Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Ari J. Firestone"'
Autor:
Rita Sulahian, Jason J. Kwon, Katherine H. Walsh, Emma Pailler, Timothy L. Bosse, Maneesha Thaker, Diego Almanza, Joshua M. Dempster, Joshua Pan, Federica Piccioni, Nancy Dumont, Alfredo Gonzalez, Jonathan Rennhack, Behnam Nabet, John A. Bachman, Amy Goodale, Yenarae Lee, Mukta Bagul, Rosy Liao, Adrija Navarro, Tina L. Yuan, Raymond W.S. Ng, Srivatsan Raghavan, Nathanael S. Gray, Aviad Tsherniak, Francisca Vazquez, David E. Root, Ari J. Firestone, Jeff Settleman, William C. Hahn, Andrew J. Aguirre
Publikováno v:
Cell Reports, Vol 29, Iss 1, Pp 118-134.e8 (2019)
Summary: The mitogen-activated protein kinase (MAPK) pathway is a critical effector of oncogenic RAS signaling, and MAPK pathway inhibition may be an effective combination treatment strategy. We performed genome-scale loss-of-function CRISPR-Cas9 scr
Externí odkaz:
https://doaj.org/article/9a62a78ea0ee4966a7135dceb3c889af
Autor:
Yasmine White, Aditi Bagchi, Jessica Van Ziffle, Anagha Inguva, Gideon Bollag, Chao Zhang, Heidi Carias, David Dickens, Mignon Loh, Kevin Shannon, Ari J. Firestone
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Amino acid substitutions in K-Ras that constitutively activate the protein are common in cancer. Here, the authors describe mutations in the K-RasSwitch 2 domain and show that the mutant proteins accumulate in the active conformation, exhibit defecti
Externí odkaz:
https://doaj.org/article/c8ee34111da64f238c6f182195674d48
Autor:
John T. Randolph, Matthew J. O’Connor, Fei Han, Charles W. Hutchins, Y. Amy Siu, Min Cho, Yunan Zheng, Jonathan A. Hickson, Jana L. Markley, Vlasios Manaves, Mikkel Algire, Kenton A. Baker, Alex M. Chapman, Sujatha M. Gopalakrishnan, Sanjay C. Panchal, Kelly Foster-Duke, DeAnne F. Stolarik, Anita Kempf-Grote, Darby Dammeier, Stacey Fossey, Qi Sun, Chaohong Sun, Yu Shen, Michael J. Dart, Warren M. Kati, Albert Lai, Ari J. Firestone, Michael E. Kort
Publikováno v:
Journal of Medicinal Chemistry. 66:3852-3865
Autor:
Kevin Shannon, Michelle M. Le Beau, Tyler Jacks, James Downing, Joy Nakitandwe, Shann-Ching Chen, Elizabeth Davis, Qing Li, Megan E. McNerney, Ari J. Firestone, Kevin M. Haigis, Jin Xu
Supplementary Figure 5 - PDF file 30K, Figure showing RAS expression in hematopoietic cancer cell lines and human pediatric AML samples
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75601aae90293dcf181a90cf440bbbeb
https://doi.org/10.1158/2159-8290.22530903
https://doi.org/10.1158/2159-8290.22530903
Autor:
Kevin Shannon, Michelle M. Le Beau, Tyler Jacks, James Downing, Joy Nakitandwe, Shann-Ching Chen, Elizabeth Davis, Qing Li, Megan E. McNerney, Ari J. Firestone, Kevin M. Haigis, Jin Xu
Supplementary Figure 4 - PDF file 64K, Data showing the molecular Analysis of AMLs from NrasG12D/+ Mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ca7a3e352d06b474e0141167d5c755
https://doi.org/10.1158/2159-8290.22530906
https://doi.org/10.1158/2159-8290.22530906
Autor:
Kevin Shannon, Michelle M. Le Beau, Tyler Jacks, James Downing, Joy Nakitandwe, Shann-Ching Chen, Elizabeth Davis, Qing Li, Megan E. McNerney, Ari J. Firestone, Kevin M. Haigis, Jin Xu
Supplementary Figure 2 - PDF file 177K, Data showing survival and Hematologic Parameters of Nras heterozygous, hemizygous and homozygous mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::036ff5b6980c62b1476f1d7c141eda74
https://doi.org/10.1158/2159-8290.22530900
https://doi.org/10.1158/2159-8290.22530900
Autor:
Kevin Shannon, Michelle M. Le Beau, Tyler Jacks, James Downing, Joy Nakitandwe, Shann-Ching Chen, Elizabeth Davis, Qing Li, Megan E. McNerney, Ari J. Firestone, Kevin M. Haigis, Jin Xu
Supplementary Figure 1 - PDF file 150K, Figure showing the generation and Functional Validation of a Conditional Mutant Nrasflox Allele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6092e5a3f902fa3be965e74a4a9fb2b7
https://doi.org/10.1158/2159-8290.22530912.v1
https://doi.org/10.1158/2159-8290.22530912.v1
Autor:
Amanda Long, Anagha Inguva, Marina Predovic, Jarrett R. Remsberg, Thomas W. Hanigan, Stewart K. Richardson, Noemi A. Zambetti, Micah J. Niphakis, Nhi Ngo, Amy R. Howell, Cassandra L. Henry, Ari J. Firestone, Benjamin F. Cravatt, Kenneth M. Lum, Ben Huang, Kevin Shannon, Radu M. Suciu, Melissa M. Dix
Publikováno v:
Nature chemical biology, vol 17, iss 8
Multiple Ras proteins, including N-Ras, depend on a palmitoylation/depalmitoylation cycle to regulate their subcellular trafficking and oncogenicity. General lipase inhibitors such as Palmostatin M (Palm M) block N-Ras depalmitoylation, but lack spec
Autor:
Rosy Liao, Joshua Pan, Raymond W.S. Ng, Federica Piccioni, Jonathan P. Rennhack, Ari J. Firestone, William C. Hahn, Amy Goodale, Diego Almanza, Andrew J. Aguirre, John A. Bachman, Emma Pailler, David E. Root, Srivatsan Raghavan, Tina L. Yuan, Mukta Bagul, Nathanael S. Gray, Alfredo Gonzalez, Yenarae Lee, Jason J. Kwon, Katherine H. Walsh, Nancy Dumont, Timothy L. Bosse, Behnam Nabet, Francisca Vazquez, Jeff Settleman, Aviad Tsherniak, Joshua M. Dempster, Adrija J. Navarro, Maneesha Thaker, Rita Sulahian
Publikováno v:
Cell Reports, Vol 29, Iss 1, Pp 118-134.e8 (2019)
Summary: The mitogen-activated protein kinase (MAPK) pathway is a critical effector of oncogenic RAS signaling, and MAPK pathway inhibition may be an effective combination treatment strategy. We performed genome-scale loss-of-function CRISPR-Cas9 scr
Autor:
Chulangani Weerasooriya, Radu M. Suciu, Benjamin F. Cravatt, Irungu K. Luvaga, Amy R. Howell, Ari J. Firestone, Kevin Shannon, Akram Hazeen, Stewart K. Richardson
Publikováno v:
Bioorg Med Chem Lett
S-Palmitoylation is a reversible post-translational lipid modification that regulates protein trafficking and signaling. The enzymatic depalmitoylation of proteins is inhibited by the beta-lactones Palmostatin M and B, which have been found to target