Zobrazeno 1 - 10
of 258
pro vyhledávání: '"Arie O, Verkerk"'
Publikováno v:
Reviews in Cardiovascular Medicine, Vol 25, Iss 9, p 313 (2024)
Brugada syndrome (BrS) is an inheritable cardiac arrhythmogenic disease, associated with an increased risk of sudden cardiac death. It is most common in males around the age of 40 and the prevalence is higher in Asia than in Europe and the United Sta
Externí odkaz:
https://doaj.org/article/4e65a2cb49694cefb66aea8330f3e9d2
Autor:
Arie O. Verkerk, Ronald Wilders
Publikováno v:
Cardiogenetics, Vol 13, Iss 3, Pp 117-134 (2023)
Patients carrying the heterozygous A414G mutation in the HCN4 gene, which encodes the HCN4 protein, demonstrate moderate to severe bradycardia of the heart. Tetramers of HCN4 subunits compose the ion channels in the sinus node that carry the hyperpol
Externí odkaz:
https://doaj.org/article/ad9c5fedaf844c3e827aa0a75a2bfa26
Autor:
Arie O. Verkerk, Ronald Wilders
Publikováno v:
Reviews in Cardiovascular Medicine, Vol 25, Iss 6, p 194 (2024)
Background: Clinical and experimental data on the cardiac effects of acute hypernatremia are scarce and inconsistent. We aimed to determine and understand the effects of different levels of acute hypernatremia on the human ventricular action potentia
Externí odkaz:
https://doaj.org/article/662b32e8d3f1444cba2bcb8d360b77ee
Autor:
Giovanna Nasilli, Arie O. Verkerk, Molly O’Reilly, Loukia Yiangou, Richard P. Davis, Simona Casini, Carol Ann Remme
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1212 (2024)
A sodium current (INa) reduction occurs in the setting of many acquired and inherited conditions and is associated with cardiac conduction slowing and increased arrhythmia risks. The sodium channel blocker mexiletine has been shown to restore the tra
Externí odkaz:
https://doaj.org/article/fe7447100f724815a62f685b1a775531
Autor:
Arie O. Verkerk, Ronald Wilders
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Human-induced stem cell-derived cardiomyocytes (hiPSC-CMs) are a valuable tool for studying development, pharmacology, and (inherited) arrhythmias. Unfortunately, hiPSC-CMs are depolarized and spontaneously active, even the working cardiomyocyte subt
Externí odkaz:
https://doaj.org/article/feee9de844df42e697c94b9a90c74737
Autor:
Fernanda M Bosada, Karel van Duijvenboden, Alexandra E Giovou, Mathilde R Rivaud, Jae-Sun Uhm, Arie O Verkerk, Bastiaan J Boukens, Vincent M Christoffels
Publikováno v:
eLife, Vol 12 (2023)
Heart development and rhythm control are highly Tbx5 dosage-sensitive. TBX5 haploinsufficiency causes congenital conduction disorders, whereas increased expression levels of TBX5 in human heart samples has been associated with atrial fibrillation (AF
Externí odkaz:
https://doaj.org/article/6c9f0c237a34499487c877a31f70329b
Autor:
Jiuru Li, Alexandra Wiesinger, Lianne Fokkert, Bastiaan J. Boukens, Arie O. Verkerk, Vincent M. Christoffels, Gerard J.J. Boink, Harsha D. Devalla
Publikováno v:
Journal of Tissue Engineering, Vol 13 (2022)
Paucity of physiologically relevant cardiac models has limited the widespread application of human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes in drug development. Here, we performed comprehensive characterization of hiPSC-derived ca
Externí odkaz:
https://doaj.org/article/d11b5bd0afdc45c299819e90950e9bde
Autor:
Alexandra Wiesinger, Jiuru Li, Lianne Fokkert, Priscilla Bakker, Arie O Verkerk, Vincent M Christoffels, Gerard JJ Boink, Harsha D Devalla
Publikováno v:
eLife, Vol 11 (2022)
Each heartbeat is triggered by the sinoatrial node (SAN), the primary pacemaker of the heart. Studies in animal models have revealed that pacemaker cells share a common progenitor with the (pro)epicardium, and that the pacemaker cardiomyocytes furthe
Externí odkaz:
https://doaj.org/article/17bc9b7e4c9f4f619baccc66fec6fcc9
Autor:
Arie O. Verkerk, Ronald Wilders
Publikováno v:
Biomedicines, Vol 11, Iss 9, p 2447 (2023)
These days, in vitro functional analysis of gene variants is becoming increasingly important for risk stratification of cardiac ion channelopathies. So far, such risk stratification has been applied to SCN5A, KCNQ1, and KCNH2 gene variants associated
Externí odkaz:
https://doaj.org/article/a46eddc9065c4f76878a46b788bbc522
Autor:
Gerard A. Marchal, Maaike van Putten, Arie O. Verkerk, Simona Casini, Kayleigh Putker, Shirley C. M. van Amersfoorth, Annemieke Aartsma-Rus, Elisabeth M. Lodder, Carol Ann Remme
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disorder caused by loss of dystrophin. This lack also affects cardiac structure and function, and cardiovascular complications are a major cause of death in DMD. Newly develope
Externí odkaz:
https://doaj.org/article/e66d62ff25c047aab32a8e28fe2c4a19