Výsledky vyhledávání - "Ari-Pekka Koivisto"

Akademický článek

Targeting TRP Channels for Pain, Itch and Neurogenic Inflammation

Autor: Ari-Pekka Koivisto, Arpad Szallasi

Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 1, p 320 (2023)

Transient receptor potential (TRP) channels are multifunctional signaling molecules with important roles in health and disease [...]

Externí odkaz: https://doaj.org/article/28ce46ad1c274b09b72f785c93a3cc41

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Akademický článek

Inhibition of Canonical Transient Receptor Potential Channels 4/5 with Highly Selective and Potent Small-Molecule HC-070 Alleviates Mechanical Hypersensitivity in Rat Models of Visceral and Neuropathic Pain

Autor: Niina Jalava, Janne Kaskinoro, Hugh Chapman, Miguel Morales, Hanna Metsänkylä, Satu-Maarit Heinonen, Ari-Pekka Koivisto

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 4, p 3350 (2023)

Transient receptor potential channels C4/C5 are widely expressed in the pain pathway. Here, we studied the putative analgesic efficacy of the highly selective and potent TRPC4/C5 antagonist HC-070 in rats. Inhibitory potency on human TRPC4 was assess

Externí odkaz: https://doaj.org/article/225d91f559694aa19e93c68611dd103d

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Akademický článek

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Akademický článek

Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture

Autor: Anna L. Lahti, Ville J. Kujala, Hugh Chapman, Ari-Pekka Koivisto, Mari Pekkanen-Mattila, Erja Kerkelä, Jari Hyttinen, Kimmo Kontula, Heikki Swan, Bruce R. Conklin, Shinya Yamanaka, Olli Silvennoinen, Katriina Aalto-Setälä

Publikováno v: Disease Models & Mechanisms, Vol 5, Iss 2, Pp 220-230 (2012)

SUMMARY Long QT syndrome (LQTS) is caused by functional alterations in cardiac ion channels and is associated with prolonged cardiac repolarization time and increased risk of ventricular arrhythmias. Inherited type 2 LQTS (LQT2) and drug-induced LQTS

Externí odkaz: https://doaj.org/article/4cc60259a6974a38becc0e0ca2a95b62

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