Výsledky vyhledávání - "Arianna Tocchetti"

Akademický článek

Understanding the Mechanism of Action of NAI-112, a Lanthipeptide with Potent Antinociceptive Activity

Autor: Arianna Tocchetti, Marianna Iorio, Zeeshan Hamid, Andrea Armirotti, Angelo Reggiani, Stefano Donadio

Publikováno v: Molecules, Vol 26, Iss 22, p 6764 (2021)

NAI-112, a glycosylated, labionine-containing lanthipeptide with weak antibacterial activity, has demonstrated analgesic activity in relevant mouse models of nociceptive and neuropathic pain. However, the mechanism(s) through which NAI-112 exerts its

Externí odkaz: https://doaj.org/article/9f0b0a372125406d8ba46ba0a7a89b68

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Akademický článek

Novel Polyethers from Screening Actinoallomurus spp.

Autor: Marianna Iorio, Arianna Tocchetti, Joao Carlos Santos Cruz, Giancarlo Del Gatto, Cristina Brunati, Sonia Ilaria Maffioli, Margherita Sosio, Stefano Donadio

Publikováno v: Antibiotics, Vol 7, Iss 2, p 47 (2018)

In screening for novel antibiotics, an attractive element of novelty can be represented by screening previously underexplored groups of microorganisms. We report the results of screening 200 strains belonging to the actinobacterial genus Actinoallomu

Externí odkaz: https://doaj.org/article/85195c37ead6440699c5ff9bca65052e

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Akademický článek

A Genomic, Transcriptomic and Proteomic Look at the GE2270 Producer Planobispora rosea, an Uncommon Actinomycete.

Autor: Arianna Tocchetti, Roberta Bordoni, Giuseppe Gallo, Luca Petiti, Giorgio Corti, Silke Alt, Joao C S Cruz, Anna Maria Salzano, Andrea Scaloni, Anna Maria Puglia, Gianluca De Bellis, Clelia Peano, Stefano Donadio, Margherita Sosio

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0133705 (2015)

We report the genome sequence of Planobispora rosea ATCC 53733, a mycelium-forming soil-dweller belonging to one of the lesser studied genera of Actinobacteria and producing the thiopeptide GE2270. The P. rosea genome presents considerable convergenc

Externí odkaz: https://doaj.org/article/c70781536b33424ca81d8a7674fd745c

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Akademický článek

Heterologous expression of the thiopeptide antibiotic GE2270 from Planobispora rosea ATCC 53733 in Streptomyces coelicolor requires deletion of ribosomal genes from the expression construct.

Autor: Katrin Flinspach, Claudia Kapitzke, Arianna Tocchetti, Margherita Sosio, Alexander K Apel

Publikováno v: PLoS ONE, Vol 9, Iss 3, p e90499 (2014)

GE2270 is a thiopeptide antibiotic generated by extensive posttranslational modifications of a ribosomally generated precursor peptide. Thiopeptides are especially active against Gram-positive bacteria, including methicillin resistant Staphylococcus

Externí odkaz: https://doaj.org/article/572910af41d147d0adcaa4d341a6d106

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Akademický článek

Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice.

Publikováno v: PLoS ONE, Vol 5, Iss 3, p e9468 (2010)

BACKGROUND: In a variety of organisms, including mammals, caloric restriction improves metabolic status and lowers the incidence of chronic-degenerative diseases, ultimately leading to increased lifespan. METHODOLOGY/PRINCIPAL FINDINGS: Here we show

Externí odkaz: https://doaj.org/article/2a746982e64d423bb314f9a07839f706

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Allopeptimicins: unique antibacterial metabolites generated by hybrid PKS-NRPS, with original self-defense mechanism in Actinoallomurus

Autor: Marianna Iorio, Andrea Gentile, Cristina Brunati, Arianna Tocchetti, Paolo Landini, Sonia Ilaria Maffioli, Stefano Donadio, Margherita Sosio

Publikováno v: RSC Advances. 12:16640-16655

In the search for structurally novel metabolites with antibacterial activity, innovative approaches must be implemented to increase the probability of discovering novel chemistry from microbial sources. Here we report on the application of metabolomi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7df553c10f1e1d7bd3e7d51d80b79a
https://doi.org/10.1039/d2ra02094g

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Challenges and advances in genetic manipulation of filamentous actinomycetes – the remarkable producers of specialized metabolites

Autor: Arianna Tocchetti, Margherita Sosio, Ewa M. Musiol-Kroll, Evi Stegmann

Publikováno v: Natural Product Reports. 36:1351-1369

Covering: up to February 2019Actinomycetes are Gram positive bacteria of the phylum Actinobacteria. These organisms are one of the most important sources of structurally diverse, clinically used antibiotics and other valuable bioactive products, as w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8c6374cfb0ca1913c208ae0783ea46c
https://doi.org/10.1039/c9np00029a

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Effective approaches to discover new microbial metabolites in a large strain library

Autor: Guadalupe S. Zarazúa, Marianna Iorio, Arianna Tocchetti, Mitja M Zdouc, Margherita Sosio, Cristina Brunati, Matteo Simone, Stefania Serina, Kristiina Vind, Max Crüsemann, Paolo Monciardini, Stefano Donadio, Sonia I. Maffioli

Publikováno v: Journal of Industrial Microbiology and Biotechnology
Journal of Industrial Microbiology and Biotechnology, 48(3-4)
Journal of Industrial Microbiology and Biotechnology 48 (2021) 3-4

Natural products have provided many molecules to treat and prevent illnesses in humans, animals and plants. While only a small fraction of the existing microbial diversity has been explored for bioactive metabolites, tens of thousands of molecules ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e41e7f3c4b8d748c36a078b7fa82197
https://doi.org/10.1093/jimb/kuab017

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A Two-Component regulatory system with opposite effects on glycopeptide antibiotic biosynthesis and resistance

Autor: Rosa Alduina, Margherita Sosio, Stefano Donadio, Patrizia Cancemi, Clelia Ferraro, Salvatore Costa, Arianna Tocchetti

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports

The glycopeptide A40926, produced by the actinomycete Nonomuraea gerenzanensis, is the precursor of dalbavancin, a second-generation glycopeptide antibiotic approved for clinical use in the USA and Europe in 2014 and 2015, respectively. The final pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19f57ddad0cfb21ba90b52955a973afa
https://doi.org/10.1038/s41598-020-63257-4

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Large inserts for big data: artificial chromosomes in the genomic era

Autor: Arianna Tocchetti, Margherita Sosio, Stefano Donadio

Publikováno v: FEMS Microbiology Letters. 365

The exponential increase in available microbial genome sequences coupled with predictive bioinformatic tools is underscoring the genetic capacity of bacteria to produce an unexpected large number of specialized bioactive compounds. Since most of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6d479552a3e7e6695e654dab62d1fef
https://doi.org/10.1093/femsle/fny064

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