Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ariane J Brown"'
Autor:
Timothy P. Sheahan, Amy C. Sims, Sarah R. Leist, Alexandra Schäfer, John Won, Ariane J. Brown, Stephanie A. Montgomery, Alison Hogg, Darius Babusis, Michael O. Clarke, Jamie E. Spahn, Laura Bauer, Scott Sellers, Danielle Porter, Joy Y. Feng, Tomas Cihlar, Robert Jordan, Mark R. Denison, Ralph S. Baric
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Remdesivir (RDV) is a broad-spectrum antiviral drug with activity against MERS coronavirus, but in vivo efficacy has not been evaluated. Here, the authors show that RDV has superior anti-MERS activity in vitro and in vivo compared to combination ther
Externí odkaz:
https://doaj.org/article/f17353d0fecb47bb853401bd79786ace
Autor:
Ariane J. Brown, John J. Won, Raphael Wolfisberg, Ulrik Fahnøe, Nicholas Catanzaro, Ande West, Fernando R. Moreira, Mariana Nogueira Batista, Martin T. Ferris, Colton L. Linnertz, Sarah R. Leist, Cameron Nguyen, Gabriela De la Cruz, Bentley R. Midkiff, Yongjuan Xia, Stephanie A. Montgomery, Eva Billerbeck, Jens Bukh, Troels K.H. Scheel, Charles M. Rice, Timothy P. Sheahan
Background & AimsHuman genetic variation is thought to guide the outcome of hepatitis C virus (HCV) infection but model systems within which to dissect these host genetic mechanisms are limited. Norway rat hepacivirus (NrHV), closely related to HCV,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24302a1c3ae6256ada68575f8a75f1a9
https://doi.org/10.1101/2023.03.18.533278
https://doi.org/10.1101/2023.03.18.533278
Autor:
Alexandra Schäfer, Boyd Yount, Ariane J. Brown, Caitlin E. Edwards, Stephanie A. Montgomery, Ande West, Ralph S. Baric, Kendra Gully, Yixuan J. Hou, David R. Martinez, Lily E. Adams, Jeffrey S. Glenn, Matthew D. Bryant, Emily Huang, Lisa E. Gralinski, Timothy P. Sheahan, Ingrid Choong, Sarah R. Leist, Kenneth H. Dinnon
Publikováno v:
Nature
Coronaviruses are prone to transmission to new host species, as recently demonstrated by the spread to humans of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease 2019 (COVID-19) pandemic1. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d405c70c1a4b9bf3a41c639cd2ce35a0
http://europepmc.org/articles/PMC8034761
http://europepmc.org/articles/PMC8034761
Autor:
John J. Won, Michael O'neil Hanrahan Clarke, Alison Hogg, Ralph S. Baric, Mark R. Denison, Tomas Cihlar, Darius Babusis, Timothy P. Sheahan, Joy Y. Feng, Ariane J. Brown, Sarah R. Leist, Danielle P. Porter, Bauer Laura Elizabeth, Alexandra Schäfer, Jamie E. Spahn, Stephanie A. Montgomery, Amy C. Sims, Robert Jordan, Scott P. Sellers
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications, 11:222
Nature Communications
Nature Communications, 11:222
Middle East respiratory syndrome coronavirus (MERS-CoV) is the causative agent of a severe respiratory disease associated with more than 2468 human infections and over 851 deaths in 27 countries since 2012. There are no approved treatments for MERS-C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45489d029ed8ca9d2cc6e29602478e87
https://doaj.org/article/f17353d0fecb47bb853401bd79786ace
https://doaj.org/article/f17353d0fecb47bb853401bd79786ace
Autor:
Alexandra Schäfer, David R. Martinez, John J. Won, Rita M. Meganck, Fernando R. Moreira, Ariane J. Brown, Kendra L. Gully, Mark R. Zweigart, William S. Conrad, Samantha R. May, Stephanie Dong, Rao Kalla, Kwon Chun, Venice Du Pont, Darius Babusis, Jennifer Tang, Eisuke Murakami, Raju Subramanian, Kimberly T. Barrett, Blake J. Bleier, Roy Bannister, Joy Y. Feng, John P. Bilello, Tomas Cihlar, Richard L. Mackman, Stephanie A. Montgomery, Ralph S. Baric, Timothy P. Sheahan
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 3
article-version (status) pre
article-version (number) 3
The coronavirus disease 2019 (COVID-19) pandemic remains uncontrolled despite the rapid rollout of safe and effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines, underscoring the need to develop highly effective antivirals.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::414bac2018cc4bd1b40a45769213931b
Autor:
