Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Aric N Rogers"'
Autor:
Clemens Heissenberger, Jarod A Rollins, Teresa L Krammer, Fabian Nagelreiter, Isabella Stocker, Ludivine Wacheul, Anton Shpylovyi, Koray Tav, Santina Snow, Johannes Grillari, Aric N Rogers, Denis L J Lafontaine, Markus Schosserer
Publikováno v:
eLife, Vol 9 (2020)
Our knowledge about the repertoire of ribosomal RNA modifications and the enzymes responsible for installing them is constantly expanding. Previously, we reported that NSUN-5 is responsible for depositing m5C at position C2381 on the 26S rRNA in Caen
Externí odkaz:
https://doaj.org/article/1cc8244758b2472cba30eb6282f5295a
Autor:
Harper S. Kim, Danitra J. Parker, Madison M. Hardiman, Erin Munkácsy, Nisi Jiang, Aric N. Rogers, Yidong Bai, Colin Brent, James A. Mobley, Steven N. Austad, Andrew M. Pickering
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Protein translation (PT) declines with age in invertebrates, rodents, and humans. It has been assumed that elevated PT at young ages is beneficial to health and PT ends up dropping as a passive byproduct of aging. In Drosophila, we show that
Externí odkaz:
https://doaj.org/article/9b7c7453c2704f3090c9123524769e52
Autor:
Santina Snow, Dilawar Ahmad Mir, Zhengxin Ma, Jordan Horrocks, Matthew Cox, Marissa Ruzga, Hussein Sayed, Aric N. Rogers
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 7, p 264 (2024)
Background: The ability to maintain muscle function decreases with age and loss of proteostatic function. Diet, drugs, and genetic interventions that restrict nutrients or nutrient signaling help preserve long-term muscle function and slow age-relate
Externí odkaz:
https://doaj.org/article/f864b4c0b9fc4a8d924bcc508b367fd0
Publikováno v:
Biomedicines, Vol 12, Iss 5, p 1110 (2024)
The evolutionarily conserved nonsense-mediated mRNA decay (NMD) pathway is a quality control mechanism that degrades aberrant mRNA containing one or more premature termination codons (PTCs). Recent discoveries indicate that NMD also differentially re
Externí odkaz:
https://doaj.org/article/9351dc646eed4b9e8cf052d8b1443d49
Autor:
Zhengxin Ma, Jordan Horrocks, Dilawar A. Mir, Matthew Cox, Marissa Ruzga, Jarod Rollins, Aric N. Rogers
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
The highly conserved integrated stress response (ISR) reduces and redirects mRNA translation in response to certain forms of stress and nutrient limitation. It is activated when kinases phosphorylate a key residue in the alpha subunit of eukaryotic t
Externí odkaz:
https://doaj.org/article/63e695f2fdb74d0eaa8066bf2805c6c5
Autor:
Amber C. Howard, Dilawar Mir, Santina Snow, Jordan Horrocks, Hussein Sayed, Zhengxin Ma, Aric N. Rogers
Publikováno v:
Frontiers in Aging, Vol 2 (2021)
As the most energetically expensive cellular process, translation must be finely tuned to environmental conditions. Dietary restriction attenuates signaling through the nutrient sensing mTOR pathway, which reduces translation and redirects resources
Externí odkaz:
https://doaj.org/article/a7e04c1616b2458f9d142367a2fca300
Autor:
Frauke Adamla, Jarod Rollings, Matthew Newsom, Santina Snow, Markus Schosserer, Clemens Heissenberger, Jordan Horrocks, Aric N. Rogers, Zoya Ignatova
Publikováno v:
Cellular Physiology and Biochemistry, Vol 52, Iss 5, Pp 970-983 (2019)
Externí odkaz:
https://doaj.org/article/0fb8442df33c4cbdabd03db24b7a9df3
Autor:
Anita V. Kumar, Taewook Kang, Tara G. Thakurta, Celeste Ng, Aric N. Rogers, Martin R. Larsen, Louis R. Lapierre
Publikováno v:
Kumar, A V, Kang, T, Thakurta, T G, Ng, C, Rogers, A N, Larsen, M R & Lapierre, L R 2022, ' Exportin 1 modulates life span by regulating nucleolar dynamics via the autophagy protein LGG-1/GABARAP ', Science Advances, vol. 8, no. 13, eabj1604 . https://doi.org/10.1126/sciadv.abj1604
Altered nucleolar and ribosomal dynamics are key hallmarks of aging, but their regulation remains unclear. Building on the knowledge that the conserved nuclear export receptor Exportin 1 (XPO-1/XPO1) modulates proteostasis and life span, we systemati
Autor:
Isabella Stocker, Teresa L Krammer, Clemens Heissenberger, Anton Shpylovyi, Ludivine Wacheul, Santina Snow, Koray Tav, Markus Schosserer, Johannes Grillari, Denis L. J. Lafontaine, Aric N. Rogers, Jarod Rollins, Fabian Nagelreiter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76272e6d1ccdfc818e61968ab31a3faf
https://doi.org/10.7554/elife.56205.sa2
https://doi.org/10.7554/elife.56205.sa2
Autor:
Isabella Stocker, Johannes Grillari, Jarod Rollins, Santina Snow, Clemens Heissenberger, Denis L. J. Lafontaine, Fabian Nagelreiter, Teresa L Krammer, Anton Shpylovyi, Aric N. Rogers, Markus Schosserer, Ludivine Wacheul
Our knowledge about the repertoire of ribosomal RNA modifications and the enzymes responsible for installing them is constantly expanding. Previously, we reported that NSUN-5 is responsible for depositing m5C at position C2381 on the 26S rRNA in Caen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f32d1f3d58fb25ae564c4835b59fd12