Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Ariel Ruiz i Altaba"'
Publikováno v:
Cell Reports, Vol 38, Iss 10, Pp 110490- (2022)
Summary: How metastatic cells arise is unclear. Here, we search for the induction of recently characterized pro-metastatic states as a surrogate for the origin of metastasis. Since cell-death-inducing therapies can paradoxically promote metastasis, w
Externí odkaz:
https://doaj.org/article/90c3409d083544adbe4f0dd4d75ddd5e
Autor:
Alice Melotti, Christophe Mas, Monika Kuciak, Aiala Lorente‐Trigos, Isabel Borges, Ariel Ruiz i Altaba
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 10, Pp 1263-1278 (2014)
Abstract Constitutive activation of canonical WNT‐TCF signaling is implicated in multiple diseases, including intestine and lung cancers, but there are no WNT‐TCF antagonists in clinical use. We have performed a repositioning screen for WNT‐TCF
Externí odkaz:
https://doaj.org/article/0847a9c96622445d943063c107ec027f
Autor:
Arnaud Duquet, Alice Melotti, Sonakshi Mishra, Monica Malerba, Chandan Seth, Arwen Conod, Ariel Ruiz i Altaba
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 7, Pp 882-901 (2014)
Abstract The progression of tumors to the metastatic state involves the loss of metastatic suppressor functions. Finding these, however, is difficult as in vitro assays do not fully predict metastatic behavior, and the majority of studies have used c
Externí odkaz:
https://doaj.org/article/9335cc5f8719458cbd007765a16efc97
Autor:
Chandan Seth, Ariel Ruiz I Altaba
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160904 (2016)
[This corrects the article DOI: 10.1371/journal.pone.0150697.].
Externí odkaz:
https://doaj.org/article/04a1403183e745fab5250f93a8227295
Autor:
Chandan Seth, Christophe Mas, Arwen Conod, Jens Mueller, Karsten Siems, Monika Kuciak, Isabel Borges, Ariel Ruiz I Altaba
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168170 (2016)
The WNT-TCF signaling pathway participates in adult tissue homeostasis and repair, and is hyperactive in a number of human diseases including cancers of the colon. Whereas to date there are no antagonists approved for patient use, a potential problem
Externí odkaz:
https://doaj.org/article/6c75967e282544b9b63179d43644bc9c
Autor:
Chandan Seth, Ariel Ruiz i Altaba
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150697 (2016)
Human colon cancers commonly harbor loss of function mutations in APC, a repressor of the canonical WNT pathway, thus leading to hyperactive WNT-TCF signaling. Re-establishment of Apc function in mice, engineered to conditionally repress Apc through
Externí odkaz:
https://doaj.org/article/28bb81c5faba4b90b3bb9d4fb82100d4
Autor:
Ariel Ruiz i Altaba, Grigori Singovski, Irene Siegl-Cachedenier, Arwen Conod, Carolina Bernal, Monika Kuciak
Publikováno v:
Journal of Molecular Cell Biology, Vol. 8, No 2 (2016) pp. 157-173
Journal of Molecular Cell Biology
Journal of Molecular Cell Biology
How metastases develop is not well understood and no genetic mutations have been reported as specific metastatic drivers. Here we have addressed the idea that epigenetic reprogramming by GLI-regulated pluripotent stemness factors promotes metastases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63f209083ffb40a9cef9fb6c13ec88d4
http://doc.rero.ch/record/331528/files/JMCB_8_2_157.pdf
http://doc.rero.ch/record/331528/files/JMCB_8_2_157.pdf
Autor:
Ariel Ruiz i Altaba, Carolina Bernal, Santosh Anand, Marianna Silvano, Yann Tapponnier, Cecilia Angulo
Publikováno v:
Cell Reports, Vol. 33, No 6 (2020) P. 108372
How cells with metastatic potential, or pro-metastatic states, arise within heterogeneous primary tumors remains unclear. Here, we have used one index primary colon cancer to develop spiked-scRNAseq to link omics-defined single-cell clusters with cel
Publikováno v:
Scientific Reports, Vol. 9, No 1 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Repisalud
Instituto de Salud Carlos III (ISCIII)
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Repisalud
Instituto de Salud Carlos III (ISCIII)
Scientific Reports
Targeting stemness promises new therapeutic strategies against highly invasive tumors. While a number of approaches are being tested, inhibiting the core transcription regulatory network of cancer stem cells is an attractive yet challenging possibili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aeb02ca5ac738b982773de8a337c793
https://archive-ouverte.unige.ch/unige:116909
https://archive-ouverte.unige.ch/unige:116909
Publikováno v:
Oncogene, Vol. 38, No 29 (2019) pp. 5817-5837
Oncogene
Oncogene
How cells in primary tumors initially become pro-metastatic is not understood. A previous genome-wide RNAi screen uncovered colon cancer metastatic suppressor and WNT promoting functions of TMED3, a member of the p24 ER-to-Golgi protein secretion fam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac572a7be7e441993208bb7d962c3d9
https://archive-ouverte.unige.ch/unige:123163
https://archive-ouverte.unige.ch/unige:123163