Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Arianna Bassan"'
Autor:
Arianna Bassan, Ronald Steigerwalt, Douglas Keller, Lisa Beilke, Paul M. Bradley, Frank Bringezu, William J. Brock, Leigh Ann Burns-Naas, Jon Chambers, Kevin Cross, Michael Dorato, Rosalie Elespuru, Douglas Fuhrer, Frances Hall, Jim Hartke, Gloria D. Jahnke, Felix M. Kluxen, Eric McDuffie, Friedemann Schmidt, Jean-Pierre Valentin, David Woolley, Doris Zane, Glenn J. Myatt
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
The ICH S1B carcinogenicity global testing guideline has been recently revised with a novel addendum that describes a comprehensive integrated Weight of Evidence (WoE) approach to determine the need for a 2-year rat carcinogenicity study. In the pres
Externí odkaz:
https://doaj.org/article/3419c3b90a414f7aafa8e7a2a11aedc0
Autor:
Douglas A. Keller, Arianna Bassan, Alexander Amberg, Leigh Ann Burns Naas, Jon Chambers, Kevin Cross, Frances Hall, Gloria D. Jahnke, Amarjit Luniwal, Serena Manganelli, Jordi Mestres, Amy L. Mihalchik-Burhans, David Woolley, Raymond R. Tice
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
In silico toxicology protocols are meant to support computationally-based assessments using principles that ensure that results can be generated, recorded, communicated, archived, and then evaluated in a uniform, consistent, and reproducible manner.
Externí odkaz:
https://doaj.org/article/662e50fa83754807891531c6e030ecd7
Autor:
Glenn J, Myatt, Arianna, Bassan, Dave, Bower, Candice, Johnson, Scott, Miller, Manuela, Pavan, Kevin P, Cross
Publikováno v:
Comput Toxicol
Mechanistically-driven alternative approaches to hazard assessment invariably require a battery of tests, including both in silico models and experimental data. The decision-making process, from selection of the methods to combining the information b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::54b9706ef8d043746a7a841c16f1a627
https://pubmed.ncbi.nlm.nih.gov/35036665
https://pubmed.ncbi.nlm.nih.gov/35036665
Publikováno v:
Food and Chemical Toxicology. 173:113562
Toxic plant-produced chemicals, so-called phytotoxins, constitute a category of natural compounds belonging to a diversity of chemical classes. Some of them (e.g., alkaloids, terpenes, saponins) are associated with high toxic potency, while for many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d7bf97ee9120a64d2569829be9c95f6
https://doi.org/10.1016/j.fct.2022.113562
https://doi.org/10.1016/j.fct.2022.113562
Publikováno v:
Expert Opinion on Drug Metabolism & Toxicology. 16:651-662
Whereas in the past, (Q)SAR methods have been largely used to support the design of new drugs, in the last few decades, there has been a new interest in its applications for the assessment of drug ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::988cdceb3db0b653f4be4fcbb8925ae9
https://doi.org/10.1080/17425255.2020.1785428
https://doi.org/10.1080/17425255.2020.1785428
Autor:
Frank Bringezu, Phillip Bellion, Alexander Amberg, Jeffrey M. Birmingham, Alejandra Trejo-Martin, Glenn J. Myatt, Amy L. Mihalchik-Burhans, Amarjit Luniwal, Naomi L. Kruhlak, Rosalie K. Elespuru, Karen H. Watanabe-Sailor, Louise Neilson, Lidia Ceriani, Markus Frericks, Alessandro Brigo, John P. Rooney, Arun R. Pandiri, Helga Gerets, Alice Luu, Arianna Bassan, Angela White, Marc A. Beal, Federica Madia, Manuela Pavan, David Faulkner, Lennart T. Anger, Elena Lo Piparo, Marie C. Fortin, Jordi Mestres, Ian Crooks, David Woolley, Raymond R. Tice, Paul Fowler, Balasubramanian Manickam, David R. Jones, Cynthia V. Rider, Serena Manganelli, Juan Lopez-Belmonte, Gloria D. Jahnke, Kevin P. Cross, Romualdo Benigni
Publikováno v:
Comput Toxicol
Historically, identifying carcinogens has relied primarily on tumor studies in rodents, which require enormous resources in both money and time. In silico models have been developed for predicting rodent carcinogens but have not yet found general reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de085dd3094d276c69682e6dfe5bb402
https://europepmc.org/articles/PMC8967183/
https://europepmc.org/articles/PMC8967183/
Autor:
Jean-Pierre Valentin, Daniel P. Russo, David T. Szabo, Lidiya Stavitskaya, Patricia Ruiz, Craig Zwickl, Louise Neilson, Vinicius M. Alves, Candice Johnson, Andreas Bender, Arianna Bassan, Lennart T. Anger, Reena Sandhu, David Woolley, Lisa Beilke, Manuela Pavan, Raymond Kemper, Mark T. D. Cronin, Moiz Mumtaz, Glenn J. Myatt, Alexander Amberg, Yogesh Sabnis, Jui-Hua Hsieh, Markus Schaefer, Amy Pointon, Autumn Bernal, Julia Pletz
Publikováno v:
Comput Toxicol
The kidneys, heart and lungs are vital organ systems evaluated as part of acute or chronic toxicity assessments. New methodologies are being developed to predict these adverse effects based on in vitro and in silico approaches. This paper reviews the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e41082bb951a3c41285999b6f292588
https://europepmc.org/articles/PMC9205464/
https://europepmc.org/articles/PMC9205464/
Autor:
Simona Kovarich, Arianna Bassan, Elena Fioravanzo, Anna Palczewska, Andrea Ciacci, Daniel Neagu
Publikováno v:
Computational Toxicology. 10:130-144
The current paradigm of toxicity testing is set within a framework of Mode-of-Action (MoA)/Adverse Outcome Pathway (AOP) investigations, where novel methodologies alternative to animal testing play a crucial role, and allow to consider causal links b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a84150495604bfe517c7cacc27b44f79
https://doi.org/10.1016/j.comtox.2019.01.004
https://doi.org/10.1016/j.comtox.2019.01.004
Autor:
Kevin M. Crofton, Arianna Bassan, Mamta Behl, Yaroslav G. Chushak, Ellen Fritsche, Jeffery M. Gearhart, Mary Sue Marty, Moiz Mumtaz, Manuela Pavan, Patricia Ruiz, Magdalini Sachana, Rajamani Selvam, Timothy J. Shafer, Lidiya Stavitskaya, David T. Szabo, Steven T. Szabo, Raymond R. Tice, Dan Wilson, David Woolley, Glenn J. Myatt
Publikováno v:
Comput Toxicol
Neurotoxicology is the study of adverse effects on the structure or function of the developing or mature adult nervous system following exposure to chemical, biological, or physical agents. The development of more informative alternative methods to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f3ba94e6c068612369fa81e8dd2e651
https://doi.org/10.1016/j.comtox.2022.100223
https://doi.org/10.1016/j.comtox.2022.100223
Autor:
Glenn J. Myatt, Arianna Bassan, Dave Bower, Kevin M. Crofton, Kevin P. Cross, Jessica C. Graham, Catrin Hasselgren, Robert A. Jolly, Scott Miller, Manuela Pavan, Raymond R Tice, Craig Zwickl, Candice Johnson
Publikováno v:
Computational Toxicology. 21:100209
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::561e0b8c61bff89be3a7e52ce777e46f
https://doi.org/10.1016/j.comtox.2021.100209
https://doi.org/10.1016/j.comtox.2021.100209