Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ari Sudwarts"'
Autor:
Ari Sudwarts, Gopal Thinakaran
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-21 (2023)
Abstract Despite expressing many key risk genes, the role of microglia in late-onset Alzheimer’s disease pathophysiology is somewhat ambiguous, with various phenotypes reported to be either harmful or protective. Herein, we review some key findings
Externí odkaz:
https://doaj.org/article/55873b591a54464ead4d69e8929e4fee
Autor:
Ari Sudwarts, Supriya Ramesha, Tianwen Gao, Moorthi Ponnusamy, Shuai Wang, Mitchell Hansen, Alena Kozlova, Sara Bitarafan, Prateek Kumar, David Beaulieu-Abdelahad, Xiaolin Zhang, Lisa Collier, Charles Szekeres, Levi B. Wood, Jubao Duan, Gopal Thinakaran, Srikant Rangaraju
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-27 (2022)
Abstract Background The BIN1 locus contains the second-most significant genetic risk factor for late-onset Alzheimer’s disease. BIN1 undergoes alternate splicing to generate tissue- and cell-type-specific BIN1 isoforms, which regulate membrane dyna
Externí odkaz:
https://doaj.org/article/5b885f3d291245d3b19ec792e0b820ed
Autor:
Pierre De Rossi, Toshihiro Nomura, Robert J. Andrew, Nicolas Y. Masse, Vandana Sampathkumar, Timothy F. Musial, Ari Sudwarts, Aleksandra J. Recupero, Thomas Le Metayer, Mitchell T. Hansen, Ha-Na Shim, Sofia V. Krause, David J. Freedman, Vytas P. Bindokas, Narayanan Kasthuri, Daniel A. Nicholson, Anis Contractor, Gopal Thinakaran
Publikováno v:
Cell Reports, Vol 30, Iss 10, Pp 3520-3535.e7 (2020)
Summary: BIN1, a member of the BAR adaptor protein family, is a significant late-onset Alzheimer disease risk factor. Here, we investigate BIN1 function in the brain using conditional knockout (cKO) models. Loss of neuronal Bin1 expression results in
Externí odkaz:
https://doaj.org/article/3ee20aa26dbb4398a318c588047a8aa8
Autor:
Judit García-González, Alistair J Brock, Matthew O Parker, Riva J Riley, David Joliffe, Ari Sudwarts, Muy-Teck Teh, Elisabeth M Busch-Nentwich, Derek L Stemple, Adrian R Martineau, Jaakko Kaprio, Teemu Palviainen, Valerie Kuan, Robert T Walton, Caroline H Brennan
Publikováno v:
eLife, Vol 9 (2020)
To facilitate smoking genetics research we determined whether a screen of mutagenized zebrafish for nicotine preference could predict loci affecting smoking behaviour. From 30 screened F3 sibling groups, where each was derived from an individual ethy
Externí odkaz:
https://doaj.org/article/5047a4e5ac344a06a8f71324faeda877
Autor:
Maria Elena Miletto Petrazzini, Caroline H. Brennan, David Pritchett, Alistair J. Gibbon, Barbara D. Fontana, Matthew O. Parker, Madeleine Cleal, Ari Sudwarts
Publikováno v:
Fontana, B D, Gibbon, A J, Cleal, M, Sudwarts, A, Pritchett, D, Miletto Petrazzini, M E, Brennan, C H & Parker, M O 2020, ' Moderate early life stress improves adult zebrafish ( Danio rerio ) working memory but does not affect social and anxiety-like responses ', Developmental Psychobiology . https://doi.org/10.1002/dev.21986
Early life stress (ELS) is defined as a short or chronic period of trauma, environmental or social deprivation, which can affect different neurochemical and behavioral patterns during adulthood. Zebrafish (Danio rerio ) have been widely used as a mod
Autor:
Elisabeth M. Busch-Nentwich, Judit García-González, Matthew O. Parker, Adrian R. Martineau, Riva J Riley, Teemu Palviainen, Muy-Teck Teh, Ari Sudwarts, Caroline H. Brennan, Valerie Kuan, David A. Jolliffe, Jaakko Kaprio, Robert Walton, Alistair J. Brock, Derek L. Stemple
Publikováno v:
eLife, Vol 9 (2020)
eLife
García-González, J, Brock, A J, Parker, M O, Riley, R J, Joliffe, D, Sudwarts, A, Teh, M-T, Busch-Nentwich, E M, Stemple, D L, Martineau, A R, Kaprio, J, Palviainen, T, Kuan, V, Walton, R T & Brennan, C H 2020, ' Identification of slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour ', eLife, vol. 9, e51295 . https://doi.org/10.7554/eLife.51295
eLife
García-González, J, Brock, A J, Parker, M O, Riley, R J, Joliffe, D, Sudwarts, A, Teh, M-T, Busch-Nentwich, E M, Stemple, D L, Martineau, A R, Kaprio, J, Palviainen, T, Kuan, V, Walton, R T & Brennan, C H 2020, ' Identification of slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour ', eLife, vol. 9, e51295 . https://doi.org/10.7554/eLife.51295
BACKGROUND: Although there is clear evidence of genetic contributions to susceptibility to nicotine addiction, it has proved difficult to identify causal alleles and pathways from studies in humans. Mutagenesis in model species generates strong pheno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25cb072038ea3141f00ba584d6964652
https://www.repository.cam.ac.uk/handle/1810/305529
https://www.repository.cam.ac.uk/handle/1810/305529
Autor:
David Joliffe, Alistair J. Brock, Elisabeth M. Busch-Nentwich, Adrian R. Martineau, Valerie Kuan, Matthew O. Parker, Teemu Palviainen, Muy-Teck Teh, Caroline H. Brennan, Jaakko Kaprio, Robert Walton, Ari Sudwarts, Riva J Riley, Judit García-González, Derek L. Stemple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f18be9238fb000712e54bb89e2c93e2d
https://doi.org/10.7554/elife.51295.sa2
https://doi.org/10.7554/elife.51295.sa2
Autor:
Narayanan Kasthuri, Robert J. Andrew, Thomas Le Metayer, Vytas P. Bindokas, Ha Na Shim, Gopal Thinakaran, Sofia V. Krause, David J. Freedman, Mitchell T. Hansen, Vandana Sampathkumar, Daniel A. Nicholson, Ari Sudwarts, Anis Contractor, Nicolas Y. Masse, Timothy F. Musial, Toshihiro Nomura, Pierre De Rossi, Aleksandra J. Recupero
Publikováno v:
Cell reports
Cell Reports, Vol 30, Iss 10, Pp 3520-3535.e7 (2020)
Cell Reports, Vol 30, Iss 10, Pp 3520-3535.e7 (2020)
SUMMARY BIN1, a member of the BAR adaptor protein family, is a significant late-onset Alzheimer disease risk factor. Here, we investigate BIN1 function in the brain using conditional knockout (cKO) models. Loss of neuronal Bin1 expression results in
Autor:
Toshihiro Nomura, Sofia V. Krause, Vytas P. Bindokas, Mitchell T. Hansen, Narayanan Kasthuri, Vandana Sampathkumar, Nicolase Y. Masse, Robert J. Andrew, Pierre De Rossi, Timothy F. Musial, Anis Contractor, David J. Freedman, Ha-Na Shim, Aleksandra J. Recupero, Daniel A. Nicholson, Ari Sudwarts, Gopal Thinakaran, Thomas Le Metayer
Publikováno v:
SSRN Electronic Journal.
BIN1, a member of the BAR adaptor protein family, is a significant late-onset Alzheimer’s disease risk factor. Here, we investigated BIN1 function in the brain using conditional knockout (cKO) models. The loss of neuronal Bin1 expression resulted i
Autor:
Andrew N. Mead, Ari Sudwarts, Susan M.G. Goody, Alistair J. Brock, Matthew O. Parker, Caroline H. Brennan
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 363(1)
Regulatory agencies recommend that centrally active drugs are tested for abuse potential before approval. Standard preclinical assessments are conducted in rats or non-human primates (NHPs). This study evaluated the ability of the zebrafish condition