Katie R Mollan, Joseph J Eron, Taylor J Krajewski, Wendy Painter, Elizabeth R Duke, Caryn G Morse, Erin A Goecker, Lakshmanane Premkumar, Cameron R Wolfe, Laura J Szewczyk, Paul L Alabanza, Amy James Loftis, Emily J Degli-Angeli, Ariane J Brown, Joan A Dragavon, John J Won, Jessica Keys, Michael G Hudgens, Lei Fang, David A Wohl, Myron S Cohen, Ralph S Baric, Robert W Coombs, Timothy P Sheahan, William A Fischer
Publikováno v:
Clin Infect Dis
Background Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectious virus isolation in outpatients with coronavirus disease 2019 (COVID-19) has been associated with viral RNA levels and symptom duration, little is known about
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12f31f7dab0d81bbcca208a91619e07a
https://europepmc.org/articles/PMC9402664/
https://europepmc.org/articles/PMC9402664/
Autor:
Jennifer Tang, Timothy P. Sheahan, Stephanie A. Montgomery, Kendra Gully, John J. Won, Ariane J. Brown, Tomas Cihlar, Joy Y. Feng, Ralph S. Baric, Fernanado R Moreira, Kimberly T Barrett, Eisuke Murakami, Roy Bannister, Raju Subramanian, John P. Bilello, Richard L. Mackman, Darius Babusis, Venice Du Pont, Rao Kalla, David R. Martinez, Blake J. Bleier, Kwon Soo Chun, Alexandra Schäfer
The COVID-19 pandemic remains uncontrolled despite the rapid rollout of safe and effective SARS-CoV-2 vaccines, underscoring the need to develop highly effective antivirals. In the setting of waning immunity from infection and vaccination, breakthrou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce6015bc48077307a089bd765f513bb
https://doi.org/10.1101/2021.09.13.460111
https://doi.org/10.1101/2021.09.13.460111
Infectious SARS-CoV-2 Virus in Symptomatic COVID-19 Outpatients: Host, Disease, and Viral Correlates
Autor:
Robert W. Coombs, Ariane J. Brown, Myron S. Cohen, David A. Wohl, Joan Dragavon, John J. Won, William A. Fischer, Timothy P. Sheahan, Elizabeth R. Duke, Ralph S. Baric, Cameron R. Wolfe, Taylor J. Krajewski, Laura J. Szewczyk, Emily J. Degli-Angeli, Amy James Loftis, Caryn G. Morse, Paul Alabanza, Michael G. Hudgens, Lei Fang, Erin A. Goecker, Katie R. Mollan, Lakshmanane Premkumar, Wendy Painter, Jessica Keys, Joseph J. Eron
Background SARS-CoV-2 infectious virus isolation in the upper airway of COVID-19 patients is associated with higher levels of viral RNA. However, comprehensive evaluation of the relationships between host and disease factors and infectious, replicati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efc3f7f53ebbef638450729f002a0e0f
https://doi.org/10.1101/2021.05.28.21258011
https://doi.org/10.1101/2021.05.28.21258011
Autor:
Sarah R. Leist, Kenneth H. Dinnon, Yixuan J. Hou, Lisa E. Gralinski, Timothy P. Sheahan, Matthew D. Bryant, Kendra Gully, Boyd Yount, Caitlin E. Edwards, Ande West, Stephanie A. Montgomery, Alexandra Schäfer, Ariane J. Brown, Ralph S. Baric, David R. Martinez, Lily E. Adams, Jeffrey S. Glenn, Emily Huang, Ingrid Choong
Publikováno v:
bioRxiv
Coronaviruses are prone to emergence into new host species most recently evidenced by SARS-CoV-2, the causative agent of the COVID-19 pandemic. Small animal models that recapitulate SARS-CoV-2 disease are desperately needed to rapidly evaluate medica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d16d8241b532ba6152f3960789e96c37
https://doi.org/10.1101/2020.05.06.081497
https://doi.org/10.1101/2020.05.06.081497
Autor:
Laura J. Stevens, Mark R. Denison, Alexandra Schäfer, James D. Chappell, Bin Ma, David R. Martinez, Maria L. Agostini, Jason K. Perry, Rachel L. Graham, John P. Bilello, Jared Pitts, Kendra Gully, Danielle Porter, Ariane J. Brown, Eisuke Murakami, Venice Du Pont, Timothy P. Sheahan, Sarah R. Leist, Kenneth H. Dinnon, Darius Babusis, Boyd Yount, Lisa E. Gralinksi, Tia M. Hughes, Ralph S. Baric, Joy Y. Feng, Xiaotao Lu, Andrea J. Pruijssers, Tomas Cihlar, Amelia S. George
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in 2019 as the causative agent of the novel pandemic viral disease COVID-19. With no approved therapies, this pandemic illustrates the urgent need for safe, broad-spectrum antiviral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55d39047893773d908934086bdfb9634