which drives reuptake of extracellular dopamine into presynaptic neurons. Studies have revealed that the βγ subunits of hete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b556e159988ce3f3b80185bc60f3d37
https://doi.org/10.1021/acs.jcim.0c00236
https://doi.org/10.1021/acs.jcim.0c00236
Autor:
Alexander C.Y. Foo, Ikhuosho Asikhia, Ariela Vergara-Jaque, Samantha K. Sarkar, Angela Matyas, Tanja Kosenko, Thomas A. Lagace, Natalie K. Goto
Publikováno v:
The Journal of Biological Chemistry
Proprotein convertase subtilisin/kexin type-9 (PCSK9) is a ligand of low-density lipoprotein (LDL) receptor (LDLR) that promotes LDLR degradation in late endosomes/lysosomes. In human plasma, 30–40% of PCSK9 is bound to LDL particles; however, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::481f4569db516fc372524c2a466537e1
https://doi.org/10.1074/jbc.ra119.010221
https://doi.org/10.1074/jbc.ra119.010221