Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Ariel M, Silber"'
Autor:
Janaina F Nascimento, Rodolpho O O Souza, Mayke B Alencar, Sabrina Marsiccobetre, Ana M Murillo, Flávia S Damasceno, Richard B M M Girard, Letícia Marchese, Luis A Luévano-Martinez, Renan W Achjian, Jurgen R Haanstra, Paul A M Michels, Ariel M Silber
Publikováno v:
PLoS Pathogens, Vol 19, Iss 7, p e1011522 (2023)
ATP hydrolysis is required for the synthesis, transport and polymerization of monomers for macromolecules as well as for the assembly of the latter into cellular structures. Other cellular processes not directly related to synthesis of biomass, such
Externí odkaz:
https://doaj.org/article/b300e612613c444584a3f2ac2fc20f2f
Autor:
Denis Amilton dos Santos, Higo Fernando Santos Souza, Ariel M. Silber, Tatiana de Arruda Campos Brasil de Souza, Andréa Rodrigues Ávila
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
The apicomplexan parasite Toxoplasma gondii is the causative agent of toxoplasmosis, a global disease that significantly impacts human health. The clinical manifestations are mainly observed in immunocompromised patients, including ocular damage and
Externí odkaz:
https://doaj.org/article/1704539244e44e578a87b8fefa200e5d
Autor:
Alex Ranieri Jerônimo Lima, Herbert Guimarães de Sousa Silva, Saloe Poubel, Juliana Nunes Rosón, Loyze Paola Oliveira de Lima, Héllida Marina Costa-Silva, Camila Silva Gonçalves, Pedro A. F. Galante, Fabiola Holetz, Maria Cristina Machado M. Motta, Ariel M. Silber, M. Carolina Elias, Julia Pinheiro Chagas da Cunha
Publikováno v:
Epigenetics & Chromatin, Vol 15, Iss 1, Pp 1-16 (2022)
Abstract Background Genomic organization and gene expression regulation in trypanosomes are remarkable because protein-coding genes are organized into codirectional gene clusters with unrelated functions. Moreover, there is no dedicated promoter for
Externí odkaz:
https://doaj.org/article/9a574499a4724a0987c9f2e9697fd782
Autor:
Mustafa M. Aldfer, Ibrahim A. Alfayez, Hamza A. A. Elati, Nilanjana Gayen, Ehab Kotb Elmahallawy, Ana Milena Murillo, Sabrina Marsiccobetre, Serge Van Calenbergh, Ariel M. Silber, Harry P. de Koning
Publikováno v:
Molecules, Vol 27, Iss 22, p 8045 (2022)
Among the scarce validated drug targets against Chagas disease (CD), caused by Trypanosoma cruzi, the parasite’s nucleoside salvage system has recently attracted considerable attention. Although the trypanocidal activity of tubercidin (7-deazapurin
Externí odkaz:
https://doaj.org/article/dcdfd03943c144409fdee59cfd36c9d5
Autor:
Alex Ranieri Jerônimo Lima, Herbert Guimarães de Sousa Silva, Saloe Bispo Poubel, Juliana Nunes Rosón, Loyze Paola Oliveira de Lima, Héllida Marina Costa-Silva, Camila Silva Gonçalves, Pedro A. F. Galante, Fabiola Holetz, Maria Cristina Machado Motta, Ariel M. Silber, M. Carolina Elias, Julia Pinheiro Chagas da Cunha
Publikováno v:
Epigenetics & Chromatin, Vol 15, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/ab688f51343f435580d81d43092b3559
Autor:
Oriana Villafraz, Marc Biran, Erika Pineda, Nicolas Plazolles, Edern Cahoreau, Rodolpho Ornitz Oliveira Souza, Magali Thonnus, Stefan Allmann, Emmanuel Tetaud, Loïc Rivière, Ariel M Silber, Michael P Barrett, Alena Zíková, Michael Boshart, Jean-Charles Portais, Frédéric Bringaud
Publikováno v:
PLoS Pathogens, Vol 17, Iss 3, p e1009204 (2021)
Trypanosoma brucei, a protist responsible for human African trypanosomiasis (sleeping sickness), is transmitted by the tsetse fly where the procyclic forms of the parasite develop in the proline-rich (1-2 mM) and glucose-depleted digestive tract. Pro
Externí odkaz:
https://doaj.org/article/1885a736cc92490ba8841d001d3da10c
Publikováno v:
Anais da Academia Brasileira de Ciências, Vol 93, Iss 1 (2021)
Abstract Scientists are facing enormous pressures posed by growing scientific communities and stagnant/reduced funding. In this scenario, mechanisms of knowledge achievement and management, as well as how recruitment, progression and evaluation are c
Externí odkaz:
https://doaj.org/article/f1dd6fa58946403a829630d54f5816ce
Autor:
Alex R J Lima, Christiane B de Araujo, Saloe Bispo, José Patané, Ariel M Silber, M Carolina Elias, Julia P C da Cunha
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009272 (2021)
Trypanosoma cruzi alternates between replicative and nonreplicative life forms, accompanied by a shift in global transcription levels and by changes in the nuclear architecture, the chromatin proteome and histone posttranslational modifications. To g
Externí odkaz:
https://doaj.org/article/cea4b7a6685b4357a6b7827db7f6fe28
Autor:
Isabel S Shiratsubaki, Xin Fang, Rodolpho O O Souza, Bernhard O Palsson, Ariel M Silber, Jair L Siqueira-Neto
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008728 (2020)
Chagas disease is a neglected tropical disease and a leading cause of heart failure in Latin America caused by a protozoan called Trypanosoma cruzi. This parasite presents a complex multi-stage life cycle. Anti-Chagas drugs currently available are li
Externí odkaz:
https://doaj.org/article/84a796d0ce1148a1bb855932c99ffcc9
Autor:
Lucía Fargnoli, Esteban A. Panozzo-Zénere, Lucas Pagura, María Julia Barisón, Julia A. Cricco, Ariel M. Silber, Guillermo R. Labadie
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
L-Proline is an important amino acid for the pathogenic protists belonging to Trypanosoma and Leishmania genera. In Trypanosoma cruzi, the etiological agent of Chagas disease, this amino acid is involved in fundamental biological processes such as AT
Externí odkaz:
https://doaj.org/article/5c0cae08d1194a9c8f5a46a1bca16f0c