Evidence for sex-specific intramuscular changes associated to physical weakness in adults older than 75 years

Autor: Jelle C. B. C. de Jong, Lars Verschuren, Martien P. M. Caspers, Marjanne D. van der Hoek, Feike R. van der Leij, Robert Kleemann, Anita M. van den Hoek, Arie G. Nieuwenhuizen, Jaap Keijer

Publikováno v: Biology of Sex Differences, Vol 14, Iss 1, Pp 1-14 (2023)

Abstract Background Physical weakness is a key component of frailty, and is highly prevalent in older adults. While females have a higher prevalence and earlier onset, sex differences in the development of frailty-related physical weakness are hardly

Externí odkaz: https://doaj.org/article/8da9ab685829430a8ea35e5ca7a93789

Muscle mitochondrial capacity in high‐ and low‐fitness females using near‐infrared spectroscopy

Autor: Bart Lagerwaard, Joëlle J. E. Janssen, Iris Cuijpers, Jaap Keijer, Vincent C. J. deBoer, Arie G. Nieuwenhuizen

Publikováno v: Physiological Reports, Vol 9, Iss 9, Pp n/a-n/a (2021)

Abstract The recovery of muscle oxygen consumption (mV˙O2) after exercise measured using near‐infrared spectroscopy (NIRS) provides a measure of skeletal muscle mitochondrial capacity. Nevertheless, due to sex differences in factors that can influ

Externí odkaz: https://doaj.org/article/0c16dba2daba416ca31735ab6928670b

Sex differences in skeletal muscle-aging trajectory : same processes, but with a different ranking

Autor: Jelle C.B.C. de Jong, Brecht J. Attema, Marjanne D. van der Hoek, Lars Verschuren, Martien P.M. Caspers, Robert Kleemann, Feike R. van der Leij, Anita M. van den Hoek, Arie G. Nieuwenhuizen, Jaap Keijer

Publikováno v: GeroScience
GeroScience, 2023, 1-20. Springer
GeroScience (2023)

Sex differences in muscle aging are poorly understood, but could be crucial for the optimization of sarcopenia-related interventions. To gain insight into potential sex differences in muscle aging, we recruited young (23 ± 2 years, 13 males and 13 f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44db30c78da8a9510047b02022c1b738
https://research.wur.nl/en/publications/sex-differences-in-skeletal-muscle-aging-trajectory-same-processe

Intramuscular short-chain acylcarnitines in elderly people are decreased in (pre-)frail females, but not in males

Autor: Veronika Paluchova, Robert Kleemann, Ondřej Kuda, Lars Verschuren, Jaap Keijer, Marjanne D. van der Hoek, Anita M. van den Hoek, Paul G. Bos, Nic J. G. M. Veeger, Feike R. van der Leij, Arie G. Nieuwenhuizen

Publikováno v: FASEB Journal, 34(9), 11658-11671
FASEB Journal 34 (2020) 9
The FASEB Journal., 34, 11658-11671. New York: Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology

This study tested the hypothesis that in human aging, a decreased intramuscular acylcarnitine status is associated with (pre-)frailty, reduced physical performance, and altered mitochondrial function. We used a cross-sectional study design with well-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bcc028a192d1a6c80394d0dfe91f2bb
https://doi.org/10.1096/fj.202000493r

Single and Joined Behaviour of Circulating Biomarkers and Metabolic Parameters in High-Fit and Low-Fit Healthy Females

Autor: Joëlle J. E. Janssen, Bart Lagerwaard, Arie G. Nieuwenhuizen, Xavier Escoté, Núria Canela, Josep M. del Bas, Vincent C. J. de Boer, Jaap Keijer

Publikováno v: International Journal of Molecular Sciences 24 (2023) 4
International Journal of Molecular Sciences, 24(4)
International Journal of Molecular Sciences
Volume 24
Issue 4
Pages: 4202

Biomarkers are important in the assessment of health and disease, but are poorly studied in still healthy individuals with a (potential) different risk for metabolic disease. This study investigated, first, how single biomarkers and metabolic paramet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b1cf76fa4d498bbfccb7f3e38f5d38
https://doi.org/10.3390/ijms24044202