Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Arianna Fornili"'
Autor:
Saima Rehman, Anna Katarina Antonovic, Ian E. McIntire, Huaixin Zheng, Leanne Cleaver, Maria Baczynska, Carlton O. Adams, Theo Portlock, Katherine Richardson, Rosie Shaw, Alain Oregioni, Giulia Mastroianni, Sara B-M. Whittaker, Geoff Kelly, Christian D. Lorenz, Arianna Fornili, Nicholas P. Cianciotto, James A. Garnett
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Bacterial adhesion is a fundamental process which enables colonisation of niche environments and is key for infection. However, in Legionella pneumophila, the causative agent of Legionnaires’ disease, these processes are not well understoo
Externí odkaz:
https://doaj.org/article/dc482835699a4915aefeb24d5457763d
Autor:
Katarzyna W. Kliza, Wei Song, Irene Pinzuti, Simone Schaubeck, Simone Kunzelmann, David Kuntin, Arianna Fornili, Alessandro Pandini, Kay Hofmann, James A. Garnett, Benjamin Stieglitz, Koraljka Husnjak
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-15 (2024)
Abstract Signalling through TNFR1 modulates proinflammatory gene transcription and programmed cell death, and its impairment causes autoimmune diseases and cancer. NEDD4-binding protein 1 (N4BP1) is a critical suppressor of proinflammatory cytokine p
Externí odkaz:
https://doaj.org/article/c56e0ffe40c84e808168dcef7ae2ce0a
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 5, p e1011099 (2023)
The druggability of small-molecule binding sites can be significantly affected by protein motions and conformational changes. Ligand binding, protein dynamics and protein function have been shown to be closely interconnected in myosins. The breakthro
Externí odkaz:
https://doaj.org/article/1c30bbcbd22e421e8fdd01da318d4cca
Autor:
Saima Rehman, Lubov S Grigoryeva, Katherine H Richardson, Paula Corsini, Richard C White, Rosie Shaw, Theo J Portlock, Benjamin Dorgan, Zeinab S Zanjani, Arianna Fornili, Nicholas P Cianciotto, James A Garnett
Publikováno v:
PLoS Pathogens, Vol 16, Iss 5, p e1008342 (2020)
Chitinases are important enzymes that contribute to the generation of carbon and nitrogen from chitin, a long chain polymer of N-acetylglucosamine that is abundant in insects, fungi, invertebrates and fish. Although mammals do not produce chitin, chi
Externí odkaz:
https://doaj.org/article/5bca9aa67fb54fa39bc9a8df958e6add
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 11, p e1005826 (2017)
New promising avenues for the pharmacological treatment of skeletal and heart muscle diseases rely on direct sarcomeric modulators, which are molecules that can directly bind to sarcomeric proteins and either inhibit or enhance their activity. A rece
Externí odkaz:
https://doaj.org/article/9f961ec8e2a040438d68e59d3c8c6066
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79482 (2013)
Phenylalanine hydroxylase (PAH) catalyzes the conversion of L-Phe to L-Tyr. Defects in PAH activity, caused by mutations in the human gene, result in the autosomal recessively inherited disease hyperphenylalaninemia. PAH activity is regulated by mult
Externí odkaz:
https://doaj.org/article/f5b9673aa8cc4585b31bf478efdeb060
Publikováno v:
Antonovic, A K, Ochala, J & Fornili, A 2023, ' Comparative study of binding pocket structure and dynamics in cardiac and skeletal myosin ', Biophysical Journal, vol. 122, no. 1, pp. 54-62 . https://doi.org/10.1016/j.bpj.2022.11.2942
The development of small molecule myosin modulators has seen an increased effort in recent years due to their possible use in the treatment of cardiac and skeletal myopathies. Omecamtiv mecarbil (OM) is the first-in-class cardiac myotrope and the fir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a22129173e133d9d35f87718c9957a3
https://doi.org/10.1016/j.bpj.2022.11.2942
https://doi.org/10.1016/j.bpj.2022.11.2942
Publikováno v:
Journal of Chemical Theory and Computation
© 2021 The Authors. Several experimental studies indicated that large conformational changes, including partial domain unfolding, have a role in the functional mechanisms of the basic helix loop helix Per/ARNT/SIM (bHLH-PAS) transcription factors. R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab7c291e4e21fc9fdde69f5026e4e655
https://doi.org/10.1021/acs.jctc.0c01308
https://doi.org/10.1021/acs.jctc.0c01308
Publikováno v:
Journal of Chemical Information and Modeling. 60:6438-6446
Omecamtiv mecarbil (OM), currently investigated for the treatment of heart failure, is the first example of a new class of drugs (cardiac myotropes) that can modify muscle contractility by directly targeting sarcomeric proteins. Using atomistic molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a688b4196c182c6d2373de366ff230
https://doi.org/10.1021/acs.jcim.0c00953
https://doi.org/10.1021/acs.jcim.0c00953
Autor:
Audrey, Colomba, Jeroen, Claus, Forson, Gao, Roger, George, Arianna, Fornili, Angus J M, Cameron
Publikováno v:
Methods in enzymology. 667
HER3 is a potent oncogenic growth factor receptor belonging to the human epidermal growth factor (HER/EGFR) family of receptor tyrosine kinases. In contrast to other EGFR family members, HER3 is a pseudokinase, lacking functional kinase activity. As
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a0b81be09da489620b74f409b8738f27
https://pubmed.ncbi.nlm.nih.gov/35525551
https://pubmed.ncbi.nlm.nih.gov/35525551