Výsledky vyhledávání - "Ariel Mizrahi"

Tripartite Chimeras Comprising Functional Domains Derived from the Cytosolic NADPH Oxidase Components p47 , p67 , and Rac1 Elicit Activator-independent Superoxide Production by Phagocyte Membranes

Autor: Yelena Ugolev, Shahar Molshanski-Mor, Yevgeny Berdichevsky, Ariel Mizrahi, Edgar Pick

Publikováno v: Journal of Biological Chemistry. 282:22122-22139

The superoxide-generating NADPH oxidase is converted to an active state by the assembly of a membrane-localized cytochrome b(559) with three cytosolic components: p47(phox), p67(phox), and GTPase Rac1 or Rac2. Assembly involves two sets of protein-pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8f9eef2ca617aace7ec8044f9da1caf
https://doi.org/10.1074/jbc.m701497200

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Assembly of the phagocyte NADPH oxidase complex: chimeric constructs derived from the cytosolic components as tools for exploring structure-function relationships

Autor: Yevgeny Berdichevsky, Shahar Molshanski-Mor, Yara Gorzalczany, Iris Dahan, Miriam Hirshberg, Nathalie Alloul, Rive Sarfstein, Yael Nakash, Yelena Ugolev, Edgar Pick, Ariel Mizrahi

Publikováno v: Journal of Leukocyte Biology. 79:881-895

Phagocytes generate superoxide (O2.−) by an enzyme complex known as reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. Its catalytic component, responsible for the NADPH-driven reduction of oxygen to O2.−, is flavocytochrome b55

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca9a12c1f47022e61e08e3b76ce9c26
https://doi.org/10.1189/jlb.1005553

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Activation of the Phagocyte NADPH Oxidase by Rac Guanine Nucleotide Exchange Factors in Conjunction with ATP and Nucleoside Diphosphate Kinase

Autor: Carolyn Weinbaum, Shahar Molshanski-Mor, Ariel Mizrahi, Miriam Hirshberg, Yi Zheng, Edgar Pick

Publikováno v: Journal of Biological Chemistry. 280:3802-3811

Activation of the phagocyte NADPH oxidase is the consequence of the assembly of membranal cytochrome b559 with the cytosolic components p47phox, p67phox, and the GTPase Rac and is mimicked by a cell-free system comprising these components and an acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318c6d5cfc8d276c076befad9214dc1b
https://doi.org/10.1074/jbc.m410257200

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Dual Role of Rac in the Assembly of NADPH Oxidase, Tethering to the Membrane and Activation of p67

Autor: Carolyn Weinbaum, Yara Gorzalczany, Ariel Mizrahi, Miriam Hirshberg, Shahar Molshanski-Mor, Rive Sarfstein, Edgar Pick, Marie-Claire Dagher, Yevgeny Berdichevsky

Publikováno v: Journal of Biological Chemistry. 279:16007-16016

NADPH oxidase activation involves the assembly of membrane-localized cytochrome b559 with the cytosolic components p47phox, p67phox, and the small GTPase Rac. Assembly is mimicked by a cell-free system consisting of membranes and cytosolic components

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e3520bf0e7c3815452ff9c30f50d4afd
https://doi.org/10.1074/jbc.m312394200

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Rational design of small molecule inhibitors targeting the Rac GTPase - p67phox signaling axis in inflammation

Autor: Jacek Biesiada, Jarek Meller, William L. Seibel, Yi Zheng, Sachin Kumar, Kathleen Szczur, Ariel Mizrahi, Marie-Dominique Filippi, Filippo Marchioni, Mirosław Kordos, Edgar Pick, Emily E. Bosco

Summary The NADPH oxidase enzyme complex, NOX2, is responsible for reactive oxygen species production in neutrophils and has been recognized as a key mediator of inflammation. Here, we have performed rational design and in silico screen to identify a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baadaaabe1321dd53d925e712b077e53
https://europepmc.org/articles/PMC3292765/

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A prenylated p47phox-p67phox-Rac1 chimera is a Quintessential NADPH oxidase activator: membrane association and functional capacity

Autor: Ariel, Mizrahi, Yevgeny, Berdichevsky, Patrick J, Casey, Edgar, Pick

Publikováno v: The Journal of biological chemistry. 285(33)

The superoxide-generating NADPH oxidase complex of resting phagocytes includes cytochrome b(559), a membrane-associated heterodimer composed of two subunits (Nox2 and p22(phox)), and four cytosolic proteins (p47(phox), p67(phox), Rac, and p40(phox)).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aaada6e73ed2f32b2f3e35f9ef18a04b
https://pubmed.ncbi.nlm.nih.gov/20529851

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Cell-free assays: the reductionist approach to the study of NADPH oxidase assembly, or 'all you wanted to know about cell-free assays but did not dare to ask'

Autor: Shahar, Molshanski-Mor, Ariel, Mizrahi, Yelena, Ugolev, Iris, Dahan, Yevgeny, Berdichevsky, Edgar, Pick

Publikováno v: Methods in molecular biology (Clifton, N.J.). 412

The superoxide (O2-)-generating enzyme complex of phagocytes, known as the NADPH oxidase, can be assayed in a number of in vitro cell-free (or broken cell) systems. These consist of a mixture of the individual components of the NADPH oxidase, derived

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::905d9711b043ec19a28c1fc4ad7e6c65
https://pubmed.ncbi.nlm.nih.gov/18453125

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Tripartite chimeras comprising functional domains derived from the cytosolic NADPH oxidase components p47phox, p67phox, and Rac1 elicit activator-independent superoxide production by phagocyte membranes: an essential role for anionic membrane phospholipids

Autor: Yevgeny, Berdichevsky, Ariel, Mizrahi, Yelena, Ugolev, Shahar, Molshanski-Mor, Edgar, Pick

Publikováno v: The Journal of biological chemistry. 282(30)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f512da134a481025666048eee32acce5
https://pubmed.ncbi.nlm.nih.gov/17548354

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