Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Arie S Jacoby"'
Autor:
Susana S Lopes, Xueyan Yang, Jeanette Müller, Thomas J Carney, Anthony R McAdow, Gerd-Jörg Rauch, Arie S Jacoby, Laurence D Hurst, Mariana Delfino-Machín, Pascal Haffter, Robert Geisler, Stephen L Johnson, Andrew Ward, Robert N Kelsh
Publikováno v:
PLoS Genetics, Vol 4, Iss 3, p e1000026 (2008)
A fundamental problem in developmental biology concerns how multipotent precursors choose specific fates. Neural crest cells (NCCs) are multipotent, yet the mechanisms driving specific fate choices remain incompletely understood. Sox10 is required fo
Externí odkaz:
https://doaj.org/article/f89e23d958bc4722af8d568b44265ef5
Publikováno v:
The Journal of Physiology. 583:675-684
It is established that the gut peptide galanin reduces neuronal excitability via galanin receptor subtypes GALR1 and GALR3 and increases excitability via subtype GALR2. We have previously shown that galanin potently reduces mechanosensitivity in the
Autor:
Arie S. Jacoby, Tomas Hökfelt, Pablo Brumovsky, Sergueï O. Fetissov, Tiina P. Iismaa, John Shine
Publikováno v:
Epilepsia. 44:1022-1033
Summary: Purpose: Mice carrying a deletion of the GALR1 galanin receptor have recently showed spontaneous seizure phenotype with 25% penetrance. To better understand the role of neuropeptides, which are known to undergo complex plasticity changes wit
Autor:
Zsuzsanna Wiesenfeld-Hallin, Xiao-Jun Xu, Tiina P. Iismaa, Arie S. Jacoby, Jacqueline N. Crawley, Stefan Grass
Publikováno v:
Neuroscience Letters. 345:153-156
This study was conducted to examine the excitability of the nociceptive flexor reflex and its sensitization by repetitive stimulation of C-fibers in anesthetized mice that lack the galanin-R1 receptor. Repetitive stimulation of C-fibers induced a gra
Autor:
Z. Wiesenfeld-Hallin, Jing-Xia Hao, X.-J. Xu, John Shine, Tiina P. Iismaa, Jacqueline N. Crawley, Arie S. Jacoby, Karin Hygge Blakeman
Publikováno v:
Neuroscience. 117:221-227
The neuropeptide galanin may have a role in modulation of nociception, particularly after peripheral nerve injury. The effect of galanin is mediated by at least three subtypes of receptors. In the present study, we assessed the nociceptive sensitivit
Autor:
Richard Hosking, Fiona E. Holmes, Malcolm K. Scott, Tiina P. Iismaa, Sarah Farrant, John Shine, Sally-Ann Mahoney, Arie S. Jacoby, David Wynick, Ralf Schmidt
Publikováno v:
The Journal of Neuroscience. 23:416-421
Expression of the neuropeptide galanin is markedly upregulated within the adult dorsal root ganglion (DRG) after peripheral nerve injury. We demonstrated previously that the rate of peripheral nerve regeneration is reduced in galanin knock-out mice,
Autor:
Craige C. Wrenn, John Shine, Rebecca J. Yang, Jefferson W. Kinney, Li Ma, Andrew Holmes, Jacqueline N. Crawley, Janani Vishwanath, Qian Li, Arie S. Jacoby, Tiina P. Iismaa, Caitlin E. Innerfield, Maria C. Saavedra
Publikováno v:
Neuropsychopharmacology. 28:1031-1044
The neuropeptide galanin coexists with norepinephrine and serotonin in neural systems mediating emotion. Previous findings suggested that galanin modulates anxiety-related behaviors in rodents. Three galanin receptor subtypes have been cloned; howeve
Publikováno v:
Molecular Brain Research. 107:195-200
The GALR1 galanin receptor is expressed at high levels within the central nervous system. To determine which specific actions of galanin are mediated by GALR1, we have developed mice with an insertional inactivating mutation within the gene encoding
Publikováno v:
Letters in Peptide Science. 8:139-146
The GALR1 galanin receptor is expressed at high levels within the central nervous system and is hypothesised to play a significant role in many of the central actions of galanin. To determine which specific actions of galanin are mediated by GALR1, w
Publikováno v:
Gene. 182:71-75
Using a probe obtained by PCR amplification from mouse genomic DNA, a genomic clone was isolated covering the entire mouse preprogalanin gene. The mouse gene has an exon:intron organisation very similar to that of the rat and human genes. The first e