Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Arianna Tolone"'
Autor:
Arianna Tolone, Wadood Haq, Alexandra Fachinger, Akanksha Roy, Sandeep Kesh, Andreas Rentsch, Sophie Wucherpfennig, Yu Zhu, John Groten, Frank Schwede, Tushar Tomar, Friedrich W. Herberg, Vasilica Nache, François Paquet-Durand
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 20, p 15277 (2023)
Hereditary retinal degeneration (RD) is often associated with excessive cGMP signalling in photoreceptors. Previous research has shown that inhibition of cGMP-dependent protein kinase G (PKG) can reduce photoreceptor loss in two different RD animal m
Externí odkaz:
https://doaj.org/article/dc74ee6550dc424882f3774d782d51df
Autor:
Akanksha Roy, Arianna Tolone, Riet Hilhorst, John Groten, Tushar Tomar, François Paquet-Durand
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-12 (2022)
Abstract Inherited retinal diseases (IRDs) are a group of neurodegenerative disorders that lead to photoreceptor cell death and eventually blindness. IRDs are characterised by a high genetic heterogeneity, making it imperative to design mutation-inde
Externí odkaz:
https://doaj.org/article/78efcf27405940b8a50d8b999e7e43f9
Autor:
Yu Zhu, Bowen Cao, Arianna Tolone, Jie Yan, Gustav Christensen, Blanca Arango-Gonzalez, Marius Ueffing, François Paquet-Durand
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Therapy development for neurodegenerative diseases of the retina constitutes a major unmet medical need, and this may be particularly relevant for inherited diseases of the retina, which are largely untreatable to this day. Therapy development necess
Externí odkaz:
https://doaj.org/article/9e4ecf6b0271404aa2dd8540bbb1e0a1
Autor:
Philine Marchetta, Dorit Möhrle, Philipp Eckert, Katrin Reimann, Steffen Wolter, Arianna Tolone, Isabelle Lang, Markus Wolters, Robert Feil, Jutta Engel, François Paquet-Durand, Michaela Kuhn, Marlies Knipper, Lukas Rüttiger
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
In the inner ear, cyclic guanosine monophosphate (cGMP) signaling has been described as facilitating otoprotection, which was previously observed through elevated cGMP levels achieved by phosphodiesterase 5 inhibition. However, to date, the upstream
Externí odkaz:
https://doaj.org/article/46f38ac8392c45f9b2fa65806ff6a2d1
Publikováno v:
Genes, Vol 10, Iss 6, p 453 (2019)
Photoreceptor physiology and pathophysiology is intricately linked to guanosine-3’,5’-cyclic monophosphate (cGMP)-signaling. Here, we discuss the importance of cGMP-signaling for the pathogenesis of hereditary retinal degeneration. Excessive accu
Externí odkaz:
https://doaj.org/article/b6f1775cc91e47edaac2fe7d9efdfefb
Autor:
Michel Rasmussen, Arianna Tolone, Francois Paquet‐Durand, Charlotte Welinder, Frank Schwede, Per Ekström
Publikováno v:
Journal of Comparative Neurology. 531:935-951
Autor:
Jie Yan, Yiyi Chen, Gustav Christensen, François Paquet-Durand, Soumaya Belhadj, Arianna Tolone, Soumyaparna Das
Publikováno v:
Pflugers Archiv
The second messengers, cGMP and Ca2+, have both been implicated in retinal degeneration; however, it is still unclear which of the two is most relevant for photoreceptor cell death. This problem is exacerbated by the close connections and crosstalk b
Autor:
Arianna Tolone, Frank Schwede, François Paquet-Durand, Alexandra Fachinger, Wadood Haq, Friedrich W. Herberg, Andreas Rentsch
Hereditary retinal degeneration (RD) is often associated with excessive cGMP-signaling in photoreceptors. Previous research has shown that inhibition of cGMP-dependent protein kinase G (PKG) can slow down the loss of photoreceptors in different RD an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16d215dd9c4ca5b06ed409ab1e20f03c
https://doi.org/10.1101/2021.08.05.455191
https://doi.org/10.1101/2021.08.05.455191
Autor:
Arianna, Tolone, Merve, Sen, Yiyi, Chen, Marius, Ueffing, Blanca, Arango-Gonzalez, François, Paquet-Durand
Publikováno v:
Cold Spring Harbor Perspectives in Medicine. :a041310
The precise processes causing photoreceptor cell death in retinal degeneration (RD) are still largely unknown but are likely to follow a variety of degenerative mechanisms. While different genetic insults can trigger distinct molecular pathways, even
Autor:
Soumyaparna Das, Soumaya Belhadj, Gustav Christensen, François Paquet-Durand, Arianna Tolone, Yiyi Chen
Publikováno v:
Journal of Visualized Experiments.
In ophthalmic research, there is a strong need for in vitro models of the neuroretina. Here, we present a detailed protocol for organotypic culturing of the mouse neuroretina with intact retinal pigment epithelium (RPE). Depending on the research que