Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Ari Koivisto"'
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 12, p 6629 (2022)
Netrin-1, a chemoattractant expressed by floor plate cells, and one of its receptors (deleted in colorectal cancer) has been associated with pronociceptive actions in a number of pain conditions. Here, we addressed the question of whether spinal TRPC
Externí odkaz:
https://doaj.org/article/3f4572825aa0492cb47301728b51f64f
Publikováno v:
Pharmaceuticals, Vol 11, Iss 4, p 117 (2018)
Here, we review the literature assessing the role of transient receptor potential ankyrin 1 (TRPA1), a calcium-permeable non-selective cation channel, in various types of pain conditions. In the nervous system, TRPA1 is expressed in a subpopulation o
Externí odkaz:
https://doaj.org/article/4b1b276dc2c3414c9b5ae3fa41370756
Publikováno v:
Pharmacological Reports. 71:54-60
Background: The central amygdaloid nucleus (CeA) is involved in processing and descending regulation of pain. Amygdaloid mechanisms underlying pain processing and control are poorly known. Here we tested the hypothesis that perioperative CeA administ
Autor:
Ari Koivisto, Antti Pertovaara
Publikováno v:
University of Helsinki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::95f9a9573681cfa8af3297267f865322
http://hdl.handle.net/10138/351864
http://hdl.handle.net/10138/351864
Publikováno v:
European journal of pharmacology. 882
Fadolmidine is an α2-adrenoceptor full agonist developed for spinal analgesia with a local mode of action. The purpose of this study was to demonstrate the safety of fadolmidine on known α2-adrenoceptor-related effects: kidney function, urodynamics
Publikováno v:
Pharmaceuticals, Vol 11, Iss 4, p 117 (2018)
Pharmaceuticals
Pharmaceuticals
Here, we review the literature assessing the role of transient receptor potential ankyrin 1 (TRPA1), a calcium-permeable non-selective cation channel, in various types of pain conditions. In the nervous system, TRPA1 is expressed in a subpopulation o
Autor:
Jelena Mijatovic, Petteri Piepponen, Katja Kuokkanen, Heikki Tanila, Johanna Holappa, Jukka Sallinen, Raimo Virtanen, Jouni Sirviö, Hugh Chapman, Antti Haapalinna, Ari Koivisto, Jyrki Lehtimäki
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 113:239-249
The α2-adrenoceptors (ARs) are important modulators of a wide array of physiological responses. As only a few selective compounds for the three α2-AR subtypes (α2A , α2B and α2C ) have been available, the pharmacological profile of a new α2C-se
Autor:
Hanna Viisanen, Hugh Chapman, Hong Wei, Maria Lasierra Losada, Ari Koivisto, Karl Åkerman, Antti Pertovaara
Publikováno v:
Scopus-Elsevier
Europe PubMed Central
CIÊNCIAVITAE
University of Helsinki
Europe PubMed Central
CIÊNCIAVITAE
University of Helsinki
Methylglyoxal (MG) is a reactive carbonyl compound generated in diabetes mellitus. MG is an established transient receptor potential ankyrin 1 (TRPA1) channel agonist that contributes to TRPA1-mediated diabetic pain hypersensitivity. Here we studied
Autor:
Antti Pertovaara, Ari Koivisto
Publikováno v:
European Journal of Pharmacology. 666:1-4
Transient receptor potential ankyrin 1 (TRPA1) is a non-selective, calcium permeable cation channel expressed by a subpopulation of primary afferent nociceptive nerve fibers. On peripheral nerve endings, TRPA1 channel contributes to transduction of c
Autor:
Ari Koivisto, Raimo Virtanen, Tiina Leino, Tarja Lehtimäki, Katja Kuokkanen, Antti Haapalinna, Jyrki Lehtimäki, Timo Viitamaa
Publikováno v:
European Journal of Pharmacology. 599:65-71
Alpha2-adrenergic receptors (alpha2-adrenoceptors) mediate various physiological actions of endogenous catecholamines in the central and peripheral nervous systems being involved in alertness, heart rate regulation, vasomotor control and nociceptive