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Akademický článek

Sorting Nexin 10 as a Key Regulator of Membrane Trafficking in Bone-Resorbing Osteoclasts: Lessons Learned From Osteopetrosis

Autor: Ari Elson, Merle Stein, Grace Rabie, Maayan Barnea-Zohar, Sabina Winograd-Katz, Nina Reuven, Moran Shalev, Juraj Sekeres, Moien Kanaan, Jan Tuckermann, Benjamin Geiger

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Bone homeostasis is a complex, multi-step process, which is based primarily on a tightly orchestrated interplay between bone formation and bone resorption that is executed by osteoblasts and osteoclasts (OCLs), respectively. The essential physiologic

Externí odkaz: https://doaj.org/article/9140739a9d7b48219d5b2ec60c0dbfdf

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Akademický článek

Role of OSCAR Signaling in Osteoclastogenesis and Bone Disease

Autor: Iva R. Nedeva, Mattia Vitale, Ari Elson, Judith A. Hoyland, Jordi Bella

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Formation of mature bone-resorbing cells through osteoclastogenesis is required for the continuous remodeling and repair of bone tissue. In aging and disease this process may become aberrant, resulting in excessive bone degradation and fragility frac

Externí odkaz: https://doaj.org/article/e5e32e1900564de7a6e6c19da3575d4e

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PTPRJ promotes osteoclast maturation and activity by inhibiting Cbl‐mediated ubiquitination of NFATc1 in late osteoclastogenesis

Autor: Moran Shalev, Sergey Kapishnikov, Esther Arman, Merle Stein, Isabelle Royal, Vlad Brumfeld, Ari Elson, Jan Tuckermann, Yael Cohen-Sharir

Publikováno v: The FEBS Journal. 288:4702-4723

Bone-resorbing osteoclasts (OCLs) are multinucleated phagocytes, whose central roles in regulating bone formation and homeostasis are critical for normal health and development. OCLs are produced from precursor monocytes in a multistage process that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27be8d3508c10d7c35e4fed2edb35696
https://doi.org/10.1111/febs.15778

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The roles of protein tyrosine phosphatases in bone-resorbing osteoclasts

Autor: Ari Elson, Moran Shalev

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1866:114-123

Maintaining the proper balance between osteoblast-mediated production of bone and its degradation by osteoclasts is essential for health. Osteoclasts are giant phagocytic cells that are formed by fusion of monocyte-macrophage precursor cells; mature

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d64350bf504ee032fa9a3c1902e40db4
https://doi.org/10.1016/j.bbamcr.2018.07.005

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An SNX10-dependent mechanism downregulates fusion between mature osteoclasts

Autor: Fadi Thalji, Jan Tuckermann, Merle Stein, Sabina Winograd-Katz, Benjamin Geiger, Esther Arman, Moien Kanaan, Moran Shalev, Ari Elson, Lee Roth, Nina Reuven, Ofra Golani, Maayan Barnea-Zohar

Publikováno v: Journal of Cell Science
article-version (VoR) Version of Record

Homozygosity for the R51Q mutation in sorting nexin 10 (SNX10) inactivates osteoclasts (OCLs) and induces autosomal recessive osteopetrosis in humans and in mice. We show here that the fusion of wild-type murine monocytes to form OCLs is highly regul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f834417c65332f85dc6395b470622136
http://europepmc.org/articles/PMC8182410

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Role of OSCAR Signaling in Osteoclastogenesis and Bone Disease

Autor: Jordi Bella, Judith A. Hoyland, Ari Elson, Mattia Vitale, Iva R. Nedeva

Publikováno v: Frontiers in Cell and Developmental Biology
Nedeva, I, Vitale, M, Elson, A, Hoyland, J & Bella, J 2021, ' Role of OSCAR Signaling in Osteoclastogenesis and Bone Disease ', Front Cell Dev Biol, vol. 9, 641162 . https://doi.org/10.3389/fcell.2021.641162
Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64bd356a1791e82e8c802e37353a4dd7
https://doi.org/10.3389/fcell.2021.641162

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Unravelling the effect of an osteopetrotic Snx10 mutation on bone, muscle and other tissues

Autor: Benjamin Geiger, Polina Stepensky, F Thalji, Maayan Barnea, Merle Stein, Moien Kanaan, Ari Elson, Jan Tuckermann, Hila Elinav, Sabina Winograd-Katz, Esther Arman, Moran Shalev, Ori Brenner

Publikováno v: 1. MuSkITYR Symposium.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::26b305b4c92bf876b3fd5c48e6dfa04a
https://doi.org/10.1055/s-0039-1700643

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Kinetic modeling of DUSP regulation in Herceptin-resistant HER2-positive breast cancer

Autor: Petronela Buiga, Lydia Tabernero, Jean-Marc Schwartz, Ari Elson

Publikováno v: Buiga, P, Elson, A, Tabernero, L & Schwartz, J-M 2019, ' Kinetic modeling of DUSP regulation in Herceptin-resistant HER2-positive breast cancer ', Genes, vol. 10, 568 . https://doi.org/10.3390/genes10080568
Genes, Vol 10, Iss 8, p 568 (2019)
Genes
Volume 10
Issue 8

Background: HER2 (human epidermal growth factor 2)-positive breast cancer is an aggressive type of breast cancer characterized by the overexpression of the receptor-type protein tyrosine kinase HER2 or amplification of the HER2 gene. It is commonly t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfcd6e663e44d1eb356b6799d7a46a8d
https://www.research.manchester.ac.uk/portal/en/publications/kinetic-modeling-of-dusp-regulation-in-herceptinresistant-her2positive-breast-cancer(fd30d440-ebfd-4a5a-87ae-a5d70fbbfabd).html

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Phosphorylation of the phosphatase PTPROt at Tyr

Autor: Lee, Roth, Jean, Wakim, Elad, Wasserman, Moran, Shalev, Esther, Arman, Merle, Stein, Vlad, Brumfeld, Cari A, Sagum, Mark T, Bedford, Jan, Tuckermann, Ari, Elson

Publikováno v: Science signaling. 12(563)

Bone resorption by osteoclasts is essential for bone homeostasis. The kinase Src promotes osteoclast activity and is activated in osteoclasts by the receptor-type tyrosine phosphatase PTPROt. In other contexts, however, PTPROt can inhibit Src activit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::85c27e049573ff79f95bdf78bac72b9e
https://pubmed.ncbi.nlm.nih.gov/30622194

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