Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ariel Raybuck"'
Autor:
Mark R. Boothby, Ariel Raybuck, Sung Hoon Cho, Kristy R. Stengel, Volker H. Haase, Scott Hiebert, Jingxin Li
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Accumulating evidence suggests that many immune responses are influenced by local nutrient concentrations in addition to the programming of intermediary metabolism within immune cells. Humoral immunity and germinal centers (GC) are settings in which
Externí odkaz:
https://doaj.org/article/1145f66379824603aee1bae944a95adf
Autor:
Xingxing Zhu, Xian Zhou, Chaofan Li, Yanfeng Li, Jie Sun, Ariel Raybuck, Mark Robin Boothby, Hu Zeng
Publikováno v:
The Journal of Immunology. 208:112.03-112.03
The humoral immune response requires that B cells undergo a rapid metabolic shift and high demand of nutrients, which are vital to sustain the formation of germinal center. Rag GTPase senses amino acid availability to activate mechanistic target of r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e983be38ff40bfed6017de5a73f05b3c
https://doi.org/10.4049/jimmunol.208.supp.112.03
https://doi.org/10.4049/jimmunol.208.supp.112.03
Autor:
James W. Thomas, Emmanuel J. Volanakis, Kristy R. Stengel, Thomas C. Beck, Ariel Raybuck, Scott W. Hiebert, Mark Boothby, Volker H. Haase, Sung Hoon Cho, Mei Wei
Publikováno v:
Nature
Germinal centres (GCs) promote humoral immunity and vaccine efficacy. In GCs, antigen-activated B cells proliferate, express high-affinity antibodies, promote antibody class switching, and yield B cell memory. Whereas the cytokine milieu has long bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::735b7a5a908798006341b81493b68291
https://doi.org/10.1038/nature19334
https://doi.org/10.1038/nature19334
Publikováno v:
Immunity
Summary Expansion and acquisition of Th1 cell effector function requires metabolic reprogramming; however, the signals instructing these adaptations remain poorly defined. Here we found that in activated human T cells, autocrine stimulation of the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1688011c12844e61f158690427ee79d9
Publikováno v:
The Journal of Immunology. 200:48.20-48.20
Germinal centers (GCs) are micronantomic structures that B cells proliferate, are selected for affinity maturation, undergo antibody (Ab) class-switch recombination and differentiate into Ab-secreting plasma cells and memory B cells. Both cell-autono
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8aea5bfec4256f1504cd9514b52f3449
https://doi.org/10.4049/jimmunol.200.supp.48.20
https://doi.org/10.4049/jimmunol.200.supp.48.20
Publikováno v:
The Journal of Immunology. 198:195.13-195.13
B lymphocytes migrate among different micro-anatomic sites for diversification, selection, and eventual differentiation into antibody-secreting plasma cells. Emerging evidence supports the premise that aspects of the nutrient milieu vary within lymph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f722d689fe4a6fa6fce86982c698fbc9
https://doi.org/10.4049/jimmunol.198.supp.195.13
https://doi.org/10.4049/jimmunol.198.supp.195.13
Autor:
Sung Hoon Cho, Mark Boothby, Lindsey Heffington, Robert C. Rickert, Ki Taek Nam, Julia Jellusova, Keunwook Lee, James W. Thomas, Ariel Raybuck
Publikováno v:
Blood. 122(14)
The mammalian target of rapamycin (mTOR), an essential serine/threonine kinase, functions in biochemically distinct multiprotein complexes, but little is known about roles of the complexes in B cells. The acutely rapamycin-sensitive mTOR complex 1 (m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::535ed7eb9832a13e2303c7997de4ef94
https://pubmed.ncbi.nlm.nih.gov/23958952
https://pubmed.ncbi.nlm.nih.gov/23958952
Autor:
Mei Wei, Sung Hoon Cho, Reagan G. Cox, James W. Thomas, Ki Taek Nam, John J. Erickson, Alyssa Trochtenberg, Mark Boothby, Ariel Raybuck, John V. Williams
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 191(6)
The capacity to achieve sufficient concentrations of Ag-specific Ab of the appropriate isotypes is a critical component of immunity that requires efficient differentiation and interactions of Ag-specific B and Th cells along with dendritic cells. Num
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdbe793b4f38a65f71be34713847c92c
https://pubmed.ncbi.nlm.nih.gov/23956424
https://pubmed.ncbi.nlm.nih.gov/23956424
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