Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Ariel A, Bazzini"'
Autor:
Luciana A Castellano, Ryan J McNamara, Horacio M Pallarés, Andrea V Gamarnik, Diego E Alvarez, Ariel A Bazzini
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 10, Pp 1085-1108 (2024)
Abstract Codon optimality refers to the effect that codon composition has on messenger RNA (mRNA) stability and translation level and implies that synonymous codons are not silent from a regulatory point of view. Here, we investigated the adaptation
Externí odkaz:
https://doaj.org/article/184320cf386d41939753e9b6e637626c
Autor:
Gabriel da Silva Pescador, Danielson Baia Amaral, Joseph M. Varberg, Ying Zhang, Yan Hao, Laurence Florens, Ariel A. Bazzini
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114769- (2024)
Summary: The maternal-to-zygotic transition is crucial in embryonic development, marked by the degradation of maternally provided mRNAs and initiation of zygotic gene expression. However, the changes occurring at the protein level during this transit
Externí odkaz:
https://doaj.org/article/dabc96cdf4744e18936ee43917f3485d
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-20 (2024)
Abstract Background Early embryonic developmental programs are guided by the coordinated interplay between maternally inherited and zygotically manufactured RNAs and proteins. Although these processes happen concomitantly and affecting gene function
Externí odkaz:
https://doaj.org/article/b48d9273700c4287967fa8717806d5c6
Autor:
Michay Diez, Santiago Gerardo Medina-Muñoz, Luciana Andrea Castellano, Gabriel da Silva Pescador, Qiushuang Wu, Ariel Alejandro Bazzini
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Messenger RNA (mRNA) stability substantially impacts steady-state gene expression levels in a cell. mRNA stability is strongly affected by codon composition in a translation-dependent manner across species, through a mechanism termed codon o
Externí odkaz:
https://doaj.org/article/204b11a30bfc498588acb3f6d88435a6
Autor:
Valerie A Tornini, Liyun Miao, Ho-Joon Lee, Timothy Gerson, Sarah E Dube, Valeria Schmidt, François Kroll, Yin Tang, Katherine Du, Manik Kuchroo, Charles E Vejnar, Ariel Alejandro Bazzini, Smita Krishnaswamy, Jason Rihel, Antonio J Giraldez
Publikováno v:
eLife, Vol 12 (2023)
Thousands of long intergenic non-coding RNAs (lincRNAs) are transcribed throughout the vertebrate genome. A subset of lincRNAs enriched in developing brains have recently been found to contain cryptic open-reading frames and are speculated to encode
Externí odkaz:
https://doaj.org/article/3eb5c87de1364a89b649924c5e5d58a1
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105547- (2022)
Summary: Protein coding genes were originally identified with sequence-based definitions that included a 100-codon cutoff to avoid annotating irrelevant open reading frames. However, many active proteins contain less than 100 amino acids. Indeed, fun
Externí odkaz:
https://doaj.org/article/95fad15b1bc24b4dbe63af2fd134f94f
Autor:
Santiago Gerardo Medina-Muñoz, Gopal Kushawah, Luciana Andrea Castellano, Michay Diez, Michelle Lynn DeVore, María José Blanco Salazar, Ariel Alejandro Bazzini
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-23 (2021)
Abstract Background The regulation of messenger RNA (mRNA) stability has a profound impact on gene expression dynamics during embryogenesis. For example, in animals, maternally deposited mRNAs are degraded after fertilization to enable new developmen
Externí odkaz:
https://doaj.org/article/f74483758c7f4e47ad686076ab4d92a9
Autor:
Luis Hernandez-Huertas, Gopal Kushawah, Alejandro Diaz-Moscoso, Laura Tomas-Gallardo, Ismael Moreno-Sanchez, Gabriel da Silva Pescador, Ariel A. Bazzini, Miguel A. Moreno-Mateos
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101058- (2022)
Summary: CRISPR-Cas systems have been used to induce DNA mutagenesis for gene function discovery. However, the development of tools to eliminate RNAs provides complementary and unique approaches to disrupt gene expression. Here, we present a workflow
Externí odkaz:
https://doaj.org/article/6ccc12cb9aa841758da21124aae9cd44
Autor:
Qiushuang Wu, Santiago Gerardo Medina, Gopal Kushawah, Michelle Lynn DeVore, Luciana A Castellano, Jacqelyn M Hand, Matthew Wright, Ariel Alejandro Bazzini
Publikováno v:
eLife, Vol 8 (2019)
mRNA translation decodes nucleotide into amino acid sequences. However, translation has also been shown to affect mRNA stability depending on codon composition in model organisms, although universality of this mechanism remains unclear. Here, using t
Externí odkaz:
https://doaj.org/article/e0f8cb1a28e943fd991c55a041b0ea8b
Autor:
Qiushuang Wu, Ariel A. Bazzini
Publikováno v:
Annual Review of Biochemistry. 92
Messenger RNA (mRNA) stability and translational efficiency are two crucial aspects of the posttranscriptional process that profoundly impact protein production in a cell. While it is widely known that ribosomes produce proteins, studies during the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e99f0a6bb30444ce9692c0dd9c5b261
https://doi.org/10.1146/annurev-biochem-052621-091808
https://doi.org/10.1146/annurev-biochem-052621-091808