Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ariel Lefkovith"'
Autor:
Jiarui Ding, John J. Garber, Amiko Uchida, Ariel Lefkovith, Grace T. Carter, Praveen Vimalathas, Lauren Canha, Michael Dougan, Kyle Staller, Joseph Yarze, Toni M. Delorey, Orit Rozenblatt-Rosen, Orr Ashenberg, Daniel B. Graham, Jacques Deguine, Aviv Regev, Ramnik J. Xavier
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Coordinated cell interactions within the esophagus maintain homeostasis, and disruption can lead to eosinophilic esophagitis (EoE), a chronic inflammatory disease with poorly understood pathogenesis. We profile 421,312 individual cells from
Externí odkaz:
https://doaj.org/article/0442cca45bfc4b01b6f06f0a4b36b4f3
Autor:
Lingjia Kong, Simone J.C.F.M. Moorlag, Ariel Lefkovith, Bihua Li, Vasiliki Matzaraki, Liesbeth van Emst, Heather A. Kang, Isabel Latorre, Martin Jaeger, Leo A.B. Joosten, Mihai G. Netea, Ramnik J. Xavier
Publikováno v:
Cell Reports, Vol 37, Iss 7, Pp 110028- (2021)
Summary: Bacillus Calmette-Guérin (BCG) vaccine is one of the most widely used vaccines worldwide. In addition to protection against tuberculosis, BCG confers a degree of non-specific protection against other infections by enhancing secondary immune
Externí odkaz:
https://doaj.org/article/d017840185dc456fa97a51273e8b4236
Autor:
Johannes F. Scheid, Basak Eraslan, Andrew Hudak, Eric M. Brown, Dallis Sergio, Toni M. Delorey, Devan Phillips, Ariel Lefkovith, Alison T. Jess, Lennard W. Duck, Charles O. Elson, Hera Vlamakis, Damian R. Plichta, Jacques Deguine, Ashwin N. Ananthakrishnan, Daniel B. Graham, Aviv Regev, Ramnik J. Xavier
Publikováno v:
Journal of Experimental Medicine. 220
Plasma cells (PCs) constitute a significant fraction of colonic mucosal cells and contribute to inflammatory infiltrates in ulcerative colitis (UC). While gut PCs secrete bacteria-targeting IgA antibodies, their role in UC pathogenesis is unknown. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51c9524b9243391c2f98718d67bd111c
https://doi.org/10.1084/jem.20220538
https://doi.org/10.1084/jem.20220538
Autor:
Motohiko Kadoki, Daniel B. Graham, Mark J. Daly, Ariel Lefkovith, Helen Lin, Toru Nakata, Martin K. Selig, Elizabeth A. Creasey, Junmei Yao, Ramnik J. Xavier
Publikováno v:
Proceedings of the National Academy of Sciences. 117:28930-28938
Common genetic variants interact with environmental factors to impact risk of heritable diseases. A notable example of this is a single-nucleotide variant in the Solute Carrier Family 39 Member 8 (SLC39A8) gene encoding the missense variant A391T, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63ab7b42536d24969bc6ff919e629c4e
https://doi.org/10.1073/pnas.2014742117
https://doi.org/10.1073/pnas.2014742117
Autor:
Lingjia Kong, Vladislav Pokatayev, Ariel Lefkovith, Grace T. Carter, Elizabeth A. Creasey, Chirag Krishna, Sathish Subramanian, Bharati Kochar, Orr Ashenberg, Helena Lau, Ashwin N. Ananthakrishnan, Daniel B. Graham, Jacques Deguine, Ramnik J. Xavier
Publikováno v:
Immunity. 56:444-458.e5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ee4171f12e8c316a39c7fc6fe131ca4
https://doi.org/10.1016/j.immuni.2023.01.002
https://doi.org/10.1016/j.immuni.2023.01.002
Autor:
Jennifer E. Towne, Toru Nakata, Ariel Lefkovith, Chih Hung Chou, Ramnik J. Xavier, Aviv Regev, Lingfei Wang, Daniel B. Graham, Kai Liu, Junmei Yao, Alok Jaiswal, Kwontae You, Jacqueline Perrigoue, Abdifatah S. Omar
Publikováno v:
Science
