Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Arie J. Hoogendijk"'
Autor:
Eva R. Smit, Diana Muñoz Sandoval, Iris C. Kreft, Pieter F. van der Meer, Carmen van der Zwaan, Jan Voorberg, Paula F. Ypma, Arie J. Hoogendijk, Jean-Louis Kerkhoffs, Maartje van den Biggelaar
Publikováno v:
Translational Medicine Communications, Vol 9, Iss 1, Pp 1-12 (2024)
Abstract Background Bone marrow aplasia is a common feature in acute myeloid leukemia (AML) patients during their remission induction treatment, and is associated with potential complications such as bleeding, infection and anemia. Frequent platelet
Externí odkaz:
https://doaj.org/article/aba982d46f2c4cabb3f670f869e6df7c
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Blood vessel endothelial cells (EC) display heterogeneity across vascular beds, which is anticipated to drive site-specific vascular pathology. This heterogeneity is assessed using transcriptomics in vivo, and functional assays in vitro, but
Externí odkaz:
https://doaj.org/article/06cc2221f0e8455d8930e79cea480693
Autor:
Iris C. Kreft, Annemarie van deGeer, Eva R. Smit, Carmen van derZwaan, Floris P. J. vanAlphen, Alexander B. Meijer, Erfan Nur, Arie J. Hoogendijk, Taco W. Kuijpers, Maartje van denBiggelaar
Publikováno v:
Cancer Reports, Vol 7, Iss 10, Pp n/a-n/a (2024)
ABSTRACT Background Acute myeloid leukemia (AML) is a heterogenous and complex blood cancer requiring aggressive treatment. Early identification and prediction of the complications following treatment is vital for effective disease management. Aims W
Externí odkaz:
https://doaj.org/article/5ed35715af38478382e4c0057ec01d39
Autor:
Erik H. A. Michels, Osoul Chouchane, Justin de Brabander, Alex F. de Vos, Daniël R. Faber, Renée A. Douma, Eva R. Smit, W. Joost Wiersinga, Maartje van den Biggelaar, Tom van der Poll, Arie J. Hoogendijk
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionNeutrophils play a dichotomous role in community-acquired pneumonia (CAP), providing protection and potentially causing damage. Existing research on neutrophil function in CAP relies on animal studies, leaving a gap in patient-centered in
Externí odkaz:
https://doaj.org/article/82da1f3eae65400f9cacb7010bc64673
Autor:
Marthe Minderman, Hildo Lantermans, Carmen van der Zwaan, Arie J. Hoogendijk, Maartje van den Biggelaar, Marie José Kersten, Marcel Spaargaren, Steven T. Pals
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract MYD88 is the key signaling adaptor-protein for Toll-like and interleukin-1 receptors. A somatic L265P mutation within the Toll/interleukin-1 receptor (TIR) domain of MYD88 is found in 90% of Waldenström macroglobulinemia cases and in a sign
Externí odkaz:
https://doaj.org/article/6567367aa7a8454c9dcdd166992c7d1a
Autor:
Panagiota Bouti, Bart J. A. M. Klein, Paul J. H. Verkuijlen, Karin Schornagel, Floris P. J. van Alphen, Kees-Karel H. Taris, Maartje van den Biggelaar, Arie J. Hoogendijk, Robin van Bruggen, Taco W. Kuijpers, Hanke L. Matlung
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundThe importance of CD11b/CD18 expression in neutrophil effector functions is well known. Beyond KINDLIN3 and TALIN1, which are involved in the induction of the high-affinity binding CD11b/CD18 conformation, the signaling pathways that orches
Externí odkaz:
https://doaj.org/article/53bd94c6190c4bc09c41a6251de19372
Autor:
Stijn A. Groten, Eva R. Smit, Esmée F. J. Janssen, Bart L. van den Eshof, Floris P. J. van Alphen, Carmen van der Zwaan, Alexander B. Meijer, Arie J. Hoogendijk, Maartje van den Biggelaar
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract Vascular endothelial cells (ECs) form a dynamic interface between blood and tissue and play a crucial role in the progression of vascular inflammation. Here, we aim to dissect the system-wide molecular mechanisms of inflammatory endothelial-
Externí odkaz:
https://doaj.org/article/14e6d1dfbe254a5bb29f4f4bd6c78adf
Autor:
Hina N. Khan, Xanthe Brands, Simona Aufiero, Arie J. Hoogendijk, Augustijn M. Klarenbeek, Tjitske S. R. van Engelen, Bastiaan W. Haak, Lonneke A. van Vught, Janneke Horn, Marcus J. Schultz, Aeilko H. Zwinderman, Tom van der Poll, Brendon P. Scicluna
Publikováno v:
Critical Care, Vol 24, Iss 1, Pp 1-12 (2020)
Abstract Background Dysregulation of the host immune response is a pathognomonic feature of sepsis. Abnormal physiological conditions are understood to shift efficient linear splicing of protein-coding RNA towards non-canonical splicing, characterize
Externí odkaz:
https://doaj.org/article/513972d7beef4ee78770d62e5c16ca46
Autor:
Marije Kat, Ellie Karampini, Arie J. Hoogendijk, Petra E. Bürgisser, Aat A. Mulder, Floris P.J. van Alphen, Jenny Olins, Dirk Geerts, Maartje van den Biggelaar, Coert Margadant, Jan Voorberg, Ruben Bierings
Publikováno v:
Haematologica, Vol 107, Iss 8 (2022)
Von Willebrand factor (VWF) is a multimeric hemostatic protein primarily synthesized in endothelial cells. VWF is stored in endothelial storage organelles, the Weibel-Palade bodies (WPB), whose biogenesis strongly depends on VWF anterograde trafficki
Externí odkaz:
https://doaj.org/article/3f3b76fdbfd641bd82110fcb6a81d836
Autor:
Xanthe Brands, Fabrice Uhel, Lonneke A. van Vught, Maryse A. Wiewel, Arie J. Hoogendijk, René Lutter, Marcus J. Schultz, Brendon P. Scicluna, Tom van der Poll
Publikováno v:
PLoS ONE, Vol 17, Iss 7 (2022)
Objective Patients admitted to the Intensive Care Unit (ICU) oftentimes show immunological signs of immune suppression. Consequently, immune stimulatory agents have been proposed as an adjunctive therapy approach in the ICU. The objective of this stu
Externí odkaz:
https://doaj.org/article/766c335086a943f5bf7157edd701cb96