Zobrazeno 1 - 10
of 442
pro vyhledávání: '"Ari Waisman"'
Publikováno v:
Immunity & Ageing, Vol 21, Iss 1, Pp 1-18 (2024)
Abstract B-1 cells have intricate biology, with distinct function, phenotype and developmental origin from conventional B cells. They generate a B cell receptor with conserved germline characteristics and biased V(D)J recombination, allowing this inn
Externí odkaz:
https://doaj.org/article/f166d4bd8be746d8b5f511186de1f3b5
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103154- (2024)
Summary: The intestinal lamina propria (LP) is a leukocyte-rich cornerstone of the immune system owing to its vital role in immune surveillance and barrier defense against external pathogens. Here, we present a protocol for isolating and analyzing im
Externí odkaz:
https://doaj.org/article/c6a304713f7b473eb57fc621e0b72e39
Natural antibodies are required for clearance of necrotic cells and recovery from acute liver injury
Autor:
Matheus Silvério Mattos, Sofie Vandendriessche, Sara Schuermans, Lars Feyaerts, Nadine Hövelmeyer, Ari Waisman, Pedro Elias Marques
Publikováno v:
JHEP Reports, Vol 6, Iss 4, Pp 101013- (2024)
Background & Aims: Hepatocellular necrosis is common in both acute and chronic liver injury and may evolve to fibrosis and liver failure. Injury leads to accumulation of necrotic cell debris in the liver, which drives persistent inflammation and poor
Externí odkaz:
https://doaj.org/article/3681b72ea6c4469fba06d59638e27087
Autor:
Berenice Fischer, Tanja Kübelbeck, Antonia Kolb, Julia Ringen, Ari Waisman, Miriam Wittmann, Susanne Karbach, Stephan Marcus Kölsch, Daniela Kramer
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Plaque psoriasis is an autoinflammatory and autoimmune skin disease, affecting 1-3% of the population worldwide. Previously, high levels of IL-36 family cytokines were found in psoriatic skin lesions, thereby contributing to keratinocyte hyperprolife
Externí odkaz:
https://doaj.org/article/c09af3e842354597b44bb3049b851775
Autor:
Jefferson Antônio Leite, Luísa Menezes, Eloisa Martins, Tamara Silva Rodrigues, Lucas Tavares, Anna Ebering, Carsten Schelmbauer, Guilherme C. Martelossi Cebinelli, Valeriya Zinina, Artemiy Golden, Natalia Soshnikova, Dario S. Zamboni, Fernando Q. Cunha, Magdalena Huber, João Santana Silva, Ari Waisman, Daniela Carlos, Niels Olsen Saraiva Câmara
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108134- (2023)
Summary: AIM2 is an interferon-inducible HIN-200 protein family member and is well-documented for its roles in innate immune responses as a DNA sensor. Recent studies have highlighted AIM2’s function on regulatory T cells (Treg) and follicular T ce
Externí odkaz:
https://doaj.org/article/4aa4b8055f9049c997033944049dce04
Autor:
Zhongding Li, Baohua Liu, Kate Lykke Lambertsen, Bettina Hjelm Clausen, Zhenhu Zhu, Xue Du, Yanqi Xu, Frantz Rom Poulsen, Bo Halle, Christian Bonde, Meng Chen, Xue Wang, Dirk Schlüter, Jingyong Huang, Ari Waisman, Weihong Song, Xu Wang
Publikováno v:
Advanced Science, Vol 10, Iss 28, Pp n/a-n/a (2023)
Abstract Cerebral ischemic stroke is a leading cause of morbidity and mortality globally. However, the mechanisms underlying ischemic stroke injury remain poorly understood. Here, it is found that deficiency of the ubiquitin‐specific protease USP25
Externí odkaz:
https://doaj.org/article/4949d5f837264796a353fe045437bd86
Autor:
Nadine Gehrke, Marcus A. Wörns, Amrit Mann, Nadine Hövelmeyer, Ari Waisman, Beate K. Straub, Peter R. Galle, Jörn M. Schattenberg
Publikováno v:
Cell Death and Disease, Vol 13, Iss 5, Pp 1-12 (2022)
Abstract Acute liver failure (ALF) is a rare entity but exhibits a high mortality. The mechanisms underlying ALF are not completely understood. The present study explored the role of the hepatic B cell leukemia-3 (Bcl-3), a transcriptional regulator
Externí odkaz:
https://doaj.org/article/a7c9f6bc2f78494daefe0132b228da87
Autor:
Tanja Klaus, Alicia S. Wilson, Elisabeth Vicari, Eva Hadaschik, Matthias Klein, Sara Salome Clara Helbich, Nadine Kamenjarin, Katrin Hodapp, Jenny Schunke, Maximilian Haist, Florian Butsch, Hans Christian Probst, Alexander H. Enk, Karsten Mahnke, Ari Waisman, Monika Bednarczyk, Matthias Bros, Tobias Bopp, Stephan Grabbe
Publikováno v:
JCI Insight, Vol 7, Iss 24 (2022)
Leukocyte adhesion deficiency type 1 (LAD-1) is a rare disease resulting from mutations in the gene encoding for the common β-chain of the β2-integrin family (CD18). The most prominent clinical symptoms are profound leukocytosis and high susceptibi
Externí odkaz:
https://doaj.org/article/e28c3e696f2746a1a0b61970c4320b2c
Autor:
Anna Juliane Vesting, Alexander Jais, Paul Klemm, Lukas Steuernagel, Peter Wienand, Morten Fog-Tonnesen, Henning Hvid, Anna–Lena Schumacher, Christian Kukat, Hendrik Nolte, Theodoros Georgomanolis, Janine Altmüller, Manolis Pasparakis, Andreas Schmidt, Marcus Krüger, Marc Schmidt Supprian, Ari Waisman, Beate Katharina Straub, Nathanael Raschzok, Michel Bernier, Andreas L. Birkenfeld, Nadine Hövelmeyer, Jens C. Brüning, F. Thomas Wunderlich
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101626- (2022)
Objective: Nonalcoholic fatty liver disease (NAFLD) ranges from steatosis to nonalcoholic steatohepatitis (NASH), which often progresses to hepatocellular carcinoma (HCC) through a largely undefined mechanism. NASH and HCC depend on inflammatory sign
Externí odkaz:
https://doaj.org/article/2bae8d5e2cd240e7ae3c80f88b871897
Autor:
Nadine Gehrke, Lea J. Hofmann, Beate K. Straub, Frank Rühle, Ari Waisman, Peter R. Galle, Jörn M. Schattenberg
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 9, Pp n/a-n/a (2022)
Abstract Background Nonalcoholic fatty liver disease (NAFLD) is associated with hepatic as well as systemic insulin resistance even in the absence of type 2 diabetes. The extent and pathways through which hepatic inflammation modulates insulin sensit
Externí odkaz:
https://doaj.org/article/f148ac8f3cbd42df84f68542741c90ac