Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Arianna Loregian"'
Autor:
Ilaria Giacchello, Annarita Cianciusi, Chiara Bertagnin, Anna Bonomini, Valeria Francesconi, Mattia Mori, Anna Carbone, Francesca Musumeci, Arianna Loregian, Silvia Schenone
Publikováno v:
Pharmaceutics, Vol 16, Iss 7, p 954 (2024)
The limited range of available flu treatments due to virus mutations and drug resistance have prompted the search for new therapies. RNA-dependent RNA polymerase (RdRp) is a heterotrimeric complex of three subunits, i.e., polymerase acidic protein (P
Externí odkaz:
https://doaj.org/article/c6335ef946f64501a6e9753dc49c8aac
Autor:
Jiwei Zhang, Chuanfeng Liu, Ruifang Jia, Xujie Zhang, Jian Zhang, Chiara Bertagnin, Anna Bonomini, Laura Guizzo, Yuanmin Jiang, Huinan Jia, Shuzhen Jia, Xiuli Ma, Arianna Loregian, Bing Huang, Peng Zhan, Xinyong Liu
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Our previous studies have shown that the introduction of structurally diverse benzyl side chains at the C5-NH2 position of oseltamivir to occupy 150-cavity contributes to the binding affinity with neuraminidase and anti-influenza activity. To obtain
Externí odkaz:
https://doaj.org/article/a4419431b0c841629e51f9bfcfca63f1
Autor:
Lingxin Hou, Ying Zhang, Han Ju, Srinivasulu Cherukupalli, Ruifang Jia, Jian Zhang, Bing Huang, Arianna Loregian, Xinyong Liu, Peng Zhan
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 4, Pp 1805-1824 (2022)
Influenza is an acute respiratory infectious disease caused by the influenza virus, affecting people globally and causing significant social and economic losses. Due to the inevitable limitations of vaccines and approved drugs, there is an urgent nee
Externí odkaz:
https://doaj.org/article/26988f47f16d44bc9257b7ef9a85150e
Autor:
Marta Celegato, Mattia Sturlese, Vivian Vasconcelos Costa, Marta Trevisan, Angélica Samer Lallo Dias, Ingredy Beatriz Souza Passos, Celso Martins Queiroz-Junior, Lorenzo Messa, Annagiulia Favaro, Stefano Moro, Mauro Martins Teixeira, Arianna Loregian, Beatrice Mercorelli
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT Every year, dengue virus (DENV) causes one hundred million infections worldwide that can result in dengue disease and severe dengue. Two other mosquito-borne flaviviruses, i.e., Zika virus (ZIKV) and West Nile virus (WNV), are responsible of
Externí odkaz:
https://doaj.org/article/7d5350960a884be4aa4320b1c5c46d8d
Autor:
Ruifang Jia, Jiwei Zhang, Jian Zhang, Chiara Bertagnin, Anna Bonomini, Laura Guizzo, Zhen Gao, Xiangkai Ji, Zhuo Li, Chuanfeng Liu, Han Ju, Xiuli Ma, Arianna Loregian, Bing Huang, Peng Zhan, Xinyong Liu
Publikováno v:
Molecules, Vol 27, Iss 19, p 6426 (2022)
To address drug resistance to influenza virus neuraminidase inhibitors (NAIs), a series of novel boron-containing N-substituted oseltamivir derivatives were designed and synthesized to target the 150-cavity of neuraminidase (NA). In NA inhibitory ass
Externí odkaz:
https://doaj.org/article/31d58646425e4f5fae5d75af1d8c6889
Autor:
Hanieh Ghassabian, Federico Falchi, Martina Timmoneri, Beatrice Mercorelli, Arianna Loregian, Giorgio Palù, Gualtiero Alvisi
Publikováno v:
Viruses, Vol 13, Iss 5, p 941 (2021)
Human cytomegalovirus (HCMV) is a leading cause of severe diseases in immunocompromised individuals, including AIDS patients and transplant recipients, and in congenitally infected newborns. The utility of available drugs is limited by poor bioavaila
Externí odkaz:
https://doaj.org/article/f124bc78f2544379a860db7207c8d2b0
Autor:
Saverio G. Parisi, Arianna Loregian, Samantha Andreis, Giulio Nannetti, Silvia Cavinato, Monica Basso, Renzo Scaggiante, Federico Dal Bello, Lorenzo Messa, Anna Maria Cattelan, Giorgio Palù
Publikováno v:
International Journal of Infectious Diseases, Vol 49, Iss C, Pp 151-153 (2016)
Objectives: Effective treatment with direct-acting antiviral drugs against hepatitis C virus (HCV) is a medical need in cirrhotic HIV–HCV co-infected patients. Methods: This study investigated the plasma levels of daclatasvir (DCV) and ribavirin (R
Externí odkaz:
https://doaj.org/article/ea33f99ee10f488ea077ed968f904102
Publikováno v:
Viruses, Vol 11, Iss 2, p 117 (2019)
Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that establishes a lifelong persistence in the host through both chronic and latent states of infection [...]
Externí odkaz:
https://doaj.org/article/2e370c997d5a40c2937ddf07537d539a
Autor:
Alessandro Ripalti, Arianna Loregian, Simone Avanzi, Daria Camozzi, David A. Jans, Alvisi Gualtiero, Giorgio Palù
Publikováno v:
Viruses, Vol 5, Iss 9, Pp 2210-2234 (2013)
The Herpesvirdae family comprises several major human pathogens belonging to three distinct subfamilies. Their double stranded DNA genome is replicated in the nuclei of infected cells by a number of host and viral products. Among the latter the viral
Externí odkaz:
https://doaj.org/article/981be389d9c34667a4966ae0d8f218fb
Autor:
Elisa Sinigalia, Gualtiero Alvisi, Chiara V Segré, Beatrice Mercorelli, Giulia Muratore, Michael Winkler, He-Hsuan Hsiao, Henning Urlaub, Alessandro Ripalti, Susanna Chiocca, Giorgio Palù, Arianna Loregian
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49630 (2012)
During the replication of human cytomegalovirus (HCMV) genome, the viral DNA polymerase subunit UL44 plays a key role, as by binding both DNA and the polymerase catalytic subunit it confers processivity to the holoenzyme. However, several lines of ev
Externí odkaz:
https://doaj.org/article/7ea786dbe7164785abac51a89a6c3259