Transcriptional control of proteostasis Tissue homeostasis requires the coordinated activity of multiple cell types to initiate and then resolve inflammation. Intrinsic cellular stress-response pathways facilitate adaptation to stress and tissue rest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b91fbf3e3013e227bf82e52d8669a9f4
https://europepmc.org/articles/PMC8315080/
https://europepmc.org/articles/PMC8315080/
Autor:
Toru, Nakata, Elizabeth A, Creasey, Motohiko, Kadoki, Helen, Lin, Martin K, Selig, Junmei, Yao, Ariel, Lefkovith, Mark J, Daly, Daniel B, Graham, Ramnik J, Xavier
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance SLC39A8 A391T exhibits remarkable pleiotropic effects on multiple conditions, including cardiovascular diseases, Parkinson’s disease, and Crohn’s disease. However, how this single coding variant impacts such a wide range of pathologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::70d264ee6a4da04b282663fb8bc46b82
https://pubmed.ncbi.nlm.nih.gov/33139556
https://pubmed.ncbi.nlm.nih.gov/33139556
Autor:
Bihua Li, Liesbeth van Emst, Isabel J. Latorre, Leo A. B. Joosten, Heather A. Kang, Vasiliki Matzaraki, Ramnik J. Xavier, Mihai G. Netea, Lingjia Kong, Simone J.C.F.M. Moorlag, Ariel Lefkovith, Martin Jaeger
Publikováno v:
Cell Reports, 37, 7
Cell Rep
Cell Reports, 37
Cell Reports, Vol 37, Iss 7, Pp 110028-(2021)
Cell Rep
Cell Reports, 37
Cell Reports, Vol 37, Iss 7, Pp 110028-(2021)
Summary Bacillus Calmette-Guerin (BCG) vaccine is one of the most widely used vaccines worldwide. In addition to protection against tuberculosis, BCG confers a degree of non-specific protection against other infections by enhancing secondary immune r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52719b08df3cad238ea049c041e500c2
https://doi.org/10.1016/j.celrep.2021.110028
https://doi.org/10.1016/j.celrep.2021.110028
Autor:
Patrick Deelen, Niek de Klein, Cisca Wijmenga, Mark J. Daly, Christine P. Petersen, Mukund Varma, A. Nicole Desch, Ramnik J. Xavier, Steven A. Carr, Gaelen Guzman, Aylwin Ng, Daniel B. Graham, Atul K. Bhan, Angela C. Boroughs, Ariel Lefkovith, Manuel A. Rivas, Monica Schenone
Publikováno v:
Elsevier
Cell reports, 17(11), 2955-2965. CELL PRESS
Cell reports, 17(11), 2955-2965. CELL PRESS
Summary - Significant insights into disease pathogenesis have been gleaned from population-level genetic studies; however, many loci associated with complex genetic disease contain numerous genes, and phenotypic associations cannot be assigned unequi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d710d20be7f85a400bfee0437d6a8ec0
https://research.rug.nl/en/publications/cb1a6faf-c419-47f1-bb78-5767a47023ee
https://research.rug.nl/en/publications/cb1a6faf-c419-47f1-bb78-5767a47023ee
Autor:
Aviv Regev, Antonia Wallrapp, Jiarui Ding, Orit Rozenblatt-Rosen, Samantha J. Riesenfeld, Sai Ma, Shujie Fu, Patrick R. Burkett, Chien-wen Su, Hai Ning Shi, Daniel B. Graham, Danielle Dionne, Vijay K. Kuchroo, Marcin Tabaka, Caroline B. M. Porter, Xu Heping, Lan T. Nguyen, Orr Ashenberg, Ramnik J. Xavier, Xuanxuan Guo, Ariel Lefkovith
Publikováno v:
Prof. Regev via Courtney Crummett
Summary Signaling abnormalities in immune responses in the small intestine can trigger chronic type 2 inflammation involving interaction of multiple immune cell types. To systematically characterize this response, we analyzed 58,067 immune cells from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::207acc737e8ef0bcf7f8ea4c72c906c2
https://hdl.handle.net/1721.1/126748
https://hdl.handle.net/1721.1/126748