Fluorescent sensors for imaging of interstitial calcium

Autor: Ariel A. Valiente-Gabioud, Inés Garteizgogeascoa Suñer, Agata Idziak, Arne Fabritius, Jérome Basquin, Julie Angibaud, U. Valentin Nägerl, Sumeet Pal Singh, Oliver Griesbeck

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

Abstract Calcium in interstitial fluids is central to systemic physiology and a crucial ion pool for entry into cells through numerous plasma membrane channels. Its study has been limited by the scarcity of methods that allow monitoring in tight inte

Externí odkaz: https://doaj.org/article/2e45164c35d54f6283163a236c70892f

Early calcium and cardiac contraction defects in a model of phospholamban R9C mutation in zebrafish

Autor: Manuel Vicente, Jussep Salgado-Almario, Ariel A. Valiente-Gabioud, Michelle M. Collins, Pierre Vincent, Beatriz Domingo, Juan Llopis

Publikováno v: Journal of molecular and cellular cardiology. 173

The phospholamban mutation Arg 9 to Cys (R9C) has been found to cause a dilated cardiomyopathy in humans and in transgenic mice, with ventricular dilation and premature death. Emerging evidence suggests that phospholamban R9C is a loss-of-function mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b301cfd42b5646bc388534a0e1726f1
https://pubmed.ncbi.nlm.nih.gov/36273660

Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies

Autor: Timo Strohäker, Ariel A. Valiente-Gabioud, Claudio O. Fernández, Pablo Peralta, Markus Zweckstetter, Filippo Favretto, Diana F. Lázaro, Annekatrin König, Caterina Masaracchia, Tiago F. Outeiro

Publikováno v: Biochimica et biophysica acta / Proteins and proteomics 1868(1), 140298 (2020). doi:10.1016/j.bbapap.2019.140298
Biochimica et Biophysica Acta-Proteins and Proteomics

The misfolding and aggregation of alpha-synuclein (aSyn) are thought to be central events in synucleinopathies. The physiological function of aSyn has been related to vesicle binding and trafficking, but the precise molecular mechanisms leading to aS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f60b044928f3b640a05400d51f26f82a
https://doi.org/10.1016/j.bbapap.2019.140298

Phthalocyanines as Molecular Scaffolds to Block Disease-Associated Protein Aggregation

Autor: Marco C. Miotto, Ariel A. Valiente-Gabioud, Maria Eugenia Chesta, Verónica A. Lombardo, Andres Binolfi, Claudio O. Fernández

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

ConspectusThe aggregation of proteins into toxic conformations plays a critical role in the development of different neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and Creutzfled-Jakob's disease (CJD). These di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37276ec69e6cf93b63275cd0a75a1a5b
https://pubmed.ncbi.nlm.nih.gov/27136297

Disruption of zinc and copper interactions with Aβ(1-40) by a non-toxic, isoniazid-derived, hydrazone: a novel biometal homeostasis restoring agent in Alzheimer's disease therapy?

Autor: Jesus Landeira-Fernandez, Daphne S. Cukierman, Nicolás A. Rey, Rachel Ann Hauser-Davis, L. V. de Freitas, Ariel A. Valiente-Gabioud, Claudio O. Fernández, Marco C. Miotto, W. S. Cruz

Publikováno v: Metallomics : integrated biometal science. 7(5)

Disruptions of biometal-Aβ(1-40) interactions by an isoniazid-derived hydrazone, INHHQ, were demonstrated via in vitro NMR titrations. The compound has adequate theoretical BBB absorption properties, assessed by in silico studies. In vivo acute toxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2468d385e1ce7860289f844f41c0a443
https://pubmed.ncbi.nlm.nih.gov/25860559