Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ariana C. Detwiler"'
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 12, Iss 4 (2022)
AbstractNecrosis was once described as a chaotic unregulated response to cellular insult. We now know that necrosis is controlled by multiple pathways in response to many different cellular conditions. In our pnc-1+Caenorhabditis eleganspnc-1C. elega
Externí odkaz:
https://doaj.org/article/9efe2966dfa345f3a16f908c66342848
Autor:
Ming Liu, Hai Pan, Parminder Kaur, Lucia J. Wang, Miao Jin, Ariana C. Detwiler, Patricia L. Opresko, Yizhi Jane Tao, Hong Wang, Robert Riehn
Publikováno v:
Biophysical Journal. 122:1822-1832
Autor:
Ryan P. Barnes, Mariarosaria de Rosa, Sanjana A. Thosar, Ariana C. Detwiler, Vera Roginskaya, Bennett Van Houten, Marcel P. Bruchez, Jacob Stewart-Ornstein, Patricia L. Opresko
Publikováno v:
Nature Structural & Molecular Biology. 29:639-652
Oxidative stress is a primary cause of cellular senescence and contributes to the etiology of numerous human diseases. Oxidative damage to telomeric DNA has been proposed to cause premature senescence by accelerating telomere shortening. Here, we tes
Autor:
Parminder Kaur, Ryan Barnes, Hai Pan, Ariana C Detwiler, Ming Liu, Chelsea Mahn, Jonathan Hall, Zach Messenger, Changjiang You, Jacob Piehler, Robert C Smart, Robert Riehn, Patricia L Opresko, Hong Wang
Publikováno v:
Nucleic Acids Research
The telomere specific shelterin complex, which includes TRF1, TRF2, RAP1, TIN2, TPP1 and POT1, prevents spurious recognition of telomeres as double-strand DNA breaks and regulates telomerase and DNA repair activities at telomeres. TIN2 is a key compo
Autor:
Saroj Dangi, Ming Liu, Zubair Azad, Preston Countryman, Maedeh Roushan, Gideon I. Livshits, Parminder Kaur, Hai Pan, Zhubing Shi, Ariana C. Detwiler, Patricia L. Opresko, Hongtao Yu, Hong Wang, Robert Riehn
Single-molecule techniques provide important details supplementing the framework obtained from traditional bulk experiments. Many cellular processes such as DNA replication, DNA repair, and telomere maintenance involve interaction among multiple prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e085b61e38dbe544779919497b3f5a73
https://doi.org/10.1101/2022.12.29.521498
https://doi.org/10.1101/2022.12.29.521498
Autor:
Patricia L. Opresko, Ryan P. Barnes, Roginskaya, Ariana C. Detwiler, Jacob Stewart-Ornstein, Thosar Sa, Van Houten B, de Rosa M, Marcel P. Bruchez
SUMMARYOxidative stress is a primary cause of cellular senescence and contributes to the pathogenesis of numerous human diseases. Oxidative damage to telomeric DNA is proposed to trigger premature senescence by accelerating telomere shortening. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08e202cafc77a13374601dd1e3643c13
https://doi.org/10.1101/2021.05.05.442662
https://doi.org/10.1101/2021.05.05.442662
Autor:
Santanu De, Srinivasan Vijayaraghavan, Ariana C. Detwiler, Eva Gilker, Alaa Eisa, Douglas Kline, Alexander C. Ignatious
Publikováno v:
BMC Developmental Biology
BMC Developmental Biology, Vol 19, Iss 1, Pp 1-22 (2019)
BMC Developmental Biology, Vol 19, Iss 1, Pp 1-22 (2019)
BackgroundImmature mammalian oocytes are held arrested at prophase I of meiosis by an inhibitory phosphorylation of cyclin-dependent kinase 1 (CDK1). Release from this meiotic arrest and germinal vesicle breakdown is dependent on dephosphorylation of
Autor:
Dhruv Bhattaram, Ming Liu, Samantha L. Sanford, Ariana C. Detwiler, Robert Riehn, Guozhou Xu, Pengyu Hao, Pengning Xu, Jacob Piehler, Patricia L. Opresko, Changjiang You, Warren Lu, Hai Pan, Chelsea Mahn, Hong Wang, Xinyun Gu, Ryan P. Barnes, Qingyu Tang, Parminder Kaur, Keith Weninger
Publikováno v:
The Journal of Biological Chemistry
TIN2 is a core component of the shelterin complex linking double-stranded telomeric DNA-binding proteins (TRF1 and TRF2) and single-strand overhang-binding proteins (TPP1-POT1). In vivo, the large majority of TRF1 and TRF2 exist in complexes containi
Autor:
Ineke Dhondt, Marisa J. Pacella, Jimmy F. Goncalves, Wendy Hanna-Rose, Kelvin Kho, Wenqing Wang, Stephanie E. Lange, Bart P. Braeckman, Melanie R. McReynolds, Muya Shu, Ariana C. Detwiler
Publikováno v:
Journal of Biological Chemistry. 290:26163-26179
Temporal developmental progression is highly coordinated in Caenorhabditis elegans. However, loss of nicotinamidase PNC-1 activity slows reproductive development, uncoupling it from its typical progression relative to the soma. Using LC/MS we demonst