Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Ari Tolonen"'
Autor:
Tuire Salonurmi, Heba Nabil, Justiina Ronkainen, Tuulia Hyötyläinen, Heidi Hautajärvi, Markku J. Savolainen, Ari Tolonen, Matej Orešič, Päivi Känsäkoski, Jaana Rysä, Jukka Hakkola, Janne Hukkanen
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Activation of pregnane X receptor (PXR) elevates circulating 4β-hydroxycholesterol (4βHC), an agonist of liver X receptor (LXR). PXR may also regulate 25-hydroxycholesterol and 27-hydroxycholesterol. Our aim was to elucidate the roles of PXR and ox
Externí odkaz:
https://doaj.org/article/fb0247ae26fc400a98ce2a9c876ed0e1
Publikováno v:
Frontiers in Pharmacology, Vol 1 (2010)
Liquid chromatography-mass spectrometry (LC/MS) with generic gradient elution for a large number of chemically different compounds is a common approach in drug development, used to acquire a large amount of data in a short time frame for drug candida
Externí odkaz:
https://doaj.org/article/5d7b104c8e164552bc435f534e53ff33
Autor:
Anam Hammid, John K. Fallon, Toni Lassila, Paula Vieiro, Anusha Balla, Francisco Gonzalez, Arto Urtti, Philip C. Smith, Ari Tolonen, Paavo Honkakoski
Publikováno v:
Drug Metabolism and Disposition. 50:1483-1492
As a multitissue organ, the eye possesses unique anatomy and physiology, including differential expression of drug-metabolizing enzymes. Several hydrolytic enzymes that play a major role in drug metabolism and bioactivation of prodrugs have been dete
Autor:
Achim Sauer, John K. Fallon, Arto Urtti, Anam Hammid, Giulia Salluce, Paavo Honkakoski, Philip C. Smith, Ari Tolonen, Toni Lassila
Publikováno v:
Molecular Pharmaceutics
Mol Pharm
Mol Pharm
Hydrolytic reactions constitute an important pathway of drug metabolism and a significant route of prodrug activation. Many ophthalmic drugs and prodrugs contain ester groups that greatly enhance their permeation across several hydrophobic barriers i
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 225:115219
Autor:
Juho Hokkanen, Olayemi M. Adegbolagun, Titilayo O. Fakeye, Ari Tolonen, Sharon I. Igbinoba, Marena Kajula, Johnson Segun Showande
Publikováno v:
Journal of Basic and Clinical Physiology and Pharmacology. 30
Background Hibiscus sabdariffa beverage (HSB) is widely consumed as a medicinal herb and sometimes used concomitantly with drugs. This study evaluated the in vitro inhibitory potential of the aqueous extract of H. sabdariffa calyces (AEHS) on selecte
Autor:
Juha Jyrkäs, Ari Tolonen
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 196:113921
The number of approved peptide therapeutics has increased significantly in recent years. Peptide therapeutics have many advances over small molecule drugs, such as higher affinity to target and lower toxicity profiles. Although peptide-like drugs are
Autor:
Hans-Georg Sahl, Pere Picart, Ari Turpeinen, Marena Kajula, Janne A. Ihalainen, Mysore V. Tejesvi, Anna Maria Pirttilä, Sampo Mattila, Ari Tolonen, Juho Hokkanen, Joshua M. Ward, Heikki Häkkänen
Publikováno v:
Journal of Natural Products. 79:685-690
Three new epithiodiketopiperazine natural products [outovirin A (1), outovirin B (2), and outovirin C (3)] resembling the antifungal natural product gliovirin have been identified in extracts of Penicillium raciborskii, an endophytic fungus isolated
Publikováno v:
Rapid Communications in Mass Spectrometry. 30:917-926
RATIONALE Menthofuran is a hepatotoxin and a major metabolite of pulegone, a monoterpene found in the essential oils of many mint species. It is bioactivated by cytochrome P450 (CYP) enzymes to reactive metabolites, which may further react with gluta
Autor:
Jenni Küblbeck, Paavo Honkakoski, Kati-Sisko Vellonen, Ari Tolonen, Jenni J. Hakkarainen, Markus M. Forsberg, Aleksanteri Petsalo, Petri Reponen
Publikováno v:
Journal of Pharmaceutical Sciences. 105:941-949
The human intestinal Caco-2 cell line has been extensively used as a model of small intestinal absorption but it lacks expression and function of cytochrome P450 enzymes, particularly CYP3A4 and CYP2C9, which are normally expressed in the intestinal