Zobrazeno 1 - 10
of 333
pro vyhledávání: '"Ariel E, Feldstein"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Externí odkaz:
https://doaj.org/article/25d68e1160a5408986fd068fa269e20b
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 3, Pp 481-497 (2024)
Background & Aims: Breast regression protein 39 (BRP39) (Chi3L1) and its human homolog YKL-40, is an established biomarker of liver fibrosis in nonalcoholic steatohepatitis (NASH) patients, but its role in NASH pathogenesis remains unclear. We recent
Externí odkaz:
https://doaj.org/article/0912e3a866a448f6a829e475f32d388a
Autor:
Geza Ambrus-Aikelin, Katsuyuki Takeda, Anthony Joetham, Milos Lazic, Davide Povero, Angelina M. Santini, Rama Pranadinata, Casey D. Johnson, Matthew D. McGeough, Federico C. Beasley, Ryan Stansfield, Christopher McBride, Lynnie Trzoss, Hal M. Hoffman, Ariel E. Feldstein, Jeffrey A. Stafford, James M. Veal, Gretchen Bain, Erwin W. Gelfand
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract The NLRP3 inflammasome is an intracellular, multiprotein complex that promotes the auto-catalytic activation of caspase-1 and the subsequent maturation and secretion of the pro-inflammatory cytokines, IL-1β and IL-18. Persistent activation
Externí odkaz:
https://doaj.org/article/a9366cea20b64379ae3b798f5d428a2d
Autor:
Christian Stoess, Yeon-Kyung Choi, Janset Onyuru, Helmut Friess, Hal M. Hoffman, Daniel Hartmann, Ariel E. Feldstein
Publikováno v:
Biomedicines, Vol 12, Iss 3, p 559 (2024)
Cell death is crucial for maintaining tissue balance and responding to diseases. However, under pathological conditions, the surge in dying cells results in an overwhelming presence of cell debris and the release of danger signals. In the liver, this
Externí odkaz:
https://doaj.org/article/9a038d8743d54482831945e945d0ad48
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
In recent years, there has been a rapid expansion in our understanding of regulated cell death, leading to the discovery of novel mechanisms that govern diverse cell death pathways. One recently discovered type of cell death is pyroptosis, initially
Externí odkaz:
https://doaj.org/article/19811f4704a640c782b43e546b76bffd
Autor:
Geza Ambrus-Aikelin, Katsuyuki Takeda, Anthony Joetham, Milos Lazic, Davide Povero, Angelina M. Santini, Rama Pranadinata, Casey D. Johnson, Matthew D. McGeough, Federico C. Beasley, Ryan Stansfield, Christopher McBride, Lynnie Trzoss, Hal M. Hoffman, Ariel E. Feldstein, Jeffrey A. Stafford, James M. Veal, Gretchen Bain, Erwin W. Gelfand
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/71601d03ca0a42d8941718d51407d3e9
Autor:
Davide Povero, Masahiko Tameda, Akiko Eguchi, Wenhua Ren, Jihoon Kim, Robert Myers, Zachary D. Goodman, Stephen A. Harrison, Arun J. Sanyal, Jaime Bosch, Lucila Ohno-Machado, Ariel E. Feldstein
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Primary sclerosing cholangitis (PSC) is an idiopathic and heterogenous cholestatic liver disease characterized by chronic inflammation and fibrosis of the biliary tree. Currently, no effective therapies are available for this condition, whos
Externí odkaz:
https://doaj.org/article/f7dd9db4292b4f9fb959aa9ca0e2edfd
Autor:
Andrea D. Kim, Sung Eun Kim, Aleksandra Leszczynska, Benedikt Kaufmann, Agustina Reca, Dong Joon Kim, Ariel E. Feldstein
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Inflammatory changes in the liver represent a key feature of non-alcoholic steatohepatitis (NASH), the progressive form of non-alcoholic fatty liver disease (NAFLD). Innate immune activation including hepatic neutrophilic infiltration acts a
Externí odkaz:
https://doaj.org/article/fed38ca200d94965a77ccb3131e9ccc6
Autor:
Nicola Santoro, Ariel E. Feldstein
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
During the last two decades, nonalcoholic fatty liver disease (NAFLD) has emerged as the most common hepatic disease in pediatrics, mainly owing to the rising prevalence of pediatric obesity. Epidemiological studies have shown that the progressive in
Externí odkaz:
https://doaj.org/article/1fdc410a5ce045acbb05793946155639
Autor:
Natalia A. Osna, Akiko Eguchi, Ariel E. Feldstein, Hidekazu Tsukamoto, Raghubendra S. Dagur, Murali Ganesan, Moses New-Aaron, Madan Kumar Arumugam, Srinivas Chava, Marcelle Ribeiro, Gyongyi Szabo, Sebastian Mueller, Shijin Wang, Cheng Chen, Steven A. Weinman, Kusum K. Kharbanda
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
This review covers some important new aspects of the alcohol-induced communications between liver parenchymal and non-parenchymal cells leading to liver injury development. The information exchange between various cell types may promote end-stage liv
Externí odkaz:
https://doaj.org/article/e69b5a4021114e218d339af1ed84fd39