Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Arie Dagan"'
Autor:
Chanchal Thomas Mannully, Reut Bruck-Haimson, Anish Zacharia, Paul Orih, Alaa Shehadeh, Daniel Saidemberg, Natalya M. Kogan, Sivan Alfandary, Raphael Serruya, Arie Dagan, Isabelle Petit, Arieh Moussaieff
Publikováno v:
Cell Death and Disease, Vol 13, Iss 12, Pp 1-11 (2022)
Abstract Stem cells are defined by their ability to self-renew and differentiate, both shown in multiple studies to be regulated by metabolic processes. To decipher metabolic signatures of self-renewal in blastocyst-derived stem cells, we compared ea
Externí odkaz:
https://doaj.org/article/1550bbce4530401f9f2e8726ddd2b069
Publikováno v:
Journal of Fungi, Vol 9, Iss 2, p 227 (2023)
Dematiaceous fungi are pigmented molds with a high content of melanin in their cell walls that can cause fatal infections in immunocompromised hosts. Direct microscopy is the main method for the rapid diagnosis of dematiaceous fungi in clinical speci
Externí odkaz:
https://doaj.org/article/7ce66f59156b4096b0f1c1b2ee3ae1f0
Publikováno v:
Materials, Vol 14, Iss 13, p 3525 (2021)
Calcium carbonate (CaCO3) is one of the most abundant substances on earth and has a large array of industrial applications. Considerable research has been conducted in an effort to synthesize calcium carbonate microparticles with controllable and spe
Externí odkaz:
https://doaj.org/article/247ca25fe00b427f8d98538eed87cbfc
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 11, Pp 2315-2324 (2005)
We report the synthesis and characterization of a novel thiourea derivative of sphingomyelin (AD2765). In vitro assays using pure enzyme and/or cell extracts revealed that this compound inhibited the hydrolysis of BODIPY-conjugated or 14C-labeled sph
Externí odkaz:
https://doaj.org/article/0e3c9696d4ce48b6a8816460f180b6ee
Publikováno v:
Drug delivery and translational research.
Methionine aminopeptidase 2 (MetAp2) inhibition has been recognized as a promising approach for suppressing angiogenesis and cancer progression. Small molecule fumagillol derivatives with adamantane side groups were synthesized and evaluated for MetA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a7c8b94bb1bdb32711c91f066e649e
https://pubmed.ncbi.nlm.nih.gov/35637333
https://pubmed.ncbi.nlm.nih.gov/35637333
Autor:
Arie Dagan, Jing Song
Ceramide metabolism is a potential target for anti-cancer therapy. Studies show that chemotherapeutic agents can induce apoptosis and it is mediated by ceramide. Synthesized sphingolipid analogs can induce cell death in human lymphocytes and leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e40dab5e090e894807f56572bc0e3da1
https://doi.org/10.1101/2021.10.01.462804
https://doi.org/10.1101/2021.10.01.462804
Publikováno v:
Nanomedicine : nanotechnology, biology, and medicine. 36
Drug penetration through the skin is significant for both transdermal and dermal delivery. One mechanism that has attracted attention over the last two decades is the transport pathway of nanoparticles via hair follicle, through the epidermis, direct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b90b56bebd6fd2ef3e5cc75a4ab2625a
https://pubmed.ncbi.nlm.nih.gov/34171468
https://pubmed.ncbi.nlm.nih.gov/34171468
Autor:
Reuven Or, Hugh Rosen, Jing Song, Osnat Almogi-Hazan, Zhanna Yakhtin, Arie Dagan, Sean Riley, Shimon Gatt
Publikováno v:
Oncotarget
Sphingolipid derivatives play key roles in immune cell migration and function. Synthetic sphingolipid analogues are used as therapeutics to intervene various inflammatory and malignant conditions. We hypothesize that different analogs have different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b1de18343d6a573abf69581b1424b6
http://europepmc.org/articles/PMC5581131
http://europepmc.org/articles/PMC5581131
Autor:
Meital Ben-David-Naim, Etty Grad, Gil Aizik, Arie Dagan, Gershon Golomb, Alisa Morss Clyne, Mirjam M. Nordling-David, Zvi Granot
Publikováno v:
Cancers
Volume 11
Issue 4
Cancers, Vol 11, Iss 4, p 442 (2019)
Volume 11
Issue 4
Cancers, Vol 11, Iss 4, p 442 (2019)
Non-viral, polymeric-based, siRNA nanoparticles (NPs) have been proposed as promising gene delivery systems. Encapsulating siRNA in targeted NPs could confer improved biological stability, extended half-life, enhanced permeability, effective tumor ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8f7b8f21eae2fed52c19deefa59a6b
https://pubmed.ncbi.nlm.nih.gov/30934857
https://pubmed.ncbi.nlm.nih.gov/30934857
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:507-512
A series of novel 3-hydroxy vinylboronates which share structural similarities with sphingolipids were synthesized and tested in vitro and in vivo as anticancer agents. The molecules reduced cancer cell survival in vitro by influencing their sphingol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb08d255f54b0e9a1ce6e287e7d6e062
https://doi.org/10.1016/j.bmcl.2012.11.028
https://doi.org/10.1016/j.bmcl.2012.11.028