Výsledky vyhledávání - "Ariana Jacome"

Akademický článek

α-tubulin detyrosination fine-tunes kinetochore-microtubule attachments

Autor: Hugo Girão, Joana Macário-Monteiro, Ana C. Figueiredo, Ricardo Silva e Sousa, Elena Doria, Vladimir Demidov, Hugo Osório, Ariana Jacome, Patrick Meraldi, Ekaterina L. Grishchuk, Helder Maiato

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

Abstract Post-translational cycles of α-tubulin detyrosination and tyrosination generate microtubule diversity, the cellular functions of which remain largely unknown. Here we show that α-tubulin detyrosination regulates kinetochore-microtubule att

Externí odkaz: https://doaj.org/article/920deb434b9b43b78cca1c970eb4ae62

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Akademický článek

Bcr/Abl interferes with the Fanconi anemia/BRCA pathway: implications in the chromosomal instability of chronic myeloid leukemia cells.

Autor: Antonio Valeri, Maria Eugenia Alonso-Ferrero, Paula Río, María Roser Pujol, José A Casado, Laura Pérez, Ariana Jacome, Xabier Agirre, Maria José Calasanz, Helmut Hanenberg, Jordi Surrallés, Felipe Prosper, Beatriz Albella, Juan A Bueren

Publikováno v: PLoS ONE, Vol 5, Iss 12, p e15525 (2010)

Chronic myeloid leukemia (CML) is a malignant clonal disorder of the hematopoietic system caused by the expression of the BCR/ABL fusion oncogene. Although it is well known that CML cells are genetically unstable, the mechanisms accounting for this g

Externí odkaz: https://doaj.org/article/b4a584191bc246d394dc616a54cccc04

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Can the Synergic Contribution of Multigenic Variants Explain the Clinical and Cellular Phenotypes of a Neurodevelopmental Disorder?

Autor: Nuno Maia, Maria João Nabais Sá, Cláudia Oliveira, Flávia Santos, Célia Azevedo Soares, Catarina Prior, Nataliya Tkachenko, Rosário Santos, Arjan P. M. de Brouwer, Ariana Jacome, Beatriz Porto, Paula Jorge

Publikováno v: Genes, 13, 1
Genes, 13
Genes
Genes, Vol 13, Iss 78, p 78 (2022)
Genes; Volume 13; Issue 1; Pages: 78

We describe an infant female with a syndromic neurodevelopmental clinical phenotype and increased chromosome instability as cellular phenotype. Genotype characterization revealed heterozygous variants in genes directly or indirectly linked to DNA rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ad36ef45ecf8a881e32066fe1664e9
https://repository.ubn.ru.nl/handle/2066/247113

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Microtubule poleward flux in human cells is driven by the coordinated action of four kinesins

Autor: Ariana Jacome, Stephan Geley, Yulia Steblyanko, Girish Rajendraprasad, Helder Maiato, Marin Barisic, António J. Pereira, Mariana Osswald, Susana Eibes

Publikováno v: EMBO J

Mitotic spindle microtubules (MTs) undergo continuous poleward flux, whose driving force and function in humans remain unclear. Here, we combined loss‐of‐function screenings with analysis of MT‐dynamics in human cells to investigate the molecul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1308bc33efdbccab773babd306c011fb
https://doi.org/10.15252/embj.2020105432

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NSMCE 2 suppresses cancer and aging in mice independently of its SUMO ligase activity

Autor: Matilde Murga, Juan Méndez, Federica Schiavoni, Sara Rodriguez-Acebes, Paula Martinez, Maria A. Blasco, Enrico Tenaglia, Oscar Fernandez-Capetillo, Paula Gutierrez-Martinez, Ariana Jacome, Emilio Lecona

Publikováno v: The EMBO Journal. 34:2604-2619

The SMC5/6 complex is the least understood of SMC complexes. In yeast, smc5/6 mutants phenocopy mutations in sgs1, the BLM ortholog that is deficient in Bloom's syndrome (BS). We here show that NSMCE2 (Mms21, in Saccharomyces cerevisiae), an essentia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f06c72e5cfe7e8920baf63eac0bf4d2c
https://doi.org/10.15252/embj.201591829

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Development of Lentiviral Vectors with Optimized Transcriptional Activity for the Gene Therapy of Patients with Fanconi Anemia

Autor: Guillermo Guenechea, José C. Segovia, Susana Navarro, Juan A. Bueren, M. Luz Lozano, Paula Río, Ariana Jacome, Lara Álvarez, África González-Murillo, Helmut Hanenberg, Elena Almarza

Publikováno v: Human Gene Therapy. 21:623-630

Fanconi anemia (FA) is an inherited genetic disease characterized mainly by bone marrow failure and cancer predisposition. Although gene therapy may constitute a good therapeutic option for many patients with FA, none of the clinical trials so far de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cc95661de5ae99d8adf3a63918b395e
https://doi.org/10.1089/hum.2009.141

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A Simplified Approach to Improve the Efficiency and Safety ofEx VivoHematopoietic Gene Therapy in Fanconi Anemia Patients

Autor: Juan Ortega, Jose-Carlos Segovia, Juan A. Bueren, L Madero, Isabel Badell, Paula Río, Julián Sevilla, Ariana Jacome, José A. Casado, Jesús Estella, T. Olivé, Helmut Hanenberg, Susana Navarro

Publikováno v: Human Gene Therapy. 17:245-250

Fanconi anemia (FA) is an inherited DNA repair disorder characterized by genetic instability of cells lacking a functional FA/BRCA pathway. Previous studies have shown that in vitro stimulation of bone marrow cells (BMCs) from FA mice promotes apopto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8afe1eaf3b03a0cc782052953a1c0fda
https://doi.org/10.1089/hum.2006.17.245

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Lac operator repeats generate a traceable fragile site in mammalian cells

Autor: Oscar Fernandez-Capetillo, Ariana Jacome

Publikováno v: EMBO reports

One limitation for the study of chromosomal fragile sites is that they must be studied on metaphase spreads, after the breakage. We show here that bacterial lac operator (lacO) repeats are prone to spontaneous breakage, which when combined with a flu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b28594c5d6ef352258c0acf1b56a440

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Bcr/Abl interferes with the Fanconi anemia/BRCA pathway: implications in the chromosomal instability of chronic myeloid leukemia cells

Autor: Ariana Jacome, Laura Fátima Asensi Pérez, Xabier Agirre, Helmut Hanenberg, Jordi Surrallés, María José Calasanz, Juan A. Bueren, ME Alonso-Ferrero, Paula Río, Maria Roser Pujol, Antonio Valeri, José A. Casado, Beatriz Albella, Felipe Prosper

Publikováno v: PLoS ONE, Vol 5, Iss 12, p e15525 (2010)
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Dadun. Depósito Académico Digital de la Universidad de Navarra
instname
PLoS ONE
Recercat. Dipósit de la Recerca de Catalunya
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona

This work was supported by grants from the European Program "Life Sciences, Genomics and Biotechnology for Health" (CONSERT; Ref LSHB-CT-2004- 5242), Centro de Investigacio'n en Red de Enfermedades Raras (CIBERER), Comisión Interministerial de Cienc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d308fe1c593c3bea64a2b2ca6bf6c66
http://europepmc.org/articles/PMC3011007?pdf=render

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