Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Arianna Novati"'
Publikováno v:
Neurobiology of Disease, Vol 171, Iss , Pp 105725- (2022)
While Huntington disease (HD) is caused solely by a polyglutamine expansion in the huntingtin gene, environmental factors can influence HD onset and progression. Here, we review studies linking environment and HD in both humans and animal models. In
Externí odkaz:
https://doaj.org/article/5205de388e9c45b399ec045485cfd7b8
Autor:
Libo Yu-Taeger, Arianna Novati, Jonasz Jeremiasz Weber, Elisabeth Singer-Mikosch, Ann-Sophie Pabst, Fubo Cheng, Carsten Saft, Jennifer Koenig, Gisa Ellrichmann, Taneli Heikkinen, Mahmoud A. Pouladi, Olaf Riess, Huu Phuc Nguyen
Publikováno v:
Cells, Vol 11, Iss 23, p 3779 (2022)
Body weight (BW) loss and reduced body mass index (BMI) are the most common peripheral alterations in Huntington disease (HD) and have been found in HD mutation carriers and HD animal models before the manifestation of neurological symptoms. This sug
Externí odkaz:
https://doaj.org/article/182d9543377f43cc8144fbbfc702c74e
Autor:
Giuseppe Manfré, Arianna Novati, Ilaria Faccini, Andrea C Rossetti, Kari Bosch, Raffaella Molteni, Marco A Riva, Johanneke E Van der Harst, Huu Phuc Nguyen, Judith R Homberg
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192289 (2018)
BACKGROUND:Huntington disease (HD) is a devastating inherited neurodegenerative disorder characterized by progressive motor, cognitive, and psychiatric symptoms without any cure to slow down or stop the progress of the disease. The BACHD rat model fo
Externí odkaz:
https://doaj.org/article/7d1dde89d98946568d562c0ea895bf4e
Autor:
Arianna Novati, Libo Yu-Taeger, Irene Gonzalez Menendez, Leticia Quintanilla Martinez, Huu Phuc Nguyen
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198338 (2018)
BACKGROUND:Huntington disease (HD) is an autosomal dominant neurodegenerative disorder caused by a mutation in the huntingtin (HTT) gene, which results in brain neurodegeneration and peripheral pathology affecting different organs including testis. P
Externí odkaz:
https://doaj.org/article/c0e1405fca6844bbb8e112bdad3c6689
Autor:
Libo Yu-Taeger, Janice Stricker-Shaver, Katrin Arnold, Patrycja Bambynek-Dziuk, Arianna Novati, Elisabeth Singer, Ali Lourhmati, Claire Fabian, Janine Magg, Olaf Riess, Matthias Schwab, Alexandra Stolzing, Lusine Danielyan, Hoa Huu Phuc Nguyen
Publikováno v:
Cells, Vol 8, Iss 6, p 595 (2019)
Intrastriatal administration of mesenchymal stem cells (MSCs) has shown beneficial effects in rodent models of Huntington disease (HD). However, the invasive nature of surgical procedure and its potential to trigger the host immune response may limit
Externí odkaz:
https://doaj.org/article/a1cc28f483b44180a8ee4c7e39c3904f
Autor:
Libo Yu-Taeger, Arianna Novati, Jonasz Jeremiasz Weber, Elisabeth Singer-Mikosch, Ann-Sophie Pabst, Carsten Saft, Jennifer König, Gisa Ellrichmann, Taneli Heikkinen, Mahmoud A Pouladi, Olaf Riess, Huu Phuc Nguyen
Publikováno v:
A: Pathogenic mechanisms.
Publikováno v:
Ageing and Neurodegenerative Diseases. 2:17
No single animal model can recapitulate all the features of a particular human disease on its own. Historically, rats have been used to study neurobiology and underlying functional networks. Likewise, rat models have been created to study neurodegene
Autor:
Johanneke E. Van der Harst, Robert Wronski, Judith R. Homberg, Huu Phuc Nguyen, Giuseppe Manfré, Arianna Novati, Stefanie Flunkert
Publikováno v:
Behavioural Brain Research, 393
Behavioural Brain Research
Behavioural Brain Research
Huntington disease (HD) is a neurodegenerative disorder caused by a polyglutamine expansion in the HTT gene. Various HD animal models have been generated to mimic the motor, cognitive and neuropsychiatric disturbances that affect HD patients. Reprodu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c371df903abd16fd74f30e40af6397
http://hdl.handle.net/2066/221717
http://hdl.handle.net/2066/221717
Autor:
Arianna Novati, Huu Phuc Nguyen, Judith R. Homberg, Giuseppe Manfré, Ilaria Faccini, Johanneke E. Van der Harst
Publikováno v:
Models for HD.
Background Social behavior related symptoms and sexual disturbances are frequently reported in Huntington disease (HD) patients, but scarcely studied in animal models. The BACHD rat model for HD carries the human full length mutated HTT with 97 CAG-C
Autor:
Julia M. Schulze-Hentrich, Olaf Riess, Huu Phuc Nguyen, Thomas Hentrich, Zinah Wassouf, Arianna Novati
Publikováno v:
Models for HD.
Background Huntington disease (HD) is a progressive neurodegenerative disorder caused by a mutation in the huntingtin (HTT) gene. Despite being a monogenic disease, environmental factors can modulate HD phenotype. Specifically, environmental enrichme