Výsledky vyhledávání - "Arianna, Draghi"

Akademický článek

Dose escalation study of a personalized peptide-based neoantigen vaccine (EVX-01) in patients with metastatic melanoma

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 5 (2024)

Background Neoantigens can serve as targets for T cell-mediated antitumor immunity via personalized neopeptide vaccines. Interim data from our clinical study NCT03715985 showed that the personalized peptide-based neoantigen vaccine EVX-01, formulated

Externí odkaz: https://doaj.org/article/ba4e7a8820d44fe594ecfd552cb83643

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Akademický článek

TCR-engaging scaffolds selectively expand antigen-specific T-cells with a favorable phenotype for adoptive cell therapy

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 8 (2023)

Background Adoptive cell therapy (ACT) has shown promising results for the treatment of cancer and viral infections. Successful ACT relies on ex vivo expansion of large numbers of desired T-cells with strong cytotoxic capacity and in vivo persistence

Externí odkaz: https://doaj.org/article/a25dad34aae2492e8875e883c1894921

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Akademický článek

Personalized therapy with peptide-based neoantigen vaccine (EVX-01) including a novel adjuvant, CAF®09b, in patients with metastatic melanoma

Publikováno v: OncoImmunology, Vol 11, Iss 1 (2022)

The majority of neoantigens arise from unique mutations that are not shared between individual patients, making neoantigen-directed immunotherapy a fully personalized treatment approach. Novel technical advances in next-generation sequencing of tumor

Externí odkaz: https://doaj.org/article/7abb393630304338a7037f295b6ab061

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Akademický článek

Neoantigen-reactive CD8+ T cells affect clinical outcome of adoptive cell therapy with tumor-infiltrating lymphocytes in melanoma

Publikováno v: The Journal of Clinical Investigation, Vol 132, Iss 2 (2022)

BACKGROUND Neoantigen-driven recognition and T cell–mediated killing contribute to tumor clearance following adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs). Yet how diversity, frequency, and persistence of expanded neoepitop

Externí odkaz: https://doaj.org/article/d770acf332f045ffaf6a8379f97a7b0f

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Akademický článek

Rapid Identification of the Tumor-Specific Reactive TIL Repertoire via Combined Detection of CD137, TNF, and IFNγ, Following Recognition of Autologous Tumor-Antigens

Autor: Arianna Draghi, Christopher Aled Chamberlain, Shawez Khan, Krisztian Papp, Martin Lauss, Samuele Soraggi, Haja Dominike Radic, Mario Presti, Katja Harbst, Aishwarya Gokuldass, Anders Kverneland, Morten Nielsen, Marie Christine Wulff Westergaard, Mads Hald Andersen, Istvan Csabai, Göran Jönsson, Zoltan Szallasi, Inge Marie Svane, Marco Donia

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Detecting the entire repertoire of tumor-specific reactive tumor-infiltrating lymphocytes (TILs) is essential for investigating their immunological functions in the tumor microenvironment. Current in vitro assays identifying tumor-specific functional

Externí odkaz: https://doaj.org/article/656d1c3e4153414e9f09ed73929cd351

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Uncoupling CD4+ TIL-Mediated Tumor Killing from JAK-Signaling in Melanoma

Autor: Arianna Draghi, Mario Presti, Agnete W.P. Jensen, Christopher A. Chamberlain, Benedetta Albieri, Anne-Christine K. Rasmussen, Mads H. Andersen, Michael D. Crowther, Inge Marie Svane, Marco Donia

Publikováno v: Clinical Cancer Research. :OF1-OF11

Purpose: Impaired MHCI-presentation and insensitivity to immune effector molecules are common features of immune checkpoint blockade (ICB)-resistant tumors and can be, respectively, associated with loss of β2 microglobulin (B2M) or impaired IFNγ si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f8a1f819e95174da76e7007666bdd52
https://doi.org/10.1158/1078-0432.ccr-22-3853

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Akademický článek

762 A combination of functional biomarkers improves identification of the tumor-specific reactive T cell repertoire

Autor: Marco Donia, Arianna Draghi, Katja Harbst, Inge Svane

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)

Externí odkaz: https://doaj.org/article/8ff48f561efa436893e4e83768e62e44

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Akademický článek

Tumor-Infiltrating T Cells From Clear Cell Renal Cell Carcinoma Patients Recognize Neoepitopes Derived From Point and Frameshift Mutations

Autor: Ulla Kring Hansen, Sofie Ramskov, Anne-Mette Bjerregaard, Annie Borch, Rikke Andersen, Arianna Draghi, Marco Donia, Amalie Kai Bentzen, Andrea Marion Marquard, Zoltan Szallasi, Aron Charles Eklund, Inge Marie Svane, Sine Reker Hadrup

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Mutation-derived neoantigens are important targets for T cell-mediated reactivity toward tumors and, due to their unique tumor expression, an attractive target for immunotherapy. Neoepitope-specific T cells have been detected across a number of solid

Externí odkaz: https://doaj.org/article/0da0b48b1adc4d6d9aabde94720619bf

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