Novel N,N-di-alkylnaphthoimidazolium derivative of β-lapachone impaired Trypanosoma cruzi mitochondrial electron transport system

Autor: Ana Cristina S. Bombaça, Leonardo A. Silva, Otávio Augusto Chaves, Lorrainy S. da Silva, Juliana M.C. Barbosa, Ari M. da Silva, Aurélio B.B. Ferreira, Rubem F.S. Menna-Barreto

Publikováno v: Biomedicine & Pharmacotherapy, Vol 135, Iss , Pp 111186- (2021)

Trypanosoma cruzi is a protozoan parasite that causes Chagas disease, a neglected tropical disease that is endemic in Latin America and spreading worldwide due to globalization. The current treatments are based on benznidazole and nifurtimox; however

Externí odkaz: https://doaj.org/article/ddbceab790d64343b85195e85a9334b9

New Pair of 2-Amino-naphthoxazoles Derived from β-Lapachone: Synthesis, Spectral Evaluation and Crystal Structure

Autor: Leonardo Davi Silveira Augusto Baptista da Silva, Guilherme P. Guedes, Ari M. da Silva, Emanoel Hottes, Aurélio B. B. Ferreira, Luan M. S. Freire

Publikováno v: Journal of the Brazilian Chemical Society v.32 n.5 2021
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ

This work describes a novel synthetic route for obtaining 2-amino-naphthoxazoles derived from β-lapachone, which consists of a condensation reaction between β-lapachone and thiourea in a basic medium. This synthetic approach can be seen as a potent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b9699d34075010e4a427e6c47c5ee54
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532021000501009

Ingasaponin, a complex triterpenoid saponin with immunological adjuvant activity from Inga laurina

Autor: Bernadete Pereira da Silva, José Paz Parente, Gabriela Moysés Pereira, Marcela Gonçalves Ribeiro, Ari M. da Silva, Maria de Fátima Simão Jucá Cruz, Luzineide W. Tinoco

Publikováno v: Carbohydrate research. 420

As part of our search of bioactive saponins from Brazilian plants, phytochemical study of the seeds of Inga laurina led to the isolation of a new complex triterpenoid saponin, named ingasaponin. It is the first saponin isolated from a species of Inga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1728b69ecf1ad011c9e23ea47680e8ca
https://pubmed.ncbi.nlm.nih.gov/26717546

Crystal Structure and Hydrogen Bonding Study of (10E)-2,2-Dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione 10-Oxime Derived From a-Lapachone

Autor: Ari M. da Silva, Aurélio B. B. Ferreira, Marcelo H. Herbst, Andrea Rosane da Silva, Lorenzo C. Visentin

Publikováno v: Molecules
Volume 16
Issue 2
Pages 1192-1200
Molecules, Vol 16, Iss 2, Pp 1192-1200 (2011)

The compound (10E)-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione-10-oxime (1) was synthesized from a-lapachone and hydroxylamine chloride in alkaline medium. Single-crystals suitable for X-ray diffraction measurements were grown from an eth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcb36b9e3d9736c7ba4c672f5ad5dea7