Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Ariel Hay"'
Autor:
Aaron Issaian, Ariel Hay, Monika Dzieciatkowska, Domenico Roberti, Silverio Perrotta, Zsuzsanna Darula, Jasmina Redzic, Micheal P. Busch, Grier P. Page, Stephen C. Rogers, Allan Doctor, Kirk C. Hansen, Elan Z. Eisenmesser, James C. Zimring, Angelo D’Alessandro
Publikováno v:
Haematologica, Vol 106, Iss 11 (2021)
Band 3 (anion exchanger 1; AE1) is the most abundant membrane protein in red blood cells, which in turn are the most abundant cells in the human body. A compelling model posits that, at high oxygen saturation, the N-terminal cytosolic domain of AE1 b
Externí odkaz:
https://doaj.org/article/62266c7a47f34d6da98e2ad9ab1f4975
Autor:
Travis Nemkov, Davide Stefanoni, Aarash Bordbar, Aaron Issaian, Bernhard O. Palsson, Larry J. Dumont, Ariel Hay, Anren Song, Yang Xia, Jasmina S. Redzic, Elan Z. Eisenmesser, James C. Zimring, Steve Kleinman, Kirk C. Hansen, Michael P. Busch, Angelo D’Alessandro, the Recipient Epidemiology and Donor Evaluation Study III Red Blood Cell–Omics (REDS-III RBC-Omics) Study
Publikováno v:
JCI Insight, Vol 6, Iss 3 (2021)
Computational models based on recent maps of the RBC proteome suggest that mature erythrocytes may harbor targets for common drugs. This prediction is relevant to RBC storage in the blood bank, in which the impact of small molecule drugs or other xen
Externí odkaz:
https://doaj.org/article/10ef3ba194d24381b742b21602b2835e
Autor:
Angelo D’Alessandro, Ariel Hay, Monika Dzieciatkowska, Benjamin C. Brown, Evan J. Morrison, Kirk C. Hansen, James C. Zimring
Publikováno v:
Haematologica, Vol 106, Iss 10 (2020)
Red blood cells (RBC) have the special challenge of a large amount of reactive oxygen species (from their substantial iron load and Fenton reactions) combined with the inability to synthesize new gene products. Considerable progress has been made in
Externí odkaz:
https://doaj.org/article/1a2b96648b4f43d4a2d49943ab7a2240
Autor:
Ariel Hay, Travis Nemkov, Fabia Gamboni, Monika Dzieciatkowska, Alicia Key, Matthew Galbraith, Kyle Bartsch, Kaiqi Sun, Yang Xia, Mars Stone, Michael P. Busch, Philip J. Norris, James C. Zimring, Angelo D’Alessandro
Publikováno v:
Blood advances, vol 7, iss 8
Blood storage promotes the rapid depletion of red blood cell (RBC) high-energy adenosine triphosphate (ATP) and 2,3-diphosphoglycerate (DPG), which are critical regulators of erythrocyte physiology and function, as well as oxygen kinetics and posttra
Autor:
Stephen C. Rogers, James C. Zimring, Allan Doctor, Jasmina S. Redzic, Monika Dzieciatkowska, Elan Z. Eisenmesser, Grier P. Page, Angelo D'Alessandro, Ariel Hay, Domenico Roberti, Zsuzsanna Darula, Aaron Issaian, Silverio Perrotta, Kirk C. Hansen, Micheal P. Busch
Publikováno v:
Haematologica
Band 3 (anion exchanger 1; AE1) is the most abundant membrane protein in red blood cells, which in turn are the most abundant cells in the human body. A compelling model posits that, at high oxygen saturation, the N-terminal cytosolic domain of AE1 b
Hypoxic storage of murine red blood cells improves energy metabolism and post-transfusion recoveries
Autor:
Ariel, Hay, Karolina, Dziewulska, Fabia, Gamboni, David, Nerguizian, Monika, Dzieciatkowska, James C, Zimring, Angelo, D'Alessandro
Publikováno v:
Blood Transfus
BACKGROUND: The Red blood cell (RBC) storage lesion results in decreased circulation and function of transfused RBCs. Elevated oxidant stress and impaired energy metabolism are a hallmark of the storage lesion in both human and murine RBCs. Although
Autor:
Ariel Hay, Lindsay M. Hannan, Heather L. Howie, Linda M. Kapp, James C. Zimring, Jacqueline N. Poston, Arijita Jash, Chomkan Usaneerungrueng
Publikováno v:
Transfusion
BACKGROUND: Platelet transfusions remain a mainstay of treatment for many patients with thrombocytopenia, but can lead to alloantibodies to Human Leukocyte Antigens (anti-HLA) resulting in inadequate responses to subsequent platelet transfusions (ref
Autor:
James C. Zimring, Angelo D'Alessandro, Evan J Morrison, Kirk C. Hansen, Monika Dzieciatkowska, Ariel Hay, Benjamin C. Brown
Publikováno v:
Haematologica. 106:2726-2739
Red blood cells have the special challenge of a large amount of reactive oxygen species (from their substantial iron load and Fenton reactions) combined with the inability to synthesize new gene products. Considerable progress has been made in elucid
Autor:
Steve Kleinman, Micaela Kalani Roy, Travis Nemkov, Lorenzo Bertolone, Michael P. Busch, Ariel Hay, Davide Stefanoni, Xiaoyun Fu, Mars Stone, Larry J. Dumont, James C. Zimring, Tamir Kanias, Angelo D'Alessandro, Evan J Morrison
Publikováno v:
Transfusion
Background Taurine is an antioxidant that is abundant in some common energy drinks. Here we hypothesized that the antioxidant activity of taurine in red blood cells (RBCs) could be leveraged to counteract storage-induced oxidant stress. Study design
Autor:
Krystalyn E. Hudson, Heather L. Howie, Ariel Hay, James C. Zimring, Angelo D'Alessandro, Steven L. Spitalnik, James D. Gorham
Publikováno v:
Transfusion
BACKGROUND Genetically modified mice are used widely to explore mechanisms in most biomedical fields-including transfusion. Concluding that a gene modification is responsible for a phenotypic change assumes no other differences between the gene-modif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9feed699918b1b52318b35ceb48ca547
https://europepmc.org/articles/PMC8627118/
https://europepmc.org/articles/PMC8627118/