Suppression of Slit3 induces tumor proliferation and chemoresistance in hepatocellular carcinoma through activation of GSK3β/β-catenin pathway

Autor: Thomas Yau, Roberta Pang, Johnny Hon Wai Man, Ariel K.M. Chow, Lui Ng, Ronnie Tung-Ping Poon, Deepak Narayanan Iyer, Wai Lun Law, Timothy Ming-Hun Wan, Virginia H. T. Kwan

Publikováno v: BMC Cancer, Vol 18, Iss 1, Pp 1-13 (2018)
BMC Cancer

Background It is essential to understand the mechanisms responsible for hepatocellular carcinoma (HCC) progression and chemoresistance in order to identify prognostic biomarkers as well as potential therapeutic avenues. Recent findings have shown tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f012e84ffc5ab86850884fc45f7e2e
http://link.springer.com/article/10.1186/s12885-018-4326-5

Emergence of CD26+ Cancer Stem Cells with Metastatic Properties in Colorectal Carcinogenesis

Autor: Roberta Pang, Hung-Sing Lee, Wai Lun Law, Ariel K.M. Chow, Lui Ng, Timothy Ming-Hun Wan, Colin S.C. Lam, Johnny Hon Wai Man, Ronnie T.P. Poon, SK Wong, Alvin K.H. Cheung, Deepak Narayanan Iyer

Publikováno v: International Journal of Molecular Sciences, Vol 18, Iss 6, p 1106 (2017)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 18; Issue 6; Pages: 1106

Colorectal cancer results from genetic aberrations which accumulate over a long period of time, with malignant and metastatic properties acquired at a relatively late stage. A subpopulation of CD26+ colorectal cancer stem cells are known to be implic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ece9bebf72a98967c8898a3a67bedfc
http://www.mdpi.com/1422-0067/18/6/1106

Identification of serum miR-139-3p as a non-invasive biomarker for colorectal cancer

Autor: Ariel K.M. Chow, Thomas Yau, Wai Lun Law, Roberta Pang, Oswens Siu-Hung Lo, Johnny Hon Wai Man, Timothy Ming-Hun Wan, Guanghua Chen, Dominic Chi-Chung Foo, Deepak Narayanan Iyer, Wai-Keung Leung, Lui Ng, Jensen T. C. Poon

Publikováno v: Oncotarget

// Lui Ng 1, * , Timothy Ming-Hun Wan 1, * , Johnny Hon-Wai Man 1 , Ariel Ka-Man Chow 1 , Deepak Iyer 1 , Guanghua Chen 1 , Thomas Chung-Cheung Yau 2 , Oswens Siu-Hung Lo 1 , Dominic Chi-Chung Foo 1 , Jensen Tung-Chung Poon 1 , Wai-Keung Leung 3 , Ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c7ae7a8ddea3b4cb10162913b4dd17
https://pubmed.ncbi.nlm.nih.gov/28404964

A Subpopulation of CD26+ Cancer Stem Cells with Metastatic Capacity in Human Colorectal Cancer

Autor: Lui Ng, Leonard Wing-Hong Cheung, Wai Lun Law, Benjamin C. Y. Wong, Colin S.C. Lam, Andrew C.Y. Chu, Ariel K.M. Chow, Hui Y. Lan, Thomas Yau, Ronnie Tung-Ping Poon, Xiao R. Lan, Victoria P.Y. Tan, J. T. C. Poon, Roberta Pang

Publikováno v: Cell Stem Cell. 6:603-615

Recent evidence suggests that a subpopulation of cancer cells, cancer stem cells (CSCs), is responsible for tumor growth in colorectal cancer. However, the role of CSCs in colorectal cancer metastasis is unclear. Here, we identified a subpopulation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4383244e5c354b944967ae63c334d59c
https://doi.org/10.1016/j.stem.2010.04.001

Preclinical analysis of the anti-tumor and anti-metastatic effects of Raf265 on colon cancer cells and CD26(+) cancer stem cells in colorectal carcinoma

Autor: Jensen T. C. Poon, Lui Ng, Thomas Yau, Timothy Ming-Hun Wan, Alvin Ho Kwan Cheung, Ariel K.M. Chow, Johnny Hon Wai Man, Wai Lun Law, Sunny Kit Man Wong, Colin S.C. Lam, Nathan Shiu Man Cheng, Roberta Pang

Publikováno v: Molecular Cancer

© 2015 Chow et al.Background: In colorectal carcinoma (CRC), activation of the Raf/MEK/ERK signaling pathway is commonly observed. In addition, the commonly used 5FU-based chemotherapy in patients with metastatic CRC was found to enrich a subpopulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614026f49e163db04c93b9c6befa5ff7
http://hdl.handle.net/10722/203161