Evolution and Clinical Impact of EGFR Mutations in Circulating Free DNA in the BELIEF Trial

Autor: Niki Karachaliou, Zoi Tsourti, Bartomeu Massuti, Santiago Ponce Aix, Martin Früh, Miklos Pless, Paolo Bidoli, Núria Jordana-Ariza, Ariadna Balada-Bel, H. Roschitzki-Voser, Enriqueta Felip, Solange Peters, Mónica Garzón-Ibáñez, Roswitha Kammler, Ramon Palmero, Sinead Cuffe, Clara Mayo-de-las-Casas, Rafael Rosell, Sanjay Popat, Enric Carcereny, M.A. Molina-Vila, Oliver Gautschi, Beatriz García-Peláez, Rolf A. Stahel, Urania Dafni, Alessandra Curioni Fontecedro

Publikováno v: Journal of Thoracic Oncology
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Universidad de Alicante (UA)
JOURNAL OF THORACIC ONCOLOGY
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname
r-IGTP: Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Institut de Recerca Germans Trias i Pujol (IGTP)

Introduction: Longitudinal evaluation of mutations in blood samples was a prespecified secondary objective in the BELIEF trial of erlotinib and bevacizumab in advanced EGFR-positive NSCLC. Here, we report the testing results and explore the correlati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::994673a7e864203d23813318e7ec156a
http://hdl.handle.net/10281/260723

Prospective analysis of liquid biopsies of advanced non-small cell lung cancer patients after progression to targeted therapies using GeneReader NGS platform

Autor: Clara Mayo de las Casas, Mónica Garzón-Ibañez, Núria Jordana-Ariza, Santiago Viteri-Ramírez, Irene Moya-Horno, Niki Karachaliou, Zaira Yeste, Raquel Campos, Sergi Villatoro, Ariadna Balada-Bel, Beatriz García-Peláez, Noemí Reguart, Cristina Teixidó, Eloisa Jantús, Silvia Calabuig, Cristina Aguado, Ana Giménez-Capitán, Ruth Román-Lladó, Ana Pérez-Rosado, Maria José Catalán, Jordi Bertrán-Alamillo, Silvia García-Román, Sonia Rodriguez, Lidia Alonso, Erika Aldeguer, Alejandro Martínez-Bueno, Maria González-Cao, Andrés Aguilar Hernandez, Juan Garcia-Mosquera, Maria de los Llanos Gil, Manuel Fernandez, Rafael Rosell, Miguel Ángel Molina-Vila

Publikováno v: Translational Cancer Research
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname

Background: In a significant percentage of advanced non-small cell lung cancer (NSCLC) patients, tumor tissue is unavailable or insufficient for genetic analyses at time to progression. We prospectively analyzed the appearance of genetic alterations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89900d376e87821da5a898aa2ba2315e
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2879

Abstract 1384: nCounter for detection of clinically relevant alterations in liquid biopsies of solid tumor patients

Autor: Ana A. Giménez-Capitán, Chung-Ying Huang, Jill Bracht, Rich Boykin, Clara Mayo-de-las-Casas, Joseph M. Beechem, Cristina Teixidó, Ariadna Balada-Bel, Beatriz Garcia, Sergio Villatoro, Monica Garzón, Nuria Jordana-Ariza, Cristina Aguado, Santiago Viteri, Juan José García, Rafael Rosell, Jay Gerlach, Noemi Reguart, Miguel Angel Molina-Vila

Publikováno v: Cancer Research. 79:1384-1384

Background: With the advent of precision medicine, screening for clinically relevant mutations and gene fusions is mandatory in many tumor types. However, in a significant number of cancer patients, the tumor tissue available is insufficient for gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::edc4492efff4c53f8a00993fe35c625b
https://doi.org/10.1158/1538-7445.am2019-1384

Abstract 3643: Utility of peritoneal and pleural lavages for detection of somatic alterations: A proof-of-concept study

Autor: Clara Mayo de las Casas, Raquel Campos Fuentes, Sergi Villatoro, Ana Velasco, Beatriz Garcia, M. C. Ruiz, Berta Roman Canal, Mónica Garzón Ibañez, Ariadna Balada Bel, Sonia Gatius Caldero, Xavier Matias-Guiu, Miguel Angel Molina-Vila, Alejandro Martinez-Bueno, Jordi Bertran Alamillo, Sonia Rodríguez Muñoz, Nuria Jordana Ariza

Publikováno v: Cancer Research. 78:3643-3643

Background: Surgical resection remains the best treatment option for early-stage endometrial (CE), colorectal (CRC) and lung cancer (LC) patients. However, a proportion of patients (p) develop tumor recurrence, even after curative resection. Peritone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5deeb0158ab9c3e3e6d0ff3313b8f2d4
https://doi.org/10.1158/1538-7445.am2018-3643

Abstract 5688: Routine testing for KRAS mutations in cfDNA from blood of advanced cancer patients

Autor: Alejandro Martinez-Bueno, Beatriz Garcia, Sergio Villatoro, Maria José Catalán, Santiago Viteri Ramirez, Rafael Rosell, Nuria Jordana Ariza, Niki Karachaliou, Daniela Morales Espinosa, Jordi Bertran-Alamillo, Clara Mayo de las Casas, Ariadna Balada Bel, Miguel Angel Molina-Vila, Mónica Garzón Ibañez, Ana Pérez Rosado

Publikováno v: Cancer Research. 77:5688-5688

Background: Mutations in the KRAS proto-oncogene, GTPase (KRAS) are driver alterations in several tumors, such as non-small-cell lung (NSCLC) and colorectal cancer (CRC). However, their role as a prognostic marker in liquid biopsies is unclear. We st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7472962e00522ffbffc852d96146f8ae
https://doi.org/10.1158/1538-7445.am2017-5688