Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Ariel F, Castro"'
Autor:
Mario Palma, Elizabeth Riffo, Alejandro Farias, Viviana Coliboro-Dannich, Luis Espinoza-Francine, Emilia Escalona, Roberto Amigo, José L. Gutiérrez, Roxana Pincheira, Ariel F. Castro
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-22 (2023)
Abstract Background mTORC2 is a critical regulator of cytoskeleton organization, cell proliferation, and cancer cell survival. Activated mTORC2 induces maximal activation of Akt by phosphorylation of Ser-473, but regulation of Akt activity and signal
Externí odkaz:
https://doaj.org/article/b147c3f3e6e94b8ca50919e790866969
Autor:
Elizabeth Riffo, Mario Palma, Matías I. Hepp, Diego Benítez-Riquelme, Vicente A. Torres, Ariel F. Castro, Roxana Pincheira
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
SALL2/Sall2 is a transcription factor associated with development, neuronal differentiation, and cancer. Interestingly, SALL2/Sall2 deficiency leads to failure of the optic fissure closure and neurite outgrowth, suggesting a positive role for SALL2/S
Externí odkaz:
https://doaj.org/article/64401843b61e4f34b0ec658c4fed69dd
Autor:
Carlos Farkas, Aracelly Quiroz, Claudia Alvarez, Viviana Hermosilla, Carlos F. Aylwin, Alejandro Lomniczi, Ariel F. Castro, Matias I. Hepp, Roxana Pincheira
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
The SALL2 transcription factor, an evolutionarily conserved gene through vertebrates, is involved in normal development and neuronal differentiation. In disease, SALL2 is associated with eye, kidney, and brain disorders, but mainly is related to canc
Externí odkaz:
https://doaj.org/article/6932d3d8158c4b3a8e4533cb678e9058
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
NUAK1 is an AMPK-related kinase located in the cytosol and the nucleus, whose expression associates with tumor malignancy and poor patient prognosis in several cancers. Accordingly, NUAK1 was associated with metastasis because it promotes cell migrat
Externí odkaz:
https://doaj.org/article/34dc9df67cb64b02a140eb2b5e09b602
Autor:
Cristina Pinto, Danilo B. Medinas, Francisco Fuentes-Villalobos, Jaime Maripillán, Ariel F. Castro, Agustín D. Martínez, Nelson Osses, Claudio Hetz, Juan P. Henríquez
Publikováno v:
Neurobiology of Disease, Vol 130, Iss , Pp 104497- (2019)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron death. A 20% of familial ALS cases are associated with mutations in the gene coding for superoxide dismutase 1 (SOD1). The accumulation of abnormal aggre
Externí odkaz:
https://doaj.org/article/4a0d45cd6707447e8bd3fb8034d9623c
Autor:
Viviana E. Hermosilla, Ginessa Salgado, Elizabeth Riffo, David Escobar, Matías I. Hepp, Carlos Farkas, Mario Galindo, Violeta Morín, María A. García‐Robles, Ariel F. Castro, Roxana Pincheira
Publikováno v:
Molecular Oncology, Vol 12, Iss 7, Pp 1026-1046 (2018)
SALL2 is a poorly characterized transcription factor that belongs to the Spalt‐like family involved in development. Mutations on SALL2 have been associated with ocular coloboma and cancer. In cancers, SALL2 is deregulated and is proposed as a tumor
Externí odkaz:
https://doaj.org/article/856cbb2f85544e4fa11c6cd60077a716
Autor:
Claudia Álvarez, Aracelly Quiroz, Diego Benítez-Riquelme, Elizabeth Riffo, Ariel F. Castro, Roxana Pincheira
Publikováno v:
Cancers, Vol 13, Iss 24, p 6292 (2021)
SALL proteins are a family of four conserved C2H2 zinc finger transcription factors that play critical roles in organogenesis during embryonic development. They regulate cell proliferation, survival, migration, and stemness; consequently, they are in
Externí odkaz:
https://doaj.org/article/a8427a9818314a01a58675410988447c
Autor:
Carlos, Farkas, Aracelly, Quiroz, Claudia, Alvarez, Viviana, Hermosilla, Carlos F, Aylwin, Alejandro, Lomniczi, Ariel F, Castro, Matias I, Hepp, Roxana, Pincheira
Publikováno v:
Frontiers in Genetics
The SALL2 transcription factor, an evolutionarily conserved gene through vertebrates, is involved in normal development and neuronal differentiation. In disease, SALL2 is associated with eye, kidney, and brain disorders, but mainly is related to canc
Autor:
Carlos Farkas, Carla P Martins, David Escobar, Matias I Hepp, Ariel F Castro, Gerard Evan, José L Gutiérrez, Robert Warren, David B Donner, Roxana Pincheira
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73817 (2013)
SALL2- a member of the Spalt gene family- is a poorly characterized transcription factor found deregulated in various cancers, which suggests it plays a role in the disease. We previously identified SALL2 as a novel interacting protein of neurotrophi
Externí odkaz:
https://doaj.org/article/02d66ecedf9e45539f3f30d3d29169cb
Publikováno v:
Frontiers in Oncology
Frontiers in Oncology, Vol 10 (2020)
Frontiers in Oncology, Vol 10 (2020)
Indexación: Scopus. NUAK1 is an AMPK-related kinase located in the cytosol and the nucleus, whose expression associates with tumor malignancy and poor patient prognosis in several cancers. Accordingly, NUAK1 was associated with metastasis